Aliases for COMMD7 Gene

Aliases for COMMD7 Gene

  • COMM Domain Containing 7 2 3 5
  • COMM Domain-Containing Protein 7 3 4
  • C20orf92 3 4
  • Chromosome 20 Open Reading Frame 92 2
  • DJ1085F17.3 3

External Ids for COMMD7 Gene

Previous HGNC Symbols for COMMD7 Gene

  • C20orf92

Previous GeneCards Identifiers for COMMD7 Gene

  • GC20M032032
  • GC20M030754
  • GC20M031290
  • GC20M028079

Summaries for COMMD7 Gene

GeneCards Summary for COMMD7 Gene

COMMD7 (COMM Domain Containing 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include NF-kappaB binding. An important paralog of this gene is ENSG00000285382.

UniProtKB/Swiss-Prot Summary for COMMD7 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

Additional gene information for COMMD7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COMMD7 Gene

Genomics for COMMD7 Gene

GeneHancer (GH) Regulatory Elements for COMMD7 Gene

Promoters and enhancers for COMMD7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMMD7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COMMD7

Top Transcription factor binding sites by QIAGEN in the COMMD7 gene promoter:
  • Cart-1
  • FOXD3
  • GATA-1
  • Lmo2
  • MyoD
  • N-Myc
  • Pax-4a

Genomic Locations for COMMD7 Gene

Genomic Locations for COMMD7 Gene
chr20:32,702,691-32,744,008
(GRCh38/hg38)
Size:
41,318 bases
Orientation:
Minus strand
chr20:31,290,493-31,331,814
(GRCh37/hg19)
Size:
41,322 bases
Orientation:
Minus strand

Genomic View for COMMD7 Gene

Genes around COMMD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD7 Gene

Proteins for COMMD7 Gene

  • Protein details for COMMD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VX2-COMD7_HUMAN
    Recommended name:
    COMM domain-containing protein 7
    Protein Accession:
    Q86VX2
    Secondary Accessions:
    • A2BHJ2
    • B3KTZ2
    • Q5JYB0
    • Q96SI7
    • Q9BW53

    Protein attributes for COMMD7 Gene

    Size:
    200 amino acids
    Molecular mass:
    22540 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.

    Alternative splice isoforms for COMMD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMMD7 Gene

Post-translational modifications for COMMD7 Gene

  • Ubiquitination at Lys73
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD7 Gene

Domains & Families for COMMD7 Gene

Gene Families for COMMD7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD7 Gene

Blocks:
  • HCaRG
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD7 Gene

GenScript: Design optimal peptide antigens:
  • COMM domain-containing protein 7 (COMD7_HUMAN)
genes like me logo Genes that share domains with COMMD7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for COMMD7 Gene

Function for COMMD7 Gene

Molecular function for COMMD7 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD7 Gene

Gene Ontology (GO) - Molecular Function for COMMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
GO:0051059 NF-kappaB binding IDA,IBA 15799966
genes like me logo Genes that share ontologies with COMMD7: view
genes like me logo Genes that share phenotypes with COMMD7: view

Animal Model Products

CRISPR Products

miRNA for COMMD7 Gene

miRTarBase miRNAs that target COMMD7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD7 Gene

Localization for COMMD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD7 Gene

Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD7 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COMMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with COMMD7: view

Pathways & Interactions for COMMD7 Gene

PathCards logo

SuperPathways for COMMD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032088 negative regulation of NF-kappaB transcription factor activity IBA,IDA 15799966
GO:0033209 tumor necrosis factor-mediated signaling pathway IBA,IDA 15799966
GO:0045892 negative regulation of transcription, DNA-templated IDA 15799966
genes like me logo Genes that share ontologies with COMMD7: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD7 Gene

Drugs & Compounds for COMMD7 Gene

No Compound Related Data Available

Transcripts for COMMD7 Gene

mRNA/cDNA for COMMD7 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2:
SP3: - -
SP4: -

Relevant External Links for COMMD7 Gene

GeneLoc Exon Structure for
COMMD7

Expression for COMMD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COMMD7 Gene

Protein differential expression in normal tissues from HIPED for COMMD7 Gene

This gene is overexpressed in Bone (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMMD7 Gene



Protein tissue co-expression partners for COMMD7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COMMD7

SOURCE GeneReport for Unigene cluster for COMMD7 Gene:

Hs.408427

mRNA Expression by UniProt/SwissProt for COMMD7 Gene:

Q86VX2-COMD7_HUMAN
Tissue specificity: Widely expressed with highest expression in lung.

Evidence on tissue expression from TISSUES for COMMD7 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Eye(4.1)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with COMMD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD7 Gene

Orthologs for COMMD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMMD7 31 30
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD7 31 30
  • 94.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia COMMD7 31 30
  • 92.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd7 30
  • 88.78 (n)
mouse
(Mus musculus)
Mammalia Commd7 17 31 30
  • 88.61 (n)
oppossum
(Monodelphis domestica)
Mammalia COMMD7 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD7 31 30
  • 74.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD7 31
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii commd7 31 30
  • 61.33 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6641 31
  • 34 (a)
OneToOne
Species where no ortholog for COMMD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD7 Gene

ENSEMBL:
Gene Tree for COMMD7 (if available)
TreeFam:
Gene Tree for COMMD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COMMD7: view image

Paralogs for COMMD7 Gene

Paralogs for COMMD7 Gene

genes like me logo Genes that share paralogs with COMMD7: view

Variants for COMMD7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COMMD7 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
777539 Benign: not provided 32,704,020(-) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for COMMD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for COMMD7 Gene

Variant ID Type Subtype PubMed ID
dgv2240n106 CNV deletion 24896259
esv2552132 CNV deletion 19546169
esv2656560 CNV deletion 23128226
esv2659067 CNV deletion 23128226
esv2665382 CNV deletion 23128226
esv2722345 CNV deletion 23290073
esv3069346 CNV deletion 24192839
esv3557002 CNV deletion 23714750
esv3557003 CNV deletion 23714750
esv3645670 CNV loss 21293372
esv994647 CNV deletion 20482838
nsv1056411 CNV loss 25217958
nsv1061436 CNV gain 25217958
nsv1070389 CNV deletion 25765185
nsv1114212 CNV deletion 24896259
nsv1149719 CNV deletion 26484159
nsv512610 CNV loss 21212237
nsv512611 CNV loss 21212237
nsv833956 CNV loss 17160897
nsv955122 CNV deletion 24416366

Variation tolerance for COMMD7 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD7 Gene

Disorders for COMMD7 Gene

Additional Disease Information for COMMD7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COMMD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD7 Gene

Publications for COMMD7 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 54
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 54
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 54
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for COMMD7 Gene

Sources for COMMD7 Gene