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Aliases for COMMD6 Gene

Aliases for COMMD6 Gene

  • COMM Domain Containing 6 2 3 5
  • Acrg Embryonic Lethality Minimal Region Ortholog 3
  • COMM Domain-Containing Protein 6 3
  • Acrg 3

External Ids for COMMD6 Gene

Previous GeneCards Identifiers for COMMD6 Gene

  • GC13M073897
  • GC13M074998
  • GC13M076099
  • GC13M056796

Summaries for COMMD6 Gene

Entrez Gene Summary for COMMD6 Gene

  • COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

GeneCards Summary for COMMD6 Gene

COMMD6 (COMM Domain Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include NF-kappaB binding.

UniProtKB/Swiss-Prot for COMMD6 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.

Additional gene information for COMMD6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD6 Gene

Genomics for COMMD6 Gene

GeneHancer (GH) Regulatory Elements for COMMD6 Gene

Promoters and enhancers for COMMD6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I075548 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 571.5 -0.4 -433 2.3 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 COMMD6 UCHL3 ENSG00000261553 LMO7-AS1 GC13M075563
GH13I075537 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558 +11.6 11552 1.8 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 COMMD6 UCHL3 LMO7-AS1 GC13M075537 GC13P075531
GH13I075480 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.3 +68.2 68165 4 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 ZNF213 ZNF416 TBC1D4 COMMD6 UCHL3 ENSG00000228444 LMO7-AS1 ENSG00000225203
GH13I075489 Enhancer 1 Ensembl ENCODE 19.4 +59.5 59538 1 HDGF PKNOX1 FOXA2 RAD21 ZNF366 ATF7 IKZF2 RUNX3 EGR2 CEBPB COMMD6 UCHL3 TBC1D4 PIR51840
GH13I075634 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 10.7 -87.0 -87048 3 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 GLIS2 ZNF213 ZNF202 SP3 LMO7-AS1 UCHL3 COMMD6 GC13P075644 LMO7 ENSG00000261553
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COMMD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COMMD6 gene promoter:

Genomic Locations for COMMD6 Gene

Genomic Locations for COMMD6 Gene
24,226 bases
Minus strand

Genomic View for COMMD6 Gene

Genes around COMMD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD6 Gene

Proteins for COMMD6 Gene

  • Protein details for COMMD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A6NF28
    • B7ZLN0
    • Q5TBK4

    Protein attributes for COMMD6 Gene

    85 amino acids
    Molecular mass:
    9638 Da
    Quaternary structure:
    • Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22, CCDC93, SCNN1B, CUL4A.

    Alternative splice isoforms for COMMD6 Gene


neXtProt entry for COMMD6 Gene

Post-translational modifications for COMMD6 Gene

  • Ubiquitination at Lys39
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD6 Gene

Domains & Families for COMMD6 Gene

Gene Families for COMMD6 Gene

Protein Domains for COMMD6 Gene


Suggested Antigen Peptide Sequences for COMMD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD6: view

No data available for UniProtKB/Swiss-Prot for COMMD6 Gene

Function for COMMD6 Gene

Molecular function for COMMD6 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.

Phenotypes From GWAS Catalog for COMMD6 Gene

Gene Ontology (GO) - Molecular Function for COMMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
GO:0051059 NF-kappaB binding IPI 16573520
genes like me logo Genes that share ontologies with COMMD6: view
genes like me logo Genes that share phenotypes with COMMD6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD6 Gene

Localization for COMMD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD6 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD6 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for COMMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COMMD6 Gene

Pathways & Interactions for COMMD6 Gene

SuperPathways for COMMD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 16573520
genes like me logo Genes that share ontologies with COMMD6: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD6 Gene

Drugs & Compounds for COMMD6 Gene

No Compound Related Data Available

Transcripts for COMMD6 Gene

Unigene Clusters for COMMD6 Gene

COMM domain containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4
SP1: - - -
SP4: - -

Relevant External Links for COMMD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD6 Gene

Protein differential expression in normal tissues from HIPED for COMMD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8), Bone marrow stromal cell (10.4), and Breast (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COMMD6 Gene

Protein tissue co-expression partners for COMMD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD6 Gene:


SOURCE GeneReport for Unigene cluster for COMMD6 Gene:


mRNA Expression by UniProt/SwissProt for COMMD6 Gene:

Tissue specificity: Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta.

Evidence on tissue expression from TISSUES for COMMD6 Gene

  • Nervous system(4.5)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with COMMD6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD6 Gene

Orthologs for COMMD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD6 34
  • 98 (a)
(Bos Taurus)
Mammalia COMMD6 34
  • 87 (a)
(Mus musculus)
Mammalia Commd6 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD6 34
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 72 (a)
-- 34
  • 72 (a)
-- 34
  • 70 (a)
(Canis familiaris)
Mammalia COMMD6 34
  • 60 (a)
(Gallus gallus)
Aves COMMD6 34
  • 25 (a)
(Anolis carolinensis)
Reptilia COMMD6 34
  • 23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6964 33
(Danio rerio)
Actinopterygii COMMD6 34
  • 26 (a)
Species where no ortholog for COMMD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD6 Gene

Gene Tree for COMMD6 (if available)
Gene Tree for COMMD6 (if available)

Paralogs for COMMD6 Gene Pseudogenes for COMMD6 Gene

genes like me logo Genes that share paralogs with COMMD6: view

No data available for Paralogs for COMMD6 Gene

Variants for COMMD6 Gene

Sequence variations from dbSNP and Humsavar for COMMD6 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000081218 -- 75,530,615(-) C/G intron_variant
rs1000103111 -- 75,548,287(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000249633 -- 75,530,052(-) C/T intron_variant
rs1000371811 -- 75,536,044(-) C/A/T intron_variant
rs1000536226 -- 75,530,932(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD6 Gene

Variant ID Type Subtype PubMed ID
dgv1048e59 CNV duplication 20981092
dgv1049e59 CNV duplication 20981092
esv23690 CNV gain 19812545
esv2421984 CNV duplication 20811451
esv2596575 CNV gain 19546169
esv2760289 CNV gain 21179565
esv2761803 CNV gain 21179565
esv32759 CNV loss 17666407
esv3326553 CNV duplication 20981092
esv3632749 CNV gain 21293372
nsv1089 CNV insertion 18451855
nsv1090 CNV insertion 18451855
nsv442676 CNV gain 18776908
nsv514711 CNV gain 21397061
nsv521444 CNV gain 19592680
nsv525594 CNV gain 19592680
nsv818980 CNV gain 17921354

Variation tolerance for COMMD6 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD6 Gene

Disorders for COMMD6 Gene

Additional Disease Information for COMMD6

No disorders were found for COMMD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD6 Gene

Publications for COMMD6 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 58
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 58
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 58
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 58
  5. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. (PMID: 16573520) de Bie P … Klomp LW (The Biochemical journal 2006) 3 4 58

Products for COMMD6 Gene

Sources for COMMD6 Gene

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