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COMMD5 Gene(Protein Coding)

COMM Domain Containing 5

GCID:
GC08M144837
GIFtS:
41
Genes Participants
UDN Logo

Aliases for COMMD5 Gene

Aliases for COMMD5 Gene

  • COMM Domain Containing 5 2 3 5
  • Hypertension-Related Calcium-Regulated Gene Protein 3 4
  • HCARG 3 4
  • COMM Domain-Containing Protein 5 3
  • HT002 3

External Ids for COMMD5 Gene

Previous GeneCards Identifiers for COMMD5 Gene

  • GC08M146069
  • GC08M146035
  • GC08M146075
  • GC08M141191
  • GC08M146067

Summaries for COMMD5 Gene

GeneCards Summary for COMMD5 Gene

COMMD5 (COMM Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD5 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Additional gene information for COMMD5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD5 Gene

Genomics for COMMD5 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for COMMD5 Gene

Promoters and enhancers for COMMD5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I144851 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.7 +0.7 708 2.4 CLOCK ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 E2F8 ZNF143 KLF13 COMMD5 ZNF7 RPL8 CPSF1 VPS28 ADCK5 SLC52A2 ZNF16 PARP10 GPAA1
GH08I144899 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 20.2 -47.9 -47855 3.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF250 ZNF7 CPSF1 VPS28 RPL8 ZNF16 ZNF251 SHARPIN GPAA1 PARP10
GH08I144785 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.5 +64.0 64005 9 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC SSRP1 ZNF610 RPL8 ZNF34 PIR52884 VPS28 ZNF7 CPSF1 ZNF250 PARP10 COMMD5 LOC105375803
GH08I144506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.9 +344.8 344767 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MFSD3 ZNF7 CPSF1 VPS28 ZNF250 ZNF623 ZNF251 ENSG00000254533 LRRC14 ZNF707
GH08I144455 Enhancer 1.3 Ensembl ENCODE 29.3 +397.3 397290 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COMMD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COMMD5 gene promoter:

Genomic Locations for COMMD5 Gene

Genomic Locations for COMMD5 Gene
chr8:144,837,978-144,853,736
(GRCh38/hg38)
Size:
15,759 bases
Orientation:
Minus strand
chr8:146,066,427-146,079,121
(GRCh37/hg19)

Genomic View for COMMD5 Gene

Genes around COMMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for COMMD5 Gene

Proteins for COMMD5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for COMMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ3-COMD5_HUMAN
    Recommended name:
    COMM domain-containing protein 5
    Protein Accession:
    Q9GZQ3
    Secondary Accessions:
    • D3DWN7
    • Q9NVN6
    • Q9UHX5

    Protein attributes for COMMD5 Gene

    Size:
    224 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    SequenceCaution:
    • Sequence=AAF14877.1; Type=Frameshift; Positions=66, 84, 112, 136; Evidence={ECO:0000305};

neXtProt entry for COMMD5 Gene

Protein Expression for COMMD5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for COMMD5 Gene

No Post-translational modifications

Other Protein References for COMMD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COMMD5 Gene

Domains & Families for COMMD5 Gene

Gene Families for COMMD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD5: view

No data available for UniProtKB/Swiss-Prot for COMMD5 Gene

Function for COMMD5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for COMMD5 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD5 Gene

Gene Ontology (GO) - Molecular Function for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD5: view

Phenotypes for COMMD5 Gene

GenomeRNAi human phenotypes for COMMD5:
genes like me logo Genes that share phenotypes with COMMD5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD5 Gene

Localization for COMMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with COMMD5: view

Pathways & Interactions for COMMD5 Gene

SuperPathways for COMMD5 Gene

PathCards logo More details on SuperPathways for COMMD5
No Data Available

Gene Ontology (GO) - Biological Process for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD5: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD5 Gene

Drugs & Compounds for COMMD5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for COMMD5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for COMMD5 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(212) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COMMD5 Gene

COMM domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for COMMD5 Gene

GeneLoc Exon Structure for
COMMD5
ECgene alternative splicing isoforms for
COMMD5

Expression for COMMD5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD5 Gene

mRNA expression in normal human tissues for COMMD5 Gene
mRNA expression by GTEx for COMMD5 Gene

Protein differential expression in normal tissues from HIPED for COMMD5 Gene

This gene is overexpressed in Monocytes (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COMMD5 Gene



Protein tissue co-expression partners for COMMD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD5 Gene:

COMMD5

SOURCE GeneReport for Unigene cluster for COMMD5 Gene:

Hs.631856

mRNA Expression by UniProt/SwissProt for COMMD5 Gene:

Q9GZQ3-COMD5_HUMAN
Tissue specificity: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.

Evidence on tissue expression from TISSUES for COMMD5 Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with COMMD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD5 Gene

Orthologs for COMMD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia COMMD5 33 34
  • 98.66 (n)
cow
(Bos Taurus)
 Mammalia COMMD5 33 34
  • 85.57 (n)
dog
(Canis familiaris)
 Mammalia COMMD5 33 34
  • 83.33 (n)
rat
(Rattus norvegicus)
 Mammalia Commd5 33
  • 79.76 (n)
mouse
(Mus musculus)
 Mammalia Commd5 33 16 34
  • 79.46 (n)
chicken
(Gallus gallus)
 Aves COMMD5 33 34
  • 59.76 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia commd5 33
  • 57.55 (n)
Str.138 33
zebrafish
(Danio rerio)
 Actinopterygii commd5 33 34
  • 54.08 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.624 33
Species where no ortholog for COMMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD5 Gene

ENSEMBL:
Gene Tree for COMMD5 (if available)
TreeFam:
Gene Tree for COMMD5 (if available)

Paralogs for COMMD5 Gene

Pseudogenes.org Pseudogenes for COMMD5 Gene

genes like me logo Genes that share paralogs with COMMD5: view

No data available for Paralogs for COMMD5 Gene

Variants for COMMD5 Gene

Sequence variations from dbSNP and Humsavar for COMMD5 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000025187 -- 144,839,454(-) G/A genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000078481 -- 144,839,663(-) G/A genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000119752 -- 144,838,619(-) G/C genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000338509 -- 144,844,275(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000767357 -- 144,847,567(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD5 Gene

Variant ID Type Subtype PubMed ID
nsv1023752 CNV gain 25217958
nsv1031737 CNV gain 25217958
nsv469809 CNV loss 16826518
nsv612969 CNV loss 21841781
nsv6450 CNV insertion 18451855

Variation tolerance for COMMD5 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD5 Gene

Disorders for COMMD5 Gene

Additional Disease Information for COMMD5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COMMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD5 Gene

Publications for COMMD5 Gene

  1. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. (PMID: 10918053) Solban N … Tremblay J (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 58
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 58
  4. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 58
  5. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 58

Products for COMMD5 Gene

Sources for COMMD5 Gene

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