Aliases for COMMD5 Gene

Aliases for COMMD5 Gene

  • COMM Domain Containing 5 2 3 5
  • Hypertension-Related Calcium-Regulated Gene Protein 3 4
  • COMM Domain-Containing Protein 5 3 4
  • HT002 2 3
  • HCaRG 2 4
  • FLJ13008 2
  • COMMD5 5
  • HCARG 3

External Ids for COMMD5 Gene

Previous GeneCards Identifiers for COMMD5 Gene

  • GC08M146069
  • GC08M146035
  • GC08M146075
  • GC08M141191
  • GC08M146067

Summaries for COMMD5 Gene

GeneCards Summary for COMMD5 Gene

COMMD5 (COMM Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for COMMD5 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Additional gene information for COMMD5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COMMD5 Gene

Genomics for COMMD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for COMMD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMMD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COMMD5

Top Transcription factor binding sites by QIAGEN in the COMMD5 gene promoter:
  • AhR
  • AML1a
  • AP-4
  • p300

Genomic Locations for COMMD5 Gene

Genomic Locations for COMMD5 Gene
chr8:144,837,978-144,853,736
(GRCh38/hg38)
Size:
15,759 bases
Orientation:
Minus strand
chr8:146,066,427-146,079,121
(GRCh37/hg19)
Size:
12,695 bases
Orientation:
Minus strand

Genomic View for COMMD5 Gene

Genes around COMMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD5 Gene

Proteins for COMMD5 Gene

  • Protein details for COMMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ3-COMD5_HUMAN
    Recommended name:
    COMM domain-containing protein 5
    Protein Accession:
    Q9GZQ3
    Secondary Accessions:
    • D3DWN7
    • Q9NVN6
    • Q9UHX5

    Protein attributes for COMMD5 Gene

    Size:
    224 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    SequenceCaution:
    • Sequence=AAF14877.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for COMMD5 Gene

Post-translational modifications for COMMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COMMD5 Gene

Domains & Families for COMMD5 Gene

Gene Families for COMMD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD5 Gene

InterPro:
Blocks:
  • HCaRG
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD5 Gene

GenScript: Design optimal peptide antigens:
  • Hypertension-related calcium-regulated gene protein (COMD5_HUMAN)
genes like me logo Genes that share domains with COMMD5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for COMMD5 Gene

Function for COMMD5 Gene

Molecular function for COMMD5 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD5 Gene

Gene Ontology (GO) - Molecular Function for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD5: view
genes like me logo Genes that share phenotypes with COMMD5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD5 Gene

Localization for COMMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with COMMD5: view

Pathways & Interactions for COMMD5 Gene

PathCards logo

SuperPathways for COMMD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COMMD5 Gene

Drugs & Compounds for COMMD5 Gene

No Compound Related Data Available

Transcripts for COMMD5 Gene

mRNA/cDNA for COMMD5 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD5

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for COMMD5 Gene

GeneLoc Exon Structure for
COMMD5

Expression for COMMD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COMMD5 Gene

Protein differential expression in normal tissues from HIPED for COMMD5 Gene

This gene is overexpressed in Monocytes (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMMD5 Gene



Protein tissue co-expression partners for COMMD5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COMMD5

SOURCE GeneReport for Unigene cluster for COMMD5 Gene:

Hs.631856

mRNA Expression by UniProt/SwissProt for COMMD5 Gene:

Q9GZQ3-COMD5_HUMAN
Tissue specificity: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.

Evidence on tissue expression from TISSUES for COMMD5 Gene

  • Nervous system(4.5)
  • Thyroid gland(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with COMMD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD5 Gene

Orthologs for COMMD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia COMMD5 30 31
  • 98.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia COMMD5 30 31
  • 85.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia COMMD5 30 31
  • 83.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Commd5 30
  • 79.76 (n)
Mouse
(Mus musculus)
Mammalia Commd5 30 17 31
  • 79.46 (n)
OneToOne
Chicken
(Gallus gallus)
Aves COMMD5 30 31
  • 59.76 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia commd5 30
  • 57.55 (n)
Str.138 30
Zebrafish
(Danio rerio)
Actinopterygii commd5 30 31
  • 54.08 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.624 30
Species where no ortholog for COMMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for COMMD5 Gene

ENSEMBL:
Gene Tree for COMMD5 (if available)
TreeFam:
Gene Tree for COMMD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COMMD5: view image

Paralogs for COMMD5 Gene

Pseudogenes.org Pseudogenes for COMMD5 Gene

genes like me logo Genes that share paralogs with COMMD5: view

No data available for Paralogs for COMMD5 Gene

Variants for COMMD5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COMMD5 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1209879 - p.Ala6Thr
rs421427 - p.Gln69His

Additional dbSNP identifiers (rs#s) for COMMD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for COMMD5 Gene

Variant ID Type Subtype PubMed ID
nsv1023752 CNV gain 25217958
nsv1031737 CNV gain 25217958
nsv469809 CNV loss 16826518
nsv612969 CNV loss 21841781
nsv6450 CNV insertion 18451855

Variation tolerance for COMMD5 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD5 Gene

Disorders for COMMD5 Gene

Additional Disease Information for COMMD5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for COMMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD5 Gene

Publications for COMMD5 Gene

  1. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. (PMID: 10918053) Solban N … Tremblay J (The Journal of biological chemistry 2000) 2 3 4 23
  2. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4
  4. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4
  5. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4

Products for COMMD5 Gene

Sources for COMMD5 Gene