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Aliases for COMMD4 Gene

Aliases for COMMD4 Gene

  • COMM Domain Containing 4 2 3 5
  • COMM Domain-Containing Protein 4 3

External Ids for COMMD4 Gene

Previous GeneCards Identifiers for COMMD4 Gene

  • GC15P073345
  • GC15P073415
  • GC15P075628
  • GC15P052386

Summaries for COMMD4 Gene

GeneCards Summary for COMMD4 Gene

COMMD4 (COMM Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD4 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Gene Wiki entry for COMMD4 Gene

Additional gene information for COMMD4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD4 Gene

Genomics for COMMD4 Gene

GeneHancer (GH) Regulatory Elements for COMMD4 Gene

Promoters and enhancers for COMMD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J075335 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 663.4 +0.3 329 2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF610 COMMD4 MAN2C1 ENSG00000260274 SIN3A DNM1P35 SNUPN CLK3 FBXO22 GOLGA6D LOC105370902
GH15J075366 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.3 +32.9 32864 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MAN2C1 ENSG00000260274 SIN3A DNM1P35 EDC3 LOC441728 FBXO22 SNUPN CLK3 COMMD4
GH15J074380 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.6 -943.2 -943231 24.1 ZFP64 IRF4 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC ZC3H11A MEF2D CYP11A1 EDC3 ENSG00000260274 CLK3 MAN2C1 COMMD4 LOC101929333 SEMA7A ENSG00000212279 LOXL1
GH15J074539 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 19.3 -793.9 -793931 4.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B IRF4 YY1 ARID3B SIN3A MAN2C1 ENSG00000260274 EDC3 PML UBL7-AS1 CLK3 LOC101929333 ISLR
GH15J075449 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.9 +117.5 117465 8.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SIN3A ENSG00000276744 MAN2C1 ENSG00000260274 SNUPN EDC3 CLK3 DNM1P34 LOC101929333 FBXO22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMMD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COMMD4 gene promoter:
  • FOXO4
  • Zic3
  • Arnt
  • AhR
  • deltaCREB
  • CREB
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • GATA-3

Genomic Locations for COMMD4 Gene

Genomic Locations for COMMD4 Gene
7,334 bases
Plus strand
6,037 bases
Plus strand

Genomic View for COMMD4 Gene

Genes around COMMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD4 Gene

Proteins for COMMD4 Gene

  • Protein details for COMMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RBN4
    • H3BUL2
    • Q7L637
    • Q9NX43

    Protein attributes for COMMD4 Gene

    199 amino acids
    Molecular mass:
    21764 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7.

    Alternative splice isoforms for COMMD4 Gene


neXtProt entry for COMMD4 Gene

Post-translational modifications for COMMD4 Gene

  • Ubiquitination at posLast=180180 and posLast=5050
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD4 Gene

Domains & Families for COMMD4 Gene

Gene Families for COMMD4 Gene

Protein Domains for COMMD4 Gene


Suggested Antigen Peptide Sequences for COMMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD4: view

No data available for UniProtKB/Swiss-Prot for COMMD4 Gene

Function for COMMD4 Gene

Molecular function for COMMD4 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Phenotypes From GWAS Catalog for COMMD4 Gene

Gene Ontology (GO) - Molecular Function for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD4: view
genes like me logo Genes that share phenotypes with COMMD4: view

Animal Model Products

miRNA for COMMD4 Gene

miRTarBase miRNAs that target COMMD4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD4 Gene

Localization for COMMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD4 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with COMMD4: view

Pathways & Interactions for COMMD4 Gene

SuperPathways for COMMD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD4: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD4 Gene

Drugs & Compounds for COMMD4 Gene

No Compound Related Data Available

Transcripts for COMMD4 Gene

Unigene Clusters for COMMD4 Gene

COMM domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: - -

Relevant External Links for COMMD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD4 Gene

Protein differential expression in normal tissues from HIPED for COMMD4 Gene

This gene is overexpressed in Bone (8.9), Peripheral blood mononuclear cells (8.7), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMMD4 Gene

Protein tissue co-expression partners for COMMD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD4 Gene:


SOURCE GeneReport for Unigene cluster for COMMD4 Gene:


mRNA Expression by UniProt/SwissProt for COMMD4 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for COMMD4 Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with COMMD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD4 Gene

Orthologs for COMMD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD4 34 33
  • 99.83 (n)
(Canis familiaris)
Mammalia COMMD4 34 33
  • 91.29 (n)
(Bos Taurus)
Mammalia COMMD4 34 33
  • 87.77 (n)
(Mus musculus)
Mammalia Commd4 16 34 33
  • 86.93 (n)
(Rattus norvegicus)
Mammalia Commd4 33
  • 85.88 (n)
(Monodelphis domestica)
Mammalia COMMD4 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD4 34
  • 75 (a)
(Gallus gallus)
Aves COMMD4 34 33
  • 73.23 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd4 33
  • 67.68 (n)
Str.7325 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15129 33
(Danio rerio)
Actinopterygii commd4 34 33
  • 69.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9443 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001207 33
  • 48.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34039 34 33
  • 45.45 (n)
Species where no ortholog for COMMD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD4 Gene

Gene Tree for COMMD4 (if available)
Gene Tree for COMMD4 (if available)
Evolutionary constrained regions (ECRs) for COMMD4: view image

Paralogs for COMMD4 Gene Pseudogenes for COMMD4 Gene

genes like me logo Genes that share paralogs with COMMD4: view

No data available for Paralogs for COMMD4 Gene

Variants for COMMD4 Gene

Sequence variations from dbSNP and Humsavar for COMMD4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000233675 -- 75,334,743(+) A/C upstream_transcript_variant
rs1000302644 -- 75,339,554(+) C/T intron_variant
rs1000694685 -- 75,338,291(+) G/C intron_variant
rs1000890935 -- 75,338,466(+) A/C/G intron_variant
rs1002030519 -- 75,341,401(+) G/T genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD4 Gene

Variant ID Type Subtype PubMed ID
dgv2621n100 CNV gain 25217958
esv2749894 CNV deletion 23290073
nsv1116463 OTHER inversion 24896259
nsv977736 CNV duplication 23825009

Variation tolerance for COMMD4 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD4 Gene

Disorders for COMMD4 Gene

Additional Disease Information for COMMD4

No disorders were found for COMMD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD4 Gene

Publications for COMMD4 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 58
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 58
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 58
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for COMMD4 Gene

Sources for COMMD4 Gene

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