This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011] See more...

Aliases for COMMD3-BMI1 Gene

Aliases for COMMD3-BMI1 Gene

  • COMMD3-BMI1 Readthrough 2 3 5 13
  • Polycomb Group RING Finger Protein 4 3
  • COMMD3-BMI1 Read-Through Protein 3
  • Polycomb Complex Protein BMI-1 3
  • RING Finger Protein 51 3
  • COMMD3-BMI1 5
  • PCGF4 3
  • RNF51 3
  • BMI1 3

External Ids for COMMD3-BMI1 Gene

Previous GeneCards Identifiers for COMMD3-BMI1 Gene

  • GC10U901532
  • GC10P022606
  • GC10P022607

Summaries for COMMD3-BMI1 Gene

Entrez Gene Summary for COMMD3-BMI1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for COMMD3-BMI1 Gene

COMMD3-BMI1 (COMMD3-BMI1 Readthrough) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include RING-like zinc finger domain binding. An important paralog of this gene is BMI1.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COMMD3-BMI1 Gene

Genomics for COMMD3-BMI1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for COMMD3-BMI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMMD3-BMI1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COMMD3-BMI1

Genomic Locations for COMMD3-BMI1 Gene

Genomic Locations for COMMD3-BMI1 Gene
chr10:22,316,383-22,331,485
(GRCh38/hg38)
Size:
15,103 bases
Orientation:
Plus strand
chr10:22,605,312-22,620,414
(GRCh37/hg19)
Size:
15,103 bases
Orientation:
Plus strand

Genomic View for COMMD3-BMI1 Gene

Genes around COMMD3-BMI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD3-BMI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD3-BMI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD3-BMI1 Gene

Proteins for COMMD3-BMI1 Gene

  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMX3-R4GMX3_HUMAN
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    R4GMX3

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    469 amino acids
    Molecular mass:
    53294 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GN54-R4GN54_HUMAN
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    R4GN54

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    110 amino acids
    Molecular mass:
    12329 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q5T8Z1-Q5T8Z1_HUMAN
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    Q5T8Z1

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    53 amino acids
    Molecular mass:
    5961 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMW6-R4GMW6_HUMAN
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    R4GMW6

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    159 amino acids
    Molecular mass:
    18133 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COMMD3-BMI1 Gene

Post-translational modifications for COMMD3-BMI1 Gene

No Post-translational modifications

Other Protein References for COMMD3-BMI1 Gene

No data available for DME Specific Peptides for COMMD3-BMI1 Gene

Domains & Families for COMMD3-BMI1 Gene

Gene Families for COMMD3-BMI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD3-BMI1 Gene

genes like me logo Genes that share domains with COMMD3-BMI1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for COMMD3-BMI1 Gene

Function for COMMD3-BMI1 Gene

Gene Ontology (GO) - Molecular Function for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990841 promoter-specific chromatin binding IBA --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view
genes like me logo Genes that share phenotypes with COMMD3-BMI1: view

Animal Models for COMMD3-BMI1 Gene

MGI Knock Outs for COMMD3-BMI1:
  • Bmi1 Bmi1<tm1Brn>
  • Bmi1 Bmi1<tm1Ilw>
  • Bmi1 Bmi1<tm2Ilw>
  • Bmi1 Bmi1<tm1.1(KOMP)Vlcg>

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COMMD3-BMI1 Gene

Localization for COMMD3-BMI1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0016604 nuclear body IDA --
GO:0035102 PRC1 complex IBA --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for COMMD3-BMI1 Gene

Pathways & Interactions for COMMD3-BMI1 Gene

genes like me logo Genes that share pathways with COMMD3-BMI1: view

Pathways by source for COMMD3-BMI1 Gene

Interacting Proteins for COMMD3-BMI1 Gene

Gene Ontology (GO) - Biological Process for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006342 chromatin silencing IBA --
GO:0006814 sodium ion transport IEA --
GO:0036353 histone H2A-K119 monoubiquitination IBA --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view

No data available for SIGNOR curated interactions for COMMD3-BMI1 Gene

Drugs & Compounds for COMMD3-BMI1 Gene

No Compound Related Data Available

Transcripts for COMMD3-BMI1 Gene

mRNA/cDNA for COMMD3-BMI1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD3-BMI1

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD3-BMI1 Gene

No ASD Table

Relevant External Links for COMMD3-BMI1 Gene

GeneLoc Exon Structure for
COMMD3-BMI1

Expression for COMMD3-BMI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COMMD3-BMI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COMMD3-BMI1 Gene

This gene is overexpressed in Retina (19.8), Blymphocyte (15.6), CD8 Tcells (8.6), and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for COMMD3-BMI1 Gene



Protein tissue co-expression partners for COMMD3-BMI1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COMMD3-BMI1

genes like me logo Genes that share expression patterns with COMMD3-BMI1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD3-BMI1 Gene

Orthologs for COMMD3-BMI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD3-BMI1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 98 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia BMI1 30 31
  • 95.91 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia BMI1 30 31
  • 95.09 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Bmi1 30 17 31
  • 92.59 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Bmi1 30
  • 89.61 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
OneToMany
Chicken
(Gallus gallus)
Aves BMI1 30 31
  • 78.83 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 88 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia bmi1 30
  • 77.98 (n)
Zebrafish
(Danio rerio)
Actinopterygii bmi1a 31
  • 82 (a)
ManyToMany
bmi1b 30 31
  • 72.41 (n)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Psc 31
  • 8 (a)
ManyToMany
Su(z)2 31
  • 7 (a)
ManyToMany
Species where no ortholog for COMMD3-BMI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for COMMD3-BMI1 Gene

ENSEMBL:
Gene Tree for COMMD3-BMI1 (if available)
TreeFam:
Gene Tree for COMMD3-BMI1 (if available)

Paralogs for COMMD3-BMI1 Gene

Paralogs for COMMD3-BMI1 Gene

(9) SIMAP similar genes for COMMD3-BMI1 Gene using alignment to 4 proteins:

  • Q5T8Z1_HUMAN
  • R4GMW6_HUMAN
  • R4GMX3_HUMAN
  • R4GN54_HUMAN

Pseudogenes.org Pseudogenes for COMMD3-BMI1 Gene

genes like me logo Genes that share paralogs with COMMD3-BMI1: view

Variants for COMMD3-BMI1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COMMD3-BMI1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
736216 Benign: not provided 22,326,571(+) G/A INTRON_VARIANT
751854 Likely Benign: not provided 22,328,706(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for COMMD3-BMI1 Gene

Structural Variations from Database of Genomic Variants (DGV) for COMMD3-BMI1 Gene

Variant ID Type Subtype PubMed ID
dgv1002n54 CNV loss 21841781
dgv1003n54 CNV loss 21841781
dgv136n67 CNV gain 20364138
dgv137n67 CNV gain 20364138
esv27808 CNV gain 19812545
nsv1069031 CNV deletion 25765185
nsv1143626 CNV deletion 24896259
nsv550207 CNV loss 21841781
nsv825300 CNV gain 20364138
nsv951254 CNV duplication 24416366

Variation tolerance for COMMD3-BMI1 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD3-BMI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD3-BMI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD3-BMI1 Gene

Disorders for COMMD3-BMI1 Gene

No disorders were found for COMMD3-BMI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD3-BMI1 Gene

Publications for COMMD3-BMI1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  2. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3
  3. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3

Products for COMMD3-BMI1 Gene

Sources for COMMD3-BMI1 Gene