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This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
COMMD3-BMI1 (COMMD3-BMI1 Readthrough) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include RING-like zinc finger domain binding. An important paralog of this gene is BMI1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1990841 | promoter-specific chromatin binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
GO:0035102 | PRC1 complex | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Signaling pathways regulating pluripotency of stem cells | ||
3 | Transcriptional misregulation in cancer | ||
4 | Validated targets of C-MYC transcriptional activation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
GO:0006342 | chromatin silencing | IBA | -- |
GO:0006814 | sodium ion transport | IEA | -- |
GO:0036353 | histone H2A-K119 monoubiquitination | IBA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | BMI1 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | BMI1 30 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Bmi1 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Bmi1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | BMI1 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bmi1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | bmi1a 31 |
|
ManyToMany | |
bmi1b 30 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Psc 31 |
|
ManyToMany | |
Su(z)2 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1002n54 | CNV | loss | 21841781 |
dgv1003n54 | CNV | loss | 21841781 |
dgv136n67 | CNV | gain | 20364138 |
dgv137n67 | CNV | gain | 20364138 |
esv27808 | CNV | gain | 19812545 |
nsv1069031 | CNV | deletion | 25765185 |
nsv1143626 | CNV | deletion | 24896259 |
nsv550207 | CNV | loss | 21841781 |
nsv825300 | CNV | gain | 20364138 |
nsv951254 | CNV | duplication | 24416366 |
No disorders were found for COMMD3-BMI1 Gene.