Aliases for COMMD2 Gene

Aliases for COMMD2 Gene

  • COMM Domain Containing 2 2 3 5
  • COMM Domain-Containing Protein 2 3 4
  • HSPC042 3

External Ids for COMMD2 Gene

Previous GeneCards Identifiers for COMMD2 Gene

  • GC03M150780
  • GC03M150941
  • GC03M149448
  • GC03M146829

Summaries for COMMD2 Gene

GeneCards Summary for COMMD2 Gene

COMMD2 (COMM Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for COMMD2 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Additional gene information for COMMD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COMMD2 Gene

Genomics for COMMD2 Gene

GeneHancer (GH) Regulatory Elements for COMMD2 Gene

Promoters and enhancers for COMMD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMMD2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COMMD2

Top Transcription factor binding sites by QIAGEN in the COMMD2 gene promoter:
  • E47
  • FAC1
  • Lmo2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • SRF
  • SRF (504 AA)
  • SRY
  • Tal-1beta

Genomic Locations for COMMD2 Gene

Genomic Locations for COMMD2 Gene
14,041 bases
Minus strand
14,030 bases
Minus strand

Genomic View for COMMD2 Gene

Genes around COMMD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD2 Gene

Proteins for COMMD2 Gene

  • Protein details for COMMD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q561V4
    • Q9H3L5
    • Q9Y5V1

    Protein attributes for COMMD2 Gene

    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain) (PubMed:15799966). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7 (PubMed:28892079, PubMed:15799966, PubMed:21778237, PubMed:23563313, PubMed:23637203, PubMed:25355947).
    • Sequence=AAD39913.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for COMMD2 Gene


neXtProt entry for COMMD2 Gene

Post-translational modifications for COMMD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COMMD2 Gene

Domains & Families for COMMD2 Gene

Gene Families for COMMD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD2 Gene

  • HCaRG

Suggested Antigen Peptide Sequences for COMMD2 Gene

GenScript: Design optimal peptide antigens:
  • COMM domain-containing protein 2 (COMD2_HUMAN)
  • COMMD2 protein (Q561V4_HUMAN)
genes like me logo Genes that share domains with COMMD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for COMMD2 Gene

Function for COMMD2 Gene

Molecular function for COMMD2 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD2 Gene

Gene Ontology (GO) - Molecular Function for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD2: view
genes like me logo Genes that share phenotypes with COMMD2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD2 Gene

Localization for COMMD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD2 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD2: view

Pathways & Interactions for COMMD2 Gene

PathCards logo

SuperPathways for COMMD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for COMMD2 Gene

Drugs & Compounds for COMMD2 Gene

No Compound Related Data Available

Transcripts for COMMD2 Gene

mRNA/cDNA for COMMD2 Gene

15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -

Relevant External Links for COMMD2 Gene

GeneLoc Exon Structure for

Expression for COMMD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COMMD2 Gene

Protein differential expression in normal tissues from HIPED for COMMD2 Gene

This gene is overexpressed in Monocytes (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMMD2 Gene

Protein tissue co-expression partners for COMMD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COMMD2

SOURCE GeneReport for Unigene cluster for COMMD2 Gene:


mRNA Expression by UniProt/SwissProt for COMMD2 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for COMMD2 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with COMMD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD2 Gene

Orthologs for COMMD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD2 31 30
  • 99.16 (n)
(Canis familiaris)
Mammalia COMMD2 31 30
  • 90.62 (n)
(Bos Taurus)
Mammalia COMMD2 31 30
  • 90.28 (n)
(Ornithorhynchus anatinus)
Mammalia COMMD2 31
  • 88 (a)
(Mus musculus)
Mammalia Commd2 17 31 30
  • 87.27 (n)
(Monodelphis domestica)
Mammalia COMMD2 31
  • 87 (a)
(Rattus norvegicus)
Mammalia Commd2 30
  • 86.77 (n)
(Gallus gallus)
Aves COMMD2 31 30
  • 75.38 (n)
(Anolis carolinensis)
Reptilia COMMD2 31
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd2 30
  • 70.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4659 30
(Danio rerio)
Actinopterygii commd2 31 30
  • 68.01 (n)
wufb12e01 30
fruit fly
(Drosophila melanogaster)
Insecta CG7168 31
  • 28 (a)
Species where no ortholog for COMMD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD2 Gene

Gene Tree for COMMD2 (if available)
Gene Tree for COMMD2 (if available)
Evolutionary constrained regions (ECRs) for COMMD2: view image

Paralogs for COMMD2 Gene

No data available for Paralogs for COMMD2 Gene

Variants for COMMD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COMMD2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1546732 - p.Gln177His
rs9843784 - p.Ile113Leu

Additional dbSNP identifiers (rs#s) for COMMD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for COMMD2 Gene

Variant ID Type Subtype PubMed ID
esv34142 CNV loss 18971310
nsv829754 CNV gain 17160897

Variation tolerance for COMMD2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD2 Gene

Disorders for COMMD2 Gene

Additional Disease Information for COMMD2

No disorders were found for COMMD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD2 Gene

Publications for COMMD2 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 54
  2. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. (PMID: 28892079) McNally KE … Cullen PJ (Nature cell biology 2017) 3 4 54
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 54
  4. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 54
  5. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 54

Products for COMMD2 Gene

Sources for COMMD2 Gene