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Aliases for COMMD10 Gene

Aliases for COMMD10 Gene

  • COMM Domain Containing 10 2 3 5
  • COMM Domain-Containing Protein 10 3
  • PTD002 3

External Ids for COMMD10 Gene

Previous GeneCards Identifiers for COMMD10 Gene

  • GC05P115497
  • GC05P115448
  • GC05P110601

Summaries for COMMD10 Gene

GeneCards Summary for COMMD10 Gene

COMMD10 (COMM Domain Containing 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD10 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Additional gene information for COMMD10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD10 Gene

Genomics for COMMD10 Gene

GeneHancer (GH) Regulatory Elements for COMMD10 Gene

Promoters and enhancers for COMMD10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J116083 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 650.7 +1.5 1484 2.5 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 SLC30A9 POLR2B ENSG00000271918 GC05M116084 COMMD10 ENSG00000250015 ENSG00000272265
GH05J116077 Promoter 0.8 EPDnew 650.4 -8.3 -8276 0.1 ZFHX2 EGR1 L3MBTL2 ZSCAN5C SCRT2 MGA EGR2 COMMD10 LVRN ATG12 AP3S1 TMED7 ENSG00000272265 RPS25P6
GH05J116358 Enhancer 1.1 Ensembl ENCODE 13.7 +276.6 276585 3.7 HDGF PKNOX1 ATF1 IRF4 TCF12 ZNF143 ATF7 RUNX3 JUNB REST COMMD10 SEMA6A-AS1 ENSG00000271918 LOC101927190 ENSG00000250015
GH05J116089 Enhancer 0.5 ENCODE 16.6 +6.6 6553 1.9 MEF2D VEZF1 MYNN HMBOX1 COMMD10 ENSG00000271918 ENSG00000272265 GC05P116137
GH05J116076 Enhancer 1.1 FANTOM5 Ensembl ENCODE 6.5 -6.9 -6927 0.6 BACH1 BATF NFATC1 EED ATF7 ETV6 IKZF2 RUNX3 SRF JUNB ENSG00000272265 LVRN ATG12 AP3S1 TMED7 COMMD10 ENSG00000271918 RPS25P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMMD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COMMD10 gene promoter:
  • Lmo2
  • POU2F1a
  • POU2F1
  • C/EBPbeta
  • CUTL1
  • Chx10
  • PPAR-gamma1
  • PPAR-gamma2
  • Pax-4a
  • Pax-6

Genomic Locations for COMMD10 Gene

Genomic Locations for COMMD10 Gene
329,118 bases
Plus strand
327,772 bases
Plus strand

Genomic View for COMMD10 Gene

Genes around COMMD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD10 Gene

Proteins for COMMD10 Gene

  • Protein details for COMMD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • D3DT07
    • Q9P077

    Protein attributes for COMMD10 Gene

    202 amino acids
    Molecular mass:
    22966 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    • Sequence=AAF28983.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COMMD10 Gene

Post-translational modifications for COMMD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COMMD10 Gene

Domains & Families for COMMD10 Gene

Gene Families for COMMD10 Gene

Protein Domains for COMMD10 Gene


Suggested Antigen Peptide Sequences for COMMD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD10: view

No data available for UniProtKB/Swiss-Prot for COMMD10 Gene

Function for COMMD10 Gene

Molecular function for COMMD10 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD10 Gene

Gene Ontology (GO) - Molecular Function for COMMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD10: view
genes like me logo Genes that share phenotypes with COMMD10: view

Animal Models for COMMD10 Gene

MGI Knock Outs for COMMD10:
  • Commd10 Commd10<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for COMMD10 Gene

miRTarBase miRNAs that target COMMD10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COMMD10 Gene

Localization for COMMD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD10 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD10: view

Pathways & Interactions for COMMD10 Gene

SuperPathways for COMMD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD10: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD10 Gene

Drugs & Compounds for COMMD10 Gene

No Compound Related Data Available

Transcripts for COMMD10 Gene

Unigene Clusters for COMMD10 Gene

COMM domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COMMD10

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD10 Gene

No ASD Table

Relevant External Links for COMMD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD10 Gene

Protein differential expression in normal tissues from HIPED for COMMD10 Gene

This gene is overexpressed in Bone marrow stromal cell (8.1) and Monocytes (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMMD10 Gene

Protein tissue co-expression partners for COMMD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD10 Gene:


SOURCE GeneReport for Unigene cluster for COMMD10 Gene:


mRNA Expression by UniProt/SwissProt for COMMD10 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for COMMD10 Gene

  • Blood(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with COMMD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD10 Gene

Orthologs for COMMD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD10 34 33
  • 99.34 (n)
(Bos Taurus)
Mammalia COMMD10 34 33
  • 92.41 (n)
(Canis familiaris)
Mammalia COMMD10 34 33
  • 90.76 (n)
(Rattus norvegicus)
Mammalia Commd10 33
  • 86.47 (n)
(Mus musculus)
Mammalia Commd10 16 34 33
  • 85.15 (n)
(Ornithorhynchus anatinus)
Mammalia COMMD10 34
  • 80 (a)
(Monodelphis domestica)
Mammalia COMMD10 34
  • 79 (a)
(Gallus gallus)
Aves COMMD10 34 33
  • 72.29 (n)
(Anolis carolinensis)
Reptilia COMMD10 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd10 33
  • 74.58 (n)
Str.16149 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21108 33
(Danio rerio)
Actinopterygii commd10 33
  • 60.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2371 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5208 34
  • 44 (a)
Species where no ortholog for COMMD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD10 Gene

Gene Tree for COMMD10 (if available)
Gene Tree for COMMD10 (if available)
Evolutionary constrained regions (ECRs) for COMMD10: view image

Paralogs for COMMD10 Gene

No data available for Paralogs for COMMD10 Gene

Variants for COMMD10 Gene

Sequence variations from dbSNP and Humsavar for COMMD10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000000549 -- 116,268,126(+) G/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000001296 -- 116,316,159(+) A/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000006151 -- 116,444,081(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000006695 -- 116,206,511(+) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000009248 -- 116,239,424(+) T/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD10 Gene

Variant ID Type Subtype PubMed ID
dgv10028n54 CNV gain 21841781
dgv10029n54 CNV loss 21841781
dgv1129e214 CNV loss 21293372
dgv1639e212 CNV loss 25503493
dgv5789n100 CNV gain 25217958
dgv5790n100 CNV loss 25217958
dgv5791n100 CNV loss 25217958
dgv5792n100 CNV loss 25217958
dgv954e201 CNV deletion 23290073
esv1348644 CNV deletion 17803354
esv2422101 CNV deletion 20811451
esv2552964 CNV insertion 19546169
esv2632290 CNV deletion 19546169
esv2665054 CNV deletion 23128226
esv2670584 CNV deletion 23128226
esv2677603 CNV deletion 23128226
esv2730631 CNV deletion 23290073
esv2730633 CNV deletion 23290073
esv2730634 CNV deletion 23290073
esv2752058 CNV loss 17911159
esv2759371 CNV loss 17122850
esv2759372 CNV loss 17122850
esv2760969 CNV loss 21179565
esv2762538 CNV loss 21179565
esv2763487 CNV gain 21179565
esv32605 CNV gain 17666407
esv33800 CNV loss 17666407
esv33867 CNV gain 17666407
esv34146 CNV loss 18971310
esv34342 CNV loss 17911159
esv34428 CNV loss 17911159
esv3570367 CNV loss 25503493
esv3570368 CNV loss 25503493
esv3606378 CNV loss 21293372
esv3606379 CNV gain 21293372
esv3606380 CNV loss 21293372
esv3606381 CNV loss 21293372
esv3606383 CNV gain 21293372
esv3606385 CNV loss 21293372
esv3606386 CNV gain 21293372
esv3606387 CNV loss 21293372
esv3606389 CNV loss 21293372
esv3606390 CNV loss 21293372
esv3606391 CNV loss 21293372
esv3606392 CNV loss 21293372
esv3606393 CNV gain 21293372
esv3606394 CNV loss 21293372
esv3606395 CNV gain 21293372
esv3606396 CNV loss 21293372
esv3606397 CNV loss 21293372
esv3606398 CNV loss 21293372
esv3890718 CNV loss 25118596
esv3890719 CNV loss 25118596
esv3890720 CNV loss 25118596
nsv1017983 CNV loss 25217958
nsv1018714 CNV loss 25217958
nsv1018738 CNV loss 25217958
nsv1021381 CNV loss 25217958
nsv1023390 CNV loss 25217958
nsv1028663 CNV loss 25217958
nsv1029334 CNV loss 25217958
nsv1029470 CNV loss 25217958
nsv1032531 CNV gain 25217958
nsv1034438 CNV loss 25217958
nsv10744 CNV loss 18304495
nsv10745 CNV loss 18304495
nsv10746 CNV loss 18304495
nsv1111302 CNV tandem duplication 24896259
nsv1123976 CNV deletion 24896259
nsv1161290 CNV deletion 26073780
nsv1161291 CNV deletion 26073780
nsv328049 CNV deletion 16902084
nsv442961 CNV loss 18776908
nsv462401 CNV loss 19166990
nsv462402 CNV loss 19166990
nsv475698 CNV novel sequence insertion 20440878
nsv4967 CNV insertion 18451855
nsv509991 OTHER sequence alteration 20534489
nsv514321 CNV loss 21397061
nsv515611 CNV gain+loss 19592680
nsv517704 CNV loss 19592680
nsv519321 CNV loss 19592680
nsv521050 CNV loss 19592680
nsv524812 CNV loss 19592680
nsv527320 CNV loss 19592680
nsv527484 CNV loss 19592680
nsv599480 CNV loss 21841781
nsv599483 CNV loss 21841781
nsv599484 CNV loss 21841781
nsv818377 CNV loss 17921354
nsv823185 CNV loss 20364138
nsv958320 CNV deletion 24416366
nsv980718 CNV duplication 23825009

Variation tolerance for COMMD10 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD10 Gene

Disorders for COMMD10 Gene

Additional Disease Information for COMMD10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COMMD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD10 Gene

Publications for COMMD10 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 58
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 58
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 58
  4. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S … Arnett DK (Pharmacogenetics and genomics 2012) 3 44 58
  5. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 58

Products for COMMD10 Gene

Sources for COMMD10 Gene

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