Aliases for COLCA2 Gene

Aliases for COLCA2 Gene

  • Colorectal Cancer Associated 2 2 3 5
  • Cancer Susceptibility Candidate Protein 13 3 4
  • Colorectal Cancer-Associated Protein 2 3 4
  • Cancer Susceptibility Candidate 13 2 3
  • C11orf93 3 4
  • CASC13 3 4
  • Chromosome 11 Open Reading Frame 93 2
  • Colorectal Cancer Associated Two 3
  • LOH11CR1G 3

External Ids for COLCA2 Gene

Previous HGNC Symbols for COLCA2 Gene

  • C11orf93

Previous GeneCards Identifiers for COLCA2 Gene

  • GC11P111170

Summaries for COLCA2 Gene

GeneCards Summary for COLCA2 Gene

COLCA2 (Colorectal Cancer Associated 2) is a Protein Coding gene. Diseases associated with COLCA2 include Colorectal Cancer.

Additional gene information for COLCA2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COLCA2 Gene

Genomics for COLCA2 Gene

GeneHancer (GH) Regulatory Elements for COLCA2 Gene

Promoters and enhancers for COLCA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111298 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 776.9 +1.2 1173 2.5 RAD21 CTCF ELF3 RXRA GATAD2A ZNF7 LARP7 KMT2B KAT7 TRIM22 COLCA2 C11orf53 COLCA1
GH11J111357 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26.7 +66.4 66358 15.7 ZNF24 SP1 CTCF FOXA1 MLX RBPJ NR2F1 NR2F6 MIXL1 ETV6 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 lnc-BTG4-3 MIR4491
GH11J111375 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 17.5 +79.9 79941 5.1 ZNF24 ZBTB40 POLR2A ETV6 RELA ZNF652 NKRF MLLT1 ZNF687 CREM POU2AF1 lnc-BTG4-3 COLCA1 COLCA2 ENSG00000255093 BTG4 C11orf88 MIR34B MIR34C MIR4491
GH11J111302 Enhancer 1 Ensembl ENCODE dbSUPER 27 +4.3 4255 2.8 CTCF HLF RAD21 ELF3 SP1 RXRA PRDM10 GATAD2A NFKBIZ ZNF205 COLCA2 C11orf53 COLCA1
GH11J111922 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +626.7 626663 5.6 SP1 ZBTB40 FOXA1 RBPJ SMARCE1 POLR2A NR2F6 MYC NFYC HLF C11orf52 DIXDC1 CRYAB PPP2R1B NKAPD1 COLCA2 SDHD HSPB2-C11orf52
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COLCA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for COLCA2 Gene

Genomic Locations for COLCA2 Gene
10,190 bases
Plus strand
9,896 bases
Plus strand

Genomic View for COLCA2 Gene

Genes around COLCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COLCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COLCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COLCA2 Gene

Proteins for COLCA2 Gene

  • Protein details for COLCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Colorectal cancer-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • E9PMJ8
    • Q2TBJ3
    • V5LD62
    • V5LDI3
    • V5LDV1
    • V5LE09
    • V5LEU3

    Protein attributes for COLCA2 Gene

    154 amino acids
    Molecular mass:
    16850 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10080.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AP002448; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for COLCA2 Gene


neXtProt entry for COLCA2 Gene

Post-translational modifications for COLCA2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for COLCA2 Gene

Domains & Families for COLCA2 Gene

Gene Families for COLCA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COLCA2 Gene

genes like me logo Genes that share domains with COLCA2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for COLCA2 Gene

Function for COLCA2 Gene

Phenotypes From GWAS Catalog for COLCA2 Gene

genes like me logo Genes that share phenotypes with COLCA2: view

Animal Models for COLCA2 Gene

MGI Knock Outs for COLCA2:
  • Colca2 Colca2<tm1b(NCOM)Mfgc>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COLCA2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for COLCA2 Gene

Localization for COLCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COLCA2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COLCA2 gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for COLCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24154973
genes like me logo Genes that share ontologies with COLCA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COLCA2 Gene

Pathways & Interactions for COLCA2 Gene

PathCards logo

SuperPathways for COLCA2 Gene

No Data Available

Interacting Proteins for COLCA2 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000484135 for COLCA2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for COLCA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for COLCA2 Gene

Drugs & Compounds for COLCA2 Gene

No Compound Related Data Available

Transcripts for COLCA2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COLCA2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COLCA2 Gene

No ASD Table

Relevant External Links for COLCA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COLCA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COLCA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of COLCA2 Gene:


mRNA Expression by UniProt/SwissProt for COLCA2 Gene:

Tissue specificity: Expressed in many cell types of epithelial, mesenchymal and hematopoietic origins.

Evidence on tissue expression from TISSUES for COLCA2 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with COLCA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for COLCA2 Gene

Orthologs for COLCA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COLCA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COLCA2 33 32
  • 99.47 (n)
(Canis familiaris)
Mammalia COLCA2 33 32
  • 84.46 (n)
(Bos Taurus)
Mammalia LOC100294918 32
  • 83 (n)
(Mus musculus)
Mammalia Gm684 33 32
  • 78.34 (n)
Colca2 17
(Rattus norvegicus)
Mammalia RGD1563866 32
  • 77.73 (n)
(Ornithorhynchus anatinus)
Mammalia COLCA2 33
  • 27 (a)
(Gallus gallus)
Aves LOC101751781 32
  • 57.81 (n)
  • 38 (a)
(Anolis carolinensis)
Reptilia COLCA2 33
  • 21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734888 32
  • 52.95 (n)
Species where no ortholog for COLCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COLCA2 Gene

Gene Tree for COLCA2 (if available)
Gene Tree for COLCA2 (if available)
Evolutionary constrained regions (ECRs) for COLCA2: view image

Paralogs for COLCA2 Gene

No data available for Paralogs for COLCA2 Gene

Variants for COLCA2 Gene

Sequence variations from dbSNP and Humsavar for COLCA2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000366266 -- 111,306,061(+) G/A intron_variant
rs1000914326 -- 111,305,993(+) A/G intron_variant
rs1001133494 -- 111,299,373(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001245819 -- 111,305,511(+) A/C intron_variant
rs1001263073 -- 111,305,558(+) AAA/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COLCA2 Gene

Variant ID Type Subtype PubMed ID
esv3627734 CNV gain 21293372

Variation tolerance for COLCA2 Gene

Gene Damage Index Score: 0.50; 10.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COLCA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COLCA2 Gene

Disorders for COLCA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COLCA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for COLCA2

genes like me logo Genes that share disorders with COLCA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COLCA2 Gene

Publications for COLCA2 Gene

  1. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. (PMID: 24154973) Peltekova VD … Hudson TJ (International journal of cancer 2014) 3 4 56
  2. Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations. (PMID: 21071539) He J … Haiman CA (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011) 2 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. (PMID: 24836286) Zhang B … Zheng W (Nature genetics 2014) 3 56

Products for COLCA2 Gene

Sources for COLCA2 Gene