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COL23A1 is a member of the transmembrane collagens, a subfamily of the nonfibrillar collagens that contain a single pass hydrophobic transmembrane domain (Banyard et al., 2003 [PubMed 12644459]).[supplied by OMIM, Mar 2008]
COL23A1 (Collagen Type XXIII Alpha 1 Chain) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. An important paralog of this gene is COL5A1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005201 | extracellular matrix structural constituent | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0030020 | extracellular matrix structural constituent conferring tensile strength | RCA | 25037231 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005581 | collagen trimer | IEA | -- |
GO:0005587 | collagen type IV trimer | IBA | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
2 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
Blood Coagulation Cascade
.46
|
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Degradation of the extracellular matrix | ||
5 | Phospholipase-C Pathway |
Phospholipase-C Pathway
.56
|
PTEN Pathway
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030198 | extracellular matrix organization | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | COL23A1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | COL23A1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | COL23A1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Col23a1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Col23a1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | COL23A1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | COL23A1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | COL23A1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | COL23A1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC101886266 30 |
|
||
si:dkey-117n7.4 31 |
|
ManyToMany | |||
zgc:113232 31 |
|
ManyToMany | |||
si:ch211-106n13.3 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | col-135 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs890802 | - | p.Thr287Ala |
No disorders were found for COL23A1 Gene.