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This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos synd... See more...
Aliases for COL1A1 Gene
Aliases for COL1A1 Gene
External Ids for COL1A1 Gene
- HGNC: 2197
- Entrez Gene: 1277
- Ensembl: ENSG00000108821
- OMIM: 120150
- UniProtKB: P02452
Previous GeneCards Identifiers for COL1A1 Gene
- GC17M047864
- GC17M050742
- GC17M048602
- GC17M048736
- GC17M045617
- GC17M048260
- GC17M043632
Summaries for COL1A1 Gene
-
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
GeneCards Summary for COL1A1 Gene
COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I. Among its related pathways are Integrin Pathway and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding. An important paralog of this gene is COL2A1.
UniProtKB/Swiss-Prot Summary for COL1A1 Gene
-
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Additional gene information for COL1A1 Gene
- HGNC(2197)
- Entrez Gene(1277)
- Ensembl(ENSG00000108821)
- OMIM(120150)
- UniProtKB(P02452)
- Open Targets Platform(ENSG00000108821)
- Monarch Initiative
- Search for COL1A1 at DataMed
- Search for COL1A1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COL1A1 Gene
Genomics for COL1A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for COL1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around COL1A1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COL1A1
- Top Transcription factor binding sites by QIAGEN in the COL1A1 gene promoter:
-
- AREB6
- c-Myb
- GATA-1
- GR
- GR-alpha
- GR-beta
- HSF1 (long)
- HSF1short
- USF-1
- USF1
Genomic Locations for COL1A1 Gene
Genomic Locations for COL1A1 Gene
- chr17:50,184,096-50,201,649
- (GRCh38/hg38)
- Size:
- 17,554 bases
- Orientation:
- Minus strand
- chr17:48,260,650-48,279,000
- (GRCh37/hg19)
- Size:
- 18,351 bases
- Orientation:
- Minus strand
Genomic View for COL1A1 Gene
Genes around COL1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by HGNC
- 17q21.33 by Entrez Gene
- 17q21.33 by Ensembl
COL1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COL1A1 Gene
Proteins for COL1A1 Gene
-
Protein details for COL1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02452-CO1A1_HUMAN
- Recommended name:
- Collagen alpha-1(I) chain
- Protein Accession:
- P02452
- O76045
- P78441
- Q13896
- Q13902
- Q13903
- Q14037
- Q14992
- Q15176
- Q15201
- Q16050
- Q59F64
- Q7KZ30
- Q7KZ34
- Q8IVI5
- Q8N473
- Q9UML6
- Q9UMM7
Protein attributes for COL1A1 Gene
- Size:
- 1464 amino acids
- Molecular mass:
- 138941 Da
- Quaternary structure:
-
- Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity). Interacts with TRAM2 (PubMed:14749390). Interacts with MFAP4 in a Ca (2+)-dependent manner (By similarity).
- SequenceCaution:
-
- Sequence=BAD92834.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for COL1A1 Gene
Post-translational modifications for COL1A1 Gene
- Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
- Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.
- Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.
- O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.
-
Glycosylation at Lys265, Thr478, Lys1108, Thr1234, and Asn1365
- NX_P02452 (NX_P02452-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- CO1A1_HUMAN (1125)
Other Protein References for COL1A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
SouthernBiotech
- Mouse Anti-Human Type I Collagen-UNLB (1441-01)
- Goat Anti-Type I Collagen-UNLB
- Mouse Anti-Human Type I Collagen-FITC
- Mouse Anti-Human Type I Collagen-UNLB (1440-01)
- Mouse Anti-Human Type I Collagen-BIOT
- Goat Anti-Type I Collagen-BIOT
- Mouse Anti-Human Type I Collagen-HRP
- Goat Anti-Type I Collagen-FITC
- Goat Anti-Type I Collagen-AF488
-
Custom Antibody ServicesOriGene Antibodies for COL1A1
- AM01090PU-N
- AM31694PU-N
- AM32237PU-N
- AP05388PU-N
- AP05393PU-N
- AP09014PU-N
- AP22813AF-N
- AP31891PU-N
- AP31892PU-N
- BM2248
- BM331
- BP1092P
- BP2156
- BP8000
- BP8000S
- BP8002
- BP8002S
- BP8003
- BP8003S
- BP8004
- BP8005
- BP8005S
- BP8006
- BP8006S
- BP8007
- BP8007S
- BP8028
- R1038
- R1038B
- R1038X
- SP2175B
- SP2175P
- TA309096
- TA309097
- TA336830
- TA336831
- TA342813
- TA342814
- TA354178
- Novus Biologicals Antibodies for COL1A1
-
Abcam antibodies for COL1A1
- Invitrogen Antibodies for COL1A1 (AFLGC-COL1A1)
-
Custom Antibody ServicesProSci Antibodies for COL1A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for COL1A1
Protein Products
-
OriGene Purified Proteins for COL1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for COL1A1
- Origene Custom Protein Services for COL1A1
-
Abcam proteins for COL1A1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for COL1A1
- Novus Biologicals ELISA Kits for COL1A1
- antibodies-online: Show 58 available COL1A1 Elisa Kits ranked by validation data
- Compare Top COL1A1 Elisa Kits
-
Quality Products:
- ABIN6730967
- ABIN1114244
- ABIN418649
- ABIN831819
- ABIN1569077
- ABIN5520354
- ABIN5526790
- ABIN5668503
- ABIN5591935
- ABIN5653098
- ABIN426159
- ABIN831820
- ABIN1569078
- ABIN5591936
- ABIN5653099
- ABIN6254340
- ABIN454771
- ABIN2543135
- ABIN4968173
- ABIN6203493
- ABIN1114241
- ABIN416528
- ABIN1569079
- ABIN368008
- ABIN578773
- ABIN5706339
- ABIN5591937
- ABIN5653100
- ABIN6254341
- ABIN2543136
- ABIN578772
- ABIN5591933
-
Boster Bio ELISA Kits for COL1A1
-
Abcam assays for COL1A1
No data available for DME Specific Peptides for COL1A1 Gene
Domains & Families for COL1A1 Gene
Gene Families for COL1A1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for COL1A1 Gene
- InterPro:
- Blocks:
-
- Collagen triple helix repeat
- Collagen helix repeat
- von Willebrand factor, type C
- Fibrillar collagen, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for COL1A1 Gene
- GenScript: Design optimal peptide antigens:
-
- Alpha-1 type I collagen (CO1A1_HUMAN)
- Collagen, type I, alpha 1, isoform CRA_a (D3DTX7_HUMAN)
- Type I collagen alpha 1(I) chain (O00604_HUMAN)
- Type I procollagen alpha 1 chain (Q16053_HUMAN)
- Collagen type I alpha 1 (Q6LAN8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P02452UniProtKB/Swiss-Prot:
CO1A1_HUMAN :- The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
- Belongs to the fibrillar collagen family.
- Domain:
-
- The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
- Family:
-
- Belongs to the fibrillar collagen family.
Function for COL1A1 Gene
Molecular function for COL1A1 Gene
- UniProtKB/Swiss-Prot Function:
- Type I collagen is a member of group I collagen (fibrillar forming collagen).
- GENATLAS Biochemistry:
- collagen type I,alpha 1,fibril forming,putative downregulated c-Myc target gene,
Phenotypes From GWAS Catalog for COL1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 19932771 |
| GO:0005201 | extracellular matrix structural constituent | IBA | 21873635 |
| GO:0005515 | protein binding | IEA,IPI | 14749390 |
| GO:0030020 | extracellular matrix structural constituent conferring tensile strength | RCA | 20551380 |
| GO:0042802 | identical protein binding | IEA,IDA | 17211858 |
Phenotypes for COL1A1 Gene
- MGI mutant phenotypes for COL1A1:
-
inferred from 90 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for COL1A1:
Animal Models for COL1A1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for COL1A1 - Select products 50% OFF >
- * COL1A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for COL1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COL1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for COL1A1
miRNA for COL1A1 Gene
- miRTarBase miRNAs that target COL1A1
-
- hsa-miR-29b-3p (MIRT000100)
- hsa-miR-29c-3p (MIRT000928)
- mmu-miR-29a-3p (MIRT003677)
- mmu-miR-29b-3p (MIRT003678)
- hsa-miR-143-3p (MIRT004242)
- rno-miR-29b-3p (MIRT007448)
- hsa-miR-133a-3p (MIRT021714)
- hsa-miR-124-3p (MIRT022587)
- hsa-miR-412-3p (MIRT440917)
- hsa-miR-4776-5p (MIRT659428)
- hsa-miR-4800-5p (MIRT659429)
- hsa-miR-3619-3p (MIRT659430)
- hsa-miR-7162-5p (MIRT659431)
- hsa-miR-516b-3p (MIRT659432)
- hsa-miR-516a-3p (MIRT659433)
- mmu-let-7e-5p (MIRT732893)
- hsa-miR-29b-1-5p (MIRT734148)
- hsa-miR-185-5p (MIRT734240)
- hsa-miR-129-5p (MIRT734322)
- hsa-miR-1184 (MIRT735889)
- hsa-miR-1249-5p (MIRT736423)
- hsa-miR-1253 (MIRT736537)
- hsa-miR-1301-3p (MIRT737249)
- hsa-miR-1587 (MIRT737915)
- hsa-miR-1827 (MIRT738093)
- hsa-miR-2278 (MIRT739125)
- hsa-miR-2392 (MIRT739163)
- hsa-miR-2467-3p (MIRT739256)
- hsa-miR-3122 (MIRT739979)
- hsa-miR-3150b-3p (MIRT740301)
- hsa-miR-3605-5p (MIRT741508)
- hsa-miR-3609 (MIRT741530)
- hsa-miR-3620-5p (MIRT741743)
- hsa-miR-363-5p (MIRT741824)
- hsa-miR-3665 (MIRT742042)
- hsa-miR-3911 (MIRT742844)
- hsa-miR-3913-5p (MIRT742861)
- hsa-miR-3942-3p (MIRT743150)
- hsa-miR-3978 (MIRT743224)
- hsa-miR-4251 (MIRT743314)
- hsa-miR-4257 (MIRT743392)
- hsa-miR-4306 (MIRT743892)
- hsa-miR-4324 (MIRT744066)
- hsa-miR-4433b-3p (MIRT744374)
- hsa-miR-4455 (MIRT744722)
- hsa-miR-4468 (MIRT744915)
- hsa-miR-4492 (MIRT745278)
- hsa-miR-4498 (MIRT745359)
- hsa-miR-450a-1-3p (MIRT745567)
- hsa-miR-4524a-3p (MIRT745839)
- hsa-miR-4533 (MIRT746001)
- hsa-miR-4644 (MIRT746364)
- hsa-miR-4656 (MIRT746649)
- hsa-miR-4660 (MIRT746684)
- hsa-miR-4675 (MIRT746878)
- hsa-miR-4736 (MIRT747993)
- hsa-miR-4741 (MIRT748115)
- hsa-miR-4747-5p (MIRT748229)
- hsa-miR-4779 (MIRT748729)
- hsa-miR-4784 (MIRT748818)
- hsa-miR-4786-3p (MIRT748862)
- hsa-miR-5001-5p (MIRT749352)
- hsa-miR-5008-5p (MIRT749441)
- hsa-miR-503-5p (MIRT749539)
- hsa-miR-5047 (MIRT749565)
- hsa-miR-5091 (MIRT749659)
- hsa-miR-5192 (MIRT749938)
- hsa-miR-5196-5p (MIRT750013)
- hsa-miR-548ah-5p (MIRT750515)
- hsa-miR-5699-5p (MIRT751325)
- hsa-miR-5739 (MIRT751410)
- hsa-miR-6513-5p (MIRT753248)
- hsa-miR-6515-5p (MIRT753282)
- hsa-miR-6745 (MIRT754452)
- hsa-miR-6747-5p (MIRT754515)
- hsa-miR-6752-5p (MIRT754623)
- hsa-miR-6758-5p (MIRT754868)
- hsa-miR-6770-5p (MIRT755274)
- hsa-miR-6797-5p (MIRT756183)
- hsa-miR-6804-5p (MIRT756422)
- hsa-miR-6808-5p (MIRT756558)
- hsa-miR-6814-5p (MIRT756755)
- hsa-miR-6825-5p (MIRT756967)
- hsa-miR-6829-5p (MIRT757099)
- hsa-miR-6842-5p (MIRT757357)
- hsa-miR-6847-5p (MIRT757461)
- hsa-miR-6856-5p (MIRT757714)
- hsa-miR-6880-5p (MIRT758299)
- hsa-miR-6893-5p (MIRT758702)
- hsa-miR-6894-5p (MIRT758767)
- hsa-miR-7106-5p (MIRT758843)
- hsa-miR-7110-5p (MIRT758983)
- hsa-miR-7114-5p (MIRT759137)
- hsa-miR-7154-3p (MIRT759215)
- hsa-miR-762 (MIRT759494)
- hsa-miR-765 (MIRT759549)
- hsa-miR-766-5p (MIRT759634)
- hsa-miR-7847-3p (MIRT759833)
- hsa-miR-874-5p (MIRT760335)
- hsa-miR-887-5p (MIRT760404)
- hsa-miR-940 (MIRT760799)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COL1A1
- Browse OriGene Inhibitory RNA Products For COL1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COL1A1
Clone Products
- Applied Biological Materials (abm): Clones for COL1A1 - Select products 50% OFF >
- * COL1A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for COL1A1
- Addgene plasmids for COL1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COL1A1
Cell Line Products
-
Horizon Cell Lines for COL1A1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for COL1A1 Gene
Localization for COL1A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COL1A1 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| cytoskeleton | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytosol | 3 |
| golgi apparatus | 3 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005581 | collagen trimer | IEA | -- |
| GO:0005584 | collagen type I trimer | IBA,IMP | 14976317 |
| GO:0005615 | extracellular space | IEA,IMP | 20603131 |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
Pathways & Interactions for COL1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
Blood Coagulation Cascade
.46
|
|
| 2 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Focal Adhesion |
.61
|
.61
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for COL1A1 Gene
7 BioSystems pathways for COL1A1 Gene
8 Reactome pathways for COL1A1 Gene
1 PharmGKB pathway for COL1A1 Gene
10 KEGG pathways for COL1A1 Gene
8 GeneGo (Thomson Reuters) pathways for COL1A1 Gene
- Cell adhesion Integrin inside-out signaling
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cell adhesion_ECM remodeling
- Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
- Cytoskeleton remodeling Integrin outside-in signaling
15 Qiagen pathways for COL1A1 Gene
- Blood Coagulation Cascade
- ERK Signaling
- FAK1 Signaling
- GnRH Signaling
- ILK Signaling
1 Cell Signaling Technology pathway for COL1A1 Gene
Interacting Proteins for COL1A1 Gene
Selected Interacting proteins:
P02452-CO1A1_HUMAN
ENSP00000225964
for COL1A1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for COL1A1
SIGNOR curated interactions for COL1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA,IMP | 1874719 |
| GO:0001503 | ossification | IEA,IBA | 21873635 |
| GO:0001568 | blood vessel development | IBA,IMP | 17211858 |
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0001957 | intramembranous ossification | IEA | -- |
Drugs & Compounds for COL1A1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Collagenase | Approved, Investigational | Pharma | Target | 0 | ||
| Von Willebrand Factor Human | Approved, Investigational | Pharma | Target, binder | 0 | ||
| Vonicog Alfa | Approved, Investigational | Pharma | Target, binder | 0 | ||
| Clove oil | Approved | Nutra | Target | 0 | ||
| Somatotropin | Approved, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- SouthernBiotech Human Type I Collagen-Solution
Transcripts for COL1A1 Gene
mRNA/cDNA for COL1A1 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000225964 5914 nts (view in UCSC)
- ENST00000510710 1147 nts (view in UCSC)
- ENST00000486572 836 nts (view in UCSC)
- ENST00000511732 789 nts (view in UCSC)
- ENST00000494334 396 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for COL1A1 - Select products 50% OFF >
- * COL1A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for COL1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COL1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for COL1A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COL1A1
- Browse OriGene Inhibitory RNA Products For COL1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COL1A1
Clone Products
- Applied Biological Materials (abm): Clones for COL1A1 - Select products 50% OFF >
- * COL1A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for COL1A1
- Addgene plasmids for COL1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COL1A1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 42 | ^ | 43 | ^ | 44 | ^ | 45a | · | 45b | ^ | 46a | · | 46b | ^ | 47 | ^ | 48a | · | 48b | ^ | 49a | · | 49b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||
| SP12: |
Relevant External Links for COL1A1 Gene
- GeneLoc Exon Structure for
- COL1A1
Expression for COL1A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Fusing Suture Cells Rostral Sutures
- Immature Endochondral Osteoblasts Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Immature Endochondral Osteoblasts Stylopod Periosteum
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Central Intermediate Lamina Cells Autopod Synovial Joint
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
-
Limb (Muscoskeletal System)
- Central Intermediate Lamina Cells Autopod Synovial Joint
- Central Intermediate Lamina Cells Zeugopod Synovial Joint
- Prechondrocytic Mesenchymal Cells Stylopod
- Prechondrocytic Mesenchymal Cells Zeugopod
- Mesenchymal Condensate Cells Stylopod
-
Tooth (Integumentary System)
- Cementoblasts Cementum
- Cementocytes Cementum
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Odontoblasts Dentin
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Condensate Cells Dermal Papilla
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Mature Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
-
Tendon & Ligament (Muscoskeletal System)
- Tenocytes Limb Tendons and Ligaments
- Early Tenocyte Cells Axial Tendon Primordia
- Tenocytes Axial Tendons and Ligamnets
- Early Tenocyte Cells Limb Tendon Primordia
- Tenocytes
- Mesenchymal Stem Cells
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Mature Cardiac Fibroblasts Myocardium
- Subepicardial Cells Epicardium
- Cardiac stem cells
- Umbilical Cord (Extraembryonic Tissues)
- Neural Crest (Gastrulation Derivatives)
- NULL (Uncategorized)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
-
Epithelial Cells
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Eye (Sensory Organs)