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Aliases for COG7 Gene

Aliases for COG7 Gene

  • Component Of Oligomeric Golgi Complex 7 2 3 4 5
  • COG Complex Subunit 7 3 4
  • Conserved Oligomeric Golgi Complex Subunit 7 3
  • CDG2E 3

External Ids for COG7 Gene

Previous GeneCards Identifiers for COG7 Gene

  • GC16M022808
  • GC16M023487
  • GC16M023327
  • GC16M023366
  • GC16M021487

Summaries for COG7 Gene

Entrez Gene Summary for COG7 Gene

  • The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

GeneCards Summary for COG7 Gene

COG7 (Component Of Oligomeric Golgi Complex 7) is a Protein Coding gene. Diseases associated with COG7 include Congenital Disorder Of Glycosylation, Type Ii and Congenital Disorder Of Glycosylation, Type In. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins.

UniProtKB/Swiss-Prot for COG7 Gene

  • Required for normal Golgi function.

Gene Wiki entry for COG7 Gene

Additional gene information for COG7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG7 Gene

Genomics for COG7 Gene

GeneHancer (GH) Regulatory Elements for COG7 Gene

Promoters and enhancers for COG7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J023452 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 650.7 +0.3 309 1.8 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 E2F8 ZNF143 ENSG00000260136 COG7 PALB2 NPIPB5 ENSG00000261723 DCTN5 SCNN1B ENSG00000260751 GGA2 ENSG00000260905
GH16J023141 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 13.7 +307.5 307469 8.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SMG1P1 ENSG00000260635 ENSG00000260751 USP31 NPIPB5 COG7 PALB2 POLR3E SCNN1G ENSG00000260905
GH16J023508 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 -56.6 -56602 2.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A GGA2 PALB2 ENSG00000260905 DCTN5 LOC100419017 ENSG00000260751 COG7 NDUFAB1 UBFD1 PIR42085
GH16J023503 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -52.4 -52406 4 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 IRF4 ZNF766 ZNF213 FOS DCTN5 COG7 UBFD1 GGA2 PRKCB LOC100419017 PIR42085
GH16J023496 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -44.1 -44093 2 HDAC1 TEAD4 MAX YY1 FOSL1 MTA3 FOXK2 EGR1 ADNP VEZF1 COG7 PALB2 ENSG00000260751 ENSG00000260905 UBFD1 GGA2 LOC100419017 GC16M023463
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COG7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COG7 gene promoter:
  • STAT5B
  • Arnt
  • AhR
  • AML1a
  • p53
  • Egr-3
  • SEF-1 (1)
  • deltaCREB
  • CREB
  • GCNF

Genomic Locations for COG7 Gene

Genomic Locations for COG7 Gene
64,718 bases
Minus strand
64,699 bases
Minus strand

Genomic View for COG7 Gene

Genes around COG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG7 Gene

Proteins for COG7 Gene

  • Protein details for COG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 7
    Protein Accession:
    Secondary Accessions:
    • Q6UWU7

    Protein attributes for COG7 Gene

    770 amino acids
    Molecular mass:
    86344 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
    • Sequence=AAQ88995.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COG7 Gene

Post-translational modifications for COG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COG7 Gene

No data available for DME Specific Peptides for COG7 Gene

Domains & Families for COG7 Gene

Gene Families for COG7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for COG7 Gene


Suggested Antigen Peptide Sequences for COG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COG7 family.
  • Belongs to the COG7 family.
genes like me logo Genes that share domains with COG7: view

Function for COG7 Gene

Molecular function for COG7 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi function.

Phenotypes From GWAS Catalog for COG7 Gene

Gene Ontology (GO) - Molecular Function for COG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15047703
genes like me logo Genes that share ontologies with COG7: view
genes like me logo Genes that share phenotypes with COG7: view

Human Phenotype Ontology for COG7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for COG7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for COG7 Gene

Localization for COG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG7 Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COG7 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA,IEA 11980916
GO:0016020 membrane IEA --
GO:0017119 Golgi transport complex IDA,IEA 15047703
genes like me logo Genes that share ontologies with COG7: view

Pathways & Interactions for COG7 Gene

genes like me logo Genes that share pathways with COG7: view

Gene Ontology (GO) - Biological Process for COG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IMP 15107842
GO:0006886 intracellular protein transport IMP,IEA 15107842
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 16420527
GO:0007030 Golgi organization IBA --
genes like me logo Genes that share ontologies with COG7: view

No data available for SIGNOR curated interactions for COG7 Gene

Drugs & Compounds for COG7 Gene

No Compound Related Data Available

Transcripts for COG7 Gene

mRNA/cDNA for COG7 Gene

Unigene Clusters for COG7 Gene

Component of oligomeric golgi complex 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COG7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP3: - -
SP4: -
SP5: -

ExUns: 18b

Relevant External Links for COG7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COG7 Gene

Protein differential expression in normal tissues from HIPED for COG7 Gene

This gene is overexpressed in Bone (51.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COG7 Gene

Protein tissue co-expression partners for COG7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COG7 Gene:


SOURCE GeneReport for Unigene cluster for COG7 Gene:


Evidence on tissue expression from TISSUES for COG7 Gene

  • Nervous system(4.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for COG7 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • immune
  • lymphatic
  • nervous
  • skeletal muscle
Head and neck:
  • ear
  • heart
  • heart valve
genes like me logo Genes that share expression patterns with COG7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COG7 Gene

Orthologs for COG7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COG7 34 33
  • 99.48 (n)
(Canis familiaris)
Mammalia COG7 34 33
  • 89.65 (n)
(Bos Taurus)
Mammalia COG7 34 33
  • 89.13 (n)
(Mus musculus)
Mammalia Cog7 16 34 33
  • 88.05 (n)
(Monodelphis domestica)
Mammalia COG7 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Cog7 33
  • 86.71 (n)
(Ornithorhynchus anatinus)
Mammalia COG7 34
  • 85 (a)
(Gallus gallus)
Aves COG7 34 33
  • 74.71 (n)
(Anolis carolinensis)
Reptilia COG7 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog7 33
  • 71.27 (n)
Str.16611 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33970 33
(Danio rerio)
Actinopterygii cog7 34 33
  • 66.88 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1624 33
fruit fly
(Drosophila melanogaster)
Insecta Cog7 34 33
  • 43.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004439 33
  • 42.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EYE 33
  • 42.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for COG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COG7 Gene

Gene Tree for COG7 (if available)
Gene Tree for COG7 (if available)
Evolutionary constrained regions (ECRs) for COG7: view image

Paralogs for COG7 Gene

No data available for Paralogs for COG7 Gene

Variants for COG7 Gene

Sequence variations from dbSNP and Humsavar for COG7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs112011340 uncertain-significance, Congenital disorder of glycosylation 23,388,937(-) G/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs112611398 uncertain-significance, likely-benign, Congenital disorder of glycosylation, not specified 23,424,858(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs114458562 uncertain-significance, likely-benign, Congenital disorder of glycosylation, not specified 23,393,264(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs116153163 uncertain-significance, Congenital disorder of glycosylation 23,410,315(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs116331296 uncertain-significance, Congenital disorder of glycosylation 23,417,081(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for COG7 Gene

Variant ID Type Subtype PubMed ID
dgv2826n100 CNV gain 25217958
nsv1066078 CNV gain 25217958
nsv1127477 CNV deletion 24896259
nsv1134509 CNV deletion 24896259
nsv1768 CNV insertion 18451855
nsv475746 CNV novel sequence insertion 20440878

Variation tolerance for COG7 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COG7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG7 Gene

Disorders for COG7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for COG7 Gene - From: HGMD, OMIM, ClinVar, Orphanet, and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search COG7 in MalaCards View complete list of genes associated with diseases


  • Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:15107842}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for COG7

genes like me logo Genes that share disorders with COG7: view

No data available for Genatlas for COG7 Gene

Publications for COG7 Gene

  1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D … Waters MG (The Journal of cell biology 2002) 2 3 4 58
  2. A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. (PMID: 17356545) Morava E … Wevers RA (European journal of human genetics : EJHG 2007) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. (PMID: 15107842) Wu X … Freeze HH (Nature medicine 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for COG7 Gene

Sources for COG7 Gene

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