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Aliases for COG3 Gene

Aliases for COG3 Gene

  • Component Of Oligomeric Golgi Complex 3 2 3 4 5
  • Vesicle-Docking Protein SEC34 Homolog 3 4
  • COG Complex Subunit 3 3 4
  • SEC34 3 4
  • P94 3 4
  • Conserved Oligomeric Golgi Complex Subunit 3 3
  • Tethering Factor SEC34 3

External Ids for COG3 Gene

Previous GeneCards Identifiers for COG3 Gene

  • GC13P044039
  • GC13P040026
  • GC13P044975
  • GC13P043837
  • GC13P044937
  • GC13P046039
  • GC13P026835

Summaries for COG3 Gene

Entrez Gene Summary for COG3 Gene

  • This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]

GeneCards Summary for COG3 Gene

COG3 (Component Of Oligomeric Golgi Complex 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for COG3 Gene

  • Involved in ER-Golgi transport.

Gene Wiki entry for COG3 Gene

Additional gene information for COG3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG3 Gene

Genomics for COG3 Gene

GeneHancer (GH) Regulatory Elements for COG3 Gene

Promoters and enhancers for COG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J045463 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 662.4 +0.2 224 2.9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B E2F8 COG3 RN7SL49P TPT1-AS1 GPALPP1 GC13M045553
GH13J045338 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.1 -124.1 -124125 4.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TPT1-AS1 ENSG00000273149 TPT1 GC13M045344 GC13M045343 COG3 SLC25A30 PPIAP25 LOC105370188 ENSG00000225727
GH13J044712 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 55.7 -750.5 -750462 3.8 ZFP64 ZNF213 RCOR1 FOS ZNF202 ZNF680 RXRA ZC3H11A CEBPB REST TSC22D1 COG3 GPALPP1 ERICH6B RN7SL49P TPT1-AS1 RCN1P2 SMARCE1P5 CCDC122 KCTD4
GH13J044571 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 28.7 -889.2 -889194 8.2 HDGF ZFP64 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 YY1 ZNF766 TSC22D1 TSC22D1-AS1 GC13P044576 COG3 SMARCE1P5 ENSG00000225727
GH13J046372 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.6 +917.3 917274 18.9 HDGF ATF1 PKNOX1 SMAD1 SIN3A YBX1 IRF4 ZNF48 TCF12 GLIS2 RUBCNL GC13P046380 OR7E101P COG3 LINC01198 LRCH1 LCP1 RNU2-6P GC13M046376 GC13P046411
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COG3 gene promoter:
  • c-Rel
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-4a
  • GCNF-2
  • GCNF-1
  • GCNF

Genomic Locations for COG3 Gene

Genomic Locations for COG3 Gene
71,804 bases
Plus strand
71,804 bases
Plus strand

Genomic View for COG3 Gene

Genes around COG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG3 Gene

Proteins for COG3 Gene

  • Protein details for COG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 3
    Protein Accession:
    Secondary Accessions:
    • B2RAW5
    • Q5VT70
    • Q8IXX4
    • Q9BZ92

    Protein attributes for COG3 Gene

    828 amino acids
    Molecular mass:
    94096 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115.

    Alternative splice isoforms for COG3 Gene


neXtProt entry for COG3 Gene

Post-translational modifications for COG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COG3 Gene

No data available for DME Specific Peptides for COG3 Gene

Domains & Families for COG3 Gene

Gene Families for COG3 Gene

Protein Domains for COG3 Gene


Suggested Antigen Peptide Sequences for COG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COG3 family.
  • Belongs to the COG3 family.
genes like me logo Genes that share domains with COG3: view

Function for COG3 Gene

Molecular function for COG3 Gene

UniProtKB/Swiss-Prot Function:
Involved in ER-Golgi transport.

Phenotypes From GWAS Catalog for COG3 Gene

Gene Ontology (GO) - Molecular Function for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19536132
GO:0008565 protein transporter activity IDA 11929878
genes like me logo Genes that share ontologies with COG3: view
genes like me logo Genes that share phenotypes with COG3: view

Animal Models for COG3 Gene

MGI Knock Outs for COG3:
  • Cog3 Cog3<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for COG3 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COG3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COG3 Gene

Localization for COG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG3 Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the peripheral membrane of cis/medial cisternae.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COG3 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Cytosol (3)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA,IEA 11980916
GO:0005801 cis-Golgi network IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with COG3: view

Pathways & Interactions for COG3 Gene

genes like me logo Genes that share pathways with COG3: view

Gene Ontology (GO) - Biological Process for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IMP 16420527
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 16420527
GO:0006891 intra-Golgi vesicle-mediated transport IDA 11929878
genes like me logo Genes that share ontologies with COG3: view

No data available for SIGNOR curated interactions for COG3 Gene

Drugs & Compounds for COG3 Gene

No Compound Related Data Available

Transcripts for COG3 Gene

mRNA/cDNA for COG3 Gene

Unigene Clusters for COG3 Gene

Component of oligomeric golgi complex 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COG3

Alternative Splicing Database (ASD) splice patterns (SP) for COG3 Gene

No ASD Table

Relevant External Links for COG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COG3 Gene

Protein differential expression in normal tissues from HIPED for COG3 Gene

This gene is overexpressed in Bone (59.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COG3 Gene

Protein tissue co-expression partners for COG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COG3 Gene:


SOURCE GeneReport for Unigene cluster for COG3 Gene:


mRNA Expression by UniProt/SwissProt for COG3 Gene:

Tissue specificity: Widely expressed with highest levels in pancreas and testis and lowest levels in lung.

Evidence on tissue expression from TISSUES for COG3 Gene

  • Nervous system(4.7)
  • Blood(4.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with COG3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COG3 Gene

Orthologs for COG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COG3 34 33
  • 99.52 (n)
(Canis familiaris)
Mammalia COG3 34 33
  • 93 (n)
(Bos Taurus)
Mammalia COG3 34 33
  • 92.07 (n)
(Monodelphis domestica)
Mammalia COG3 34
  • 92 (a)
(Mus musculus)
Mammalia Cog3 16 34 33
  • 90.04 (n)
(Rattus norvegicus)
Mammalia Cog3 33
  • 89.91 (n)
(Ornithorhynchus anatinus)
Mammalia COG3 34
  • 89 (a)
(Gallus gallus)
Aves COG3 34 33
  • 81.22 (n)
(Anolis carolinensis)
Reptilia COG3 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog3 33
  • 76.92 (n)
Str.1471 33
(Danio rerio)
Actinopterygii cog3 34 34 33
  • 70.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003970 33
  • 51.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cog3 34 33
  • 51.07 (n)
CG3248 35
  • 42 (a)
(Caenorhabditis elegans)
Secernentea cogc-3 34 33
  • 48.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COG3 36 34
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73430 33
  • 48.57 (n)
(Oryza sativa)
Liliopsida Os08g0451000 33
  • 48.57 (n)
Os.24582 33
sea squirt
(Ciona savignyi)
Ascidiacea Cin.12103 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12103 33
Species where no ortholog for COG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG3 Gene

Gene Tree for COG3 (if available)
Gene Tree for COG3 (if available)
Evolutionary constrained regions (ECRs) for COG3: view image

Paralogs for COG3 Gene

No data available for Paralogs for COG3 Gene

Variants for COG3 Gene

Sequence variations from dbSNP and Humsavar for COG3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs747042102 A breast cancer sample 45,516,191(+) C/G/T 3_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000013095 -- 45,463,619(+) T/C upstream_transcript_variant
rs1000070327 -- 45,463,250(+) C/A upstream_transcript_variant
rs1000070983 -- 45,510,453(+) A/G intron_variant
rs1000268680 -- 45,483,795(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COG3 Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073
esv1140090 CNV deletion 17803354
esv1166784 CNV deletion 17803354
esv3307655 CNV mobile element insertion 20981092
esv3343614 CNV insertion 20981092
nsv1145662 CNV deletion 24896259
nsv455875 CNV loss 19166990
nsv510583 CNV deletion 20534489
nsv561578 CNV loss 21841781

Variation tolerance for COG3 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG3 Gene

Disorders for COG3 Gene

Additional Disease Information for COG3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COG3 Gene

Publications for COG3 Gene

  1. TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. (PMID: 24806965) Ong YS … Hong W (Journal of cell science 2014) 3 4 58
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D … Waters MG (The Journal of cell biology 2002) 2 3 58

Products for COG3 Gene

Sources for COG3 Gene

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