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Aliases for COG2 Gene

Aliases for COG2 Gene

  • Component Of Oligomeric Golgi Complex 2 2 3 4 5
  • Low Density Lipoprotein Receptor Defect C-Complementing Protein 3 4
  • Low Density Lipoprotein Receptor Defect C Complementing 2 3
  • COG Complex Subunit 2 3 4
  • LDLC 3 4
  • Brefeldin A-Sensitive, Peripheral Golgi Protein 3
  • Conserved Oligomeric Golgi Complex Protein 2 3
  • Conserved Oligomeric Golgi Complex Subunit 2 3
  • CDG2Q 3

External Ids for COG2 Gene

Previous HGNC Symbols for COG2 Gene

  • LDLC

Previous GeneCards Identifiers for COG2 Gene

  • GC01P229255
  • GC01P226506
  • GC01P227251
  • GC01P227813
  • GC01P227084
  • GC01P228844
  • GC01P230778
  • GC01P201264

Summaries for COG2 Gene

Entrez Gene Summary for COG2 Gene

  • This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for COG2 Gene

COG2 (Component Of Oligomeric Golgi Complex 2) is a Protein Coding gene. Diseases associated with COG2 include Congenital Disorder Of Glycosylation, Type Iiq and Lipid Metabolism Disorder. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein complex binding and protein transporter activity.

UniProtKB/Swiss-Prot for COG2 Gene

  • Required for normal Golgi morphology and function.

Gene Wiki entry for COG2 Gene

Additional gene information for COG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG2 Gene

Genomics for COG2 Gene

GeneHancer (GH) Regulatory Elements for COG2 Gene

Promoters and enhancers for COG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I230641 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.0 980 3.2 HDGF SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B COG2 C1orf198 LOC101927604 AGT GC01P230645
GH01I231037 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.6 +397.0 397045 4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 KLF13 SP3 FAM89A C1orf131 COG2 ARV1 SPRTN LOC644006
GH01I231418 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 +778.5 778516 5.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF263 SP3 NFYC ZNF610 EGLN1 SPRTN COG2 C1orf131 PIR59803
GH01I231210 Enhancer 1.4 FANTOM5 Ensembl ENCODE 21.3 +569.5 569480 2 ARID4B SIN3A ZNF2 IRF4 ZNF48 GLIS2 ZNF213 ELK1 ARID2 ZNF143 C1orf131 COG2 GNPAT FAM89A LOC644006 MIR1182 LOC101927604 C1orf198 SPRTN LOC149373
GH01I231527 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.8 +886.6 886593 3.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TSNAX ENSG00000233461 TSNAX-DISC1 C1orf131 COG2 DISC1 GNPAT EXOC8 SPRTN GC01P231515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COG2 gene promoter:

Genomic Locations for COG2 Gene

Genomic Locations for COG2 Gene
51,530 bases
Plus strand

Genomic View for COG2 Gene

Genes around COG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG2 Gene

Proteins for COG2 Gene

  • Protein details for COG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q86U99

    Protein attributes for COG2 Gene

    738 amino acids
    Molecular mass:
    83208 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

    Alternative splice isoforms for COG2 Gene


neXtProt entry for COG2 Gene

Post-translational modifications for COG2 Gene

  • Ubiquitination at Lys54, posLast=188188, Lys584, and Lys717
  • Modification sites at PhosphoSitePlus

Other Protein References for COG2 Gene

No data available for DME Specific Peptides for COG2 Gene

Domains & Families for COG2 Gene

Gene Families for COG2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for COG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COG2 family.
  • Belongs to the COG2 family.
genes like me logo Genes that share domains with COG2: view

Function for COG2 Gene

Molecular function for COG2 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi morphology and function.

Phenotypes From GWAS Catalog for COG2 Gene

Gene Ontology (GO) - Molecular Function for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15047703
GO:0008565 protein transporter activity IMP 7962052
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with COG2: view
genes like me logo Genes that share phenotypes with COG2: view

Human Phenotype Ontology for COG2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for COG2 Gene

MGI Knock Outs for COG2:
  • Cog2 tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for COG2 Gene

miRTarBase miRNAs that target COG2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for COG2 Gene

Localization for COG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG2 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COG2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
extracellular 4
nucleus 3
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IDA 7962052
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COG2: view

Pathways & Interactions for COG2 Gene

genes like me logo Genes that share pathways with COG2: view

Gene Ontology (GO) - Biological Process for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006891 intra-Golgi vesicle-mediated transport IMP 7962052
GO:0007030 Golgi organization IMP,IEA 7962052
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with COG2: view

No data available for SIGNOR curated interactions for COG2 Gene

Drugs & Compounds for COG2 Gene

(48) Drugs for COG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(17) Additional Compounds for COG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with COG2: view

Transcripts for COG2 Gene

Unigene Clusters for COG2 Gene

Component of oligomeric golgi complex 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for COG2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - - - -

ExUns: 22

Relevant External Links for COG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COG2 Gene

Protein differential expression in normal tissues from HIPED for COG2 Gene

This gene is overexpressed in Bone (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COG2 Gene

Protein tissue co-expression partners for COG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COG2 Gene:


SOURCE GeneReport for Unigene cluster for COG2 Gene:


Evidence on tissue expression from TISSUES for COG2 Gene

  • Eye(4.2)
  • Nervous system(3.9)
  • Blood(3.6)
  • Liver(3.1)
  • Heart(2.9)
  • Muscle(2.4)
  • Kidney(2.3)
  • Thyroid gland(2.3)
  • Intestine(2)
  • Pancreas(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with COG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COG2 Gene

Orthologs for COG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COG2 33 34
  • 99.5 (n)
(Canis familiaris)
Mammalia cfa-mir-1841 34
  • 91 (a)
COG2 33
  • 89.59 (n)
(Bos Taurus)
Mammalia COG2 33 34
  • 87.13 (n)
(Monodelphis domestica)
Mammalia COG2 34
  • 86 (a)
(Mus musculus)
Mammalia Cog2 33 16 34
  • 81.19 (n)
(Rattus norvegicus)
Mammalia Cog2 33
  • 80.96 (n)
(Ornithorhynchus anatinus)
Mammalia COG2 34
  • 74 (a)
(Gallus gallus)
Aves COG2 33 34
  • 77.66 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 85 (a)
-- 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog2 33
  • 69.21 (n)
Str.11116 33
(Danio rerio)
Actinopterygii cog2 33 34
  • 65.79 (n)
wufj87b02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4936 33
fruit fly
(Drosophila melanogaster)
Insecta ldlCp 35 33 34
  • 45.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003824 33
  • 45.35 (n)
(Caenorhabditis elegans)
Secernentea cogc-2 33 34
  • 39.37 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24840 33
  • 43.55 (n)
(Oryza sativa)
Liliopsida Os03g0849600 33
  • 42.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for COG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG2 Gene

Gene Tree for COG2 (if available)
Gene Tree for COG2 (if available)

Paralogs for COG2 Gene

No data available for Paralogs for COG2 Gene

Variants for COG2 Gene

Sequence variations from dbSNP and Humsavar for COG2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1085307116 pathogenic, CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIq 230,669,462(+) A/AA coding_sequence_variant, stop_gained
rs1085307117 pathogenic, CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIq 230,690,119(+) T/G coding_sequence_variant, missense_variant
rs113173809 benign, CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIq 230,675,112(+) T/C coding_sequence_variant, synonymous_variant
rs6681346 benign, CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIq 230,675,010(+) T/A coding_sequence_variant, missense_variant
VAR_078769 Congenital disorder of glycosylation 2Q (CDG2Q) [MIM:617395] p.Trp634Gly

Structural Variations from Database of Genomic Variants (DGV) for COG2 Gene

Variant ID Type Subtype PubMed ID
esv3444074 CNV insertion 20981092
esv3589093 CNV gain 21293372
nsv472983 CNV novel sequence insertion 20440878
nsv524949 CNV loss 19592680
nsv832836 CNV loss 17160897

Variation tolerance for COG2 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COG2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG2 Gene

Disorders for COG2 Gene

MalaCards: The human disease database

(24) MalaCards diseases for COG2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search COG2 in MalaCards View complete list of genes associated with diseases


  • Congenital disorder of glycosylation 2Q (CDG2Q) [MIM:617395]: A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The transmission pattern of CDG2Q is consistent with autosomal recessive inheritance. {ECO:0000269 PubMed:24784932}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for COG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with COG2: view

No data available for Genatlas for COG2 Gene

Publications for COG2 Gene

  1. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. (PMID: 7962052) Podos SD … Krieger M (The Journal of cell biology 1994) 2 3 4 58
  2. Mutations in COG2 encoding a subunit of the conserved oligomeric golgi complex cause a congenital disorder of glycosylation. (PMID: 24784932) Kodera H … Saitsu H (Clinical genetics 2015) 3 4 58
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  4. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. (PMID: 19105203) Edwards TL … Ritchie MD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58

Products for COG2 Gene

Sources for COG2 Gene

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