Aliases for COBL Gene
External Ids for COBL Gene
Previous GeneCards Identifiers for COBL Gene
This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]
GeneCards Summary for COBL Gene
COBL (Cordon-Bleu WH2 Repeat Protein) is a Protein Coding gene. Diseases associated with COBL include Granulomatosis With Polyangiitis. Gene Ontology (GO) annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is COBLL1.
UniProtKB/Swiss-Prot Summary for COBL Gene
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.