Aliases for COA7 Gene
Aliases for COA7 Gene
External Ids for COA7 Gene
- HGNC: 25716
- Entrez Gene: 65260
- Ensembl: ENSG00000162377
- OMIM: 615623
- UniProtKB: Q96BR5
Previous HGNC Symbols for COA7 Gene
- C1orf163
- SELRC1
Previous GeneCards Identifiers for COA7 Gene
- GC01M053154
Summaries for COA7 Gene
GeneCards Summary for COA7 Gene
COA7 (Cytochrome C Oxidase Assembly Factor 7 (Putative)) is a Protein Coding gene. Diseases associated with COA7 include Mitochondrial Complex Iv Deficiency.
UniProtKB/Swiss-Prot for COA7 Gene
-
Required for assembly of mitochondrial respiratory chain complex I and complex IV.
Additional gene information for COA7 Gene
- Monarch Initiative
- Search for COA7 at DataMed
- Search for COA7 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COA7 Gene
Genomics for COA7 Gene
GeneHancer (GH) Regulatory Elements for COA7 Gene
Promoters and enhancers for COA7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around COA7 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for COA7 Gene
Genomic Locations for COA7 Gene
- chr1:52,684,451-52,698,366
- (GRCh38/hg38)
- Size:
- 13,916 bases
- Orientation:
- Minus strand
- chr1:53,152,014-53,164,038
- (GRCh37/hg19)
Genomic View for COA7 Gene
Genes around COA7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p32.3 by Ensembl
- 1p32.3 by Entrez Gene
- 1p32.3 by HGNC
COA7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COA7 Gene
Proteins for COA7 Gene
-
Protein details for COA7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96BR5-COA7_HUMAN
- Recommended name:
- Cytochrome c oxidase assembly factor 7
- Protein Accession:
- Q96BR5
- Q0P6I7
- Q9H9Z9
Protein attributes for COA7 Gene
- Size:
- 231 amino acids
- Molecular mass:
- 25709 Da
- Quaternary structure:
- No Data Available
Protein Expression for COA7 Gene
Post-translational modifications for COA7 Gene
No Post-translational modifications
Other Protein References for COA7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for COA7
-
Abcam antibodies for COA7
- Invitrogen Antibodies for COA7
- Search GeneTex for Antibodies for COA7
Protein Products
-
OriGene Purified Proteins for COA7
- Search Origene for MassSpec and Protein Over-expression Lysates for COA7
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- Search GeneTex for Proteins for COA7
-
Abcam proteins for COA7
Assay Products
No data available for DME Specific Peptides for COA7 Gene
Domains & Families for COA7 Gene
Gene Families for COA7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for COA7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96BR5- Family:
-
- Belongs to the hcp beta-lactamase family.
Function for COA7 Gene
Molecular function for COA7 Gene
- UniProtKB/Swiss-Prot Function:
- Required for assembly of mitochondrial respiratory chain complex I and complex IV.
Phenotypes for COA7 Gene
- GenomeRNAi human phenotypes for COA7:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for COA7
-
-
ViGene Biosciences lentiviral particle packaged cDNA for COA7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for COA7 gene
- Search ViGene Biosciences for COA7
CRISPR Products
-
OriGene CRISPR knockouts for COA7
- genomics-online: gRNA clones - Search results for available C1orf163 gene related products
- Applied Biological Materials CRISPR for COA7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COA7
miRNA for COA7 Gene
- miRTarBase miRNAs that target COA7
-
- hsa-mir-16-5p (MIRT031377)
- hsa-mir-615-3p (MIRT039855)
- hsa-mir-92a-3p (MIRT049077)
- hsa-mir-129-5p (MIRT783469)
- hsa-mir-147a (MIRT783848)
- hsa-mir-2113 (MIRT784207)
- hsa-mir-3672 (MIRT785123)
- hsa-mir-4328 (MIRT785768)
- hsa-mir-4455 (MIRT785913)
- hsa-mir-4524a-3p (MIRT786104)
- hsa-mir-5010-3p (MIRT786984)
- hsa-mir-574-5p (MIRT787850)
- hsa-mir-6818-5p (MIRT788929)
- hsa-mir-6864-3p (MIRT789128)
- hsa-mir-6867-5p (MIRT789189)
- hsa-mir-8055 (MIRT789661)
miRNA Products
- Search ViGene Biosciences for COA7
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for COA7
- Browse OriGene Inhibitory RNA Products For COA7
- genomics-online: shRNA clones - Search results for available C1orf163 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for COA7 gene
Clone Products
- Sino Biological Human cDNA Clone for COA7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COA7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COA7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available C1orf163 gene related products
- orf clones - Search results for available C1orf163 gene related products
- Applied Biological Materials Clones for COA7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for COA7
-
ViGene Biosciences adenoviral particle packaged cDNA for COA7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for COA7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for COA7 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for COA7 Gene
Localization for COA7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COA7 Gene
- Mitochondrion intermembrane space.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| extracellular | 2 |
| cytosol | 2 |
- Mitochondria (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005739 | mitochondrion | IDA,IEA | -- |
| GO:0005758 | mitochondrial intermembrane space | IEA | -- |
Pathways & Interactions for COA7 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for COA7 Gene
Transcripts for COA7 Gene
mRNA/cDNA for COA7 Gene
- (1) REFSEQ mRNAs :
- (85) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for COA7
- genomics-online: gRNA clones - Search results for available C1orf163 gene related products
- Applied Biological Materials CRISPR for COA7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COA7
miRNA Products
- Search ViGene Biosciences for COA7
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for COA7
- Browse OriGene Inhibitory RNA Products For COA7
- genomics-online: shRNA clones - Search results for available C1orf163 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for COA7 gene
Clone Products
- Sino Biological Human cDNA Clone for COA7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COA7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COA7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available C1orf163 gene related products
- orf clones - Search results for available C1orf163 gene related products
- Applied Biological Materials Clones for COA7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: |
Expression for COA7 Gene
This gene is overexpressed in Serum (64.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COA7 Gene
NURSA nuclear receptor signaling pathways regulating expression of COA7 Gene:
COA7Evidence on tissue expression from TISSUES for COA7 Gene
- Bone marrow(4.1)
Primer Products
-
OriGene qPCR primer pairs for COA7
-
OriGene qPCR primer pairs and template standards for COA7
- genomics-online: primer clones - Search results for available C1orf163 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COA7 Gene
Orthologs for COA7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SELRC1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | COA7 34 |
|
OneToOne | |
| SELRC1 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | COA7 34 |
|
OneToOne | |
| SELRC1 33 |
|
||||
| mouse (Mus musculus) |
Mammalia | Selrc1 34 |
|
OneToOne | |
| Coa7 33 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Selrc1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | COA7 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | COA7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SELRC1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | COA7 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | coa7 33 |
|
||
| Str.15655 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3290 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | coa7 33 |
|
||
| selrc1 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG13865 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ZK20.4 33 34 |
|
- Species where no ortholog for COA7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for COA7 Gene
No data available for Paralogs for COA7 Gene
Variants for COA7 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs961876891 | pathogenic, Cytochrome-c oxidase deficiency | 52,688,006(-) | T/C | coding_sequence_variant, missense_variant | |
| rs1000003548 | -- | 52,693,686(-) | C/T | intron_variant | |
| rs1000054882 | -- | 52,694,180(-) | T/C/G | intron_variant | |
| rs1000241546 | -- | 52,687,410(-) | C/G | 3_prime_UTR_variant | |
| rs1000593398 | -- | 52,687,826(-) | C/T | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1001535 | CNV | gain | 25217958 |
| esv2758934 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.78;
83.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for COA7 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COA7 Gene
Disorders for COA7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mitochondrial complex iv deficiency |
|
Search COA7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for COA7
No data available for UniProtKB/Swiss-Prot and Genatlas for COA7 Gene
Publications for COA7 Gene
- C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly. (PMID: 24333015) Kozjak-Pavlovic V … Rudel T (Journal of molecular biology 2014) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
Products for COA7 Gene
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- Invitrogen Antibodies for COA7
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- VectorBuilder custom plasmid, inducible vectors for COA7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COA7
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for COA7
- Search GeneTex for Proteins for COA7
- ViGene Biosciences adenoviral particle packaged cDNA for COA7 gene
- ViGene Biosciences lentiviral particle packaged cDNA for COA7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for COA7 gene
- Search ViGene Biosciences for COA7
- Horizon Cell Lines for COA7
- genomics-online: cdna clones - Search results for available C1orf163 gene related products
- orf clones - Search results for available C1orf163 gene related products
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- genomics-online: primer clones - Search results for available C1orf163 gene related products
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Sources for COA7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
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- (133) ENCODE
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- (135) Horizon
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- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew