Aliases for COA3 Gene
External Ids for COA3 Gene
Previous HGNC Symbols for COA3 Gene
Previous GeneCards Identifiers for COA3 Gene
This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]
GeneCards Summary for COA3 Gene
COA3 (Cytochrome C Oxidase Assembly Factor 3) is a Protein Coding gene. Diseases associated with COA3 include Mitochondrial Complex Iv Deficiency and Amelogenesis Imperfecta, Type Iv. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..
UniProtKB/Swiss-Prot Summary for COA3 Gene
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.