This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] See more...

Aliases for CNTROB Gene

Aliases for CNTROB Gene

  • Centrobin, Centriole Duplication And Spindle Assembly Protein 2 3 5
  • Centrobin 2 3 4
  • LIP8 2 3 4
  • Centrobin, Centrosomal BRCA2 Interacting Protein 2 3
  • Centrosomal BRCA2-Interacting Protein 3 4
  • LYST-Interacting Protein 8 3 4
  • PP1221 2 3
  • LYST-Interacting Protein LIP8 3
  • CNTROB 5

External Ids for CNTROB Gene

Previous GeneCards Identifiers for CNTROB Gene

  • GC17P007777
  • GC17P007835

Summaries for CNTROB Gene

Entrez Gene Summary for CNTROB Gene

  • This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CNTROB Gene

CNTROB (Centrobin, Centriole Duplication And Spindle Assembly Protein) is a Protein Coding gene. Diseases associated with CNTROB include Squamous Cell Papilloma and Isolated Growth Hormone Deficiency, Type Ia. Gene Ontology (GO) annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot Summary for CNTROB Gene

  • Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Gene Wiki entry for CNTROB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNTROB Gene

Genomics for CNTROB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CNTROB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNTROB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNTROB

Top Transcription factor binding sites by QIAGEN in the CNTROB gene promoter:
  • Elk-1
  • GATA-2
  • Ik-1
  • NCX
  • NF-kappaB
  • NF-kappaB1
  • Pbx1a
  • Sp1
  • SREBP-1a
  • ZID

Genomic Locations for CNTROB Gene

Genomic Locations for CNTROB Gene
chr17:7,932,054-7,949,920
(GRCh38/hg38)
Size:
17,867 bases
Orientation:
Plus strand
chr17:7,835,419-7,853,236
(GRCh37/hg19)
Size:
17,818 bases
Orientation:
Plus strand

Genomic View for CNTROB Gene

Genes around CNTROB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTROB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTROB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTROB Gene

Proteins for CNTROB Gene

  • Protein details for CNTROB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N137-CNTRB_HUMAN
    Recommended name:
    Centrobin
    Protein Accession:
    Q8N137
    Secondary Accessions:
    • A6NHQ1
    • Q331K3
    • Q69YV7
    • Q8NCB8
    • Q8WXV3
    • Q96CQ7
    • Q9C060

    Protein attributes for CNTROB Gene

    Size:
    903 amino acids
    Molecular mass:
    101253 Da
    Quaternary structure:
    • Interacts with LYST.
    SequenceCaution:
    • Sequence=AAG49447.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAG49447.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAC11241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNTROB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTROB Gene

Post-translational modifications for CNTROB Gene

  • Ubiquitination at Lys610, Lys761, and Lys832
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNTROB Gene

Domains & Families for CNTROB Gene

Gene Families for CNTROB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNTROB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNTROB Gene

GenScript: Design optimal peptide antigens:
  • LYST-interacting protein 8 (CNTRB_HUMAN)
genes like me logo Genes that share domains with CNTROB: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CNTROB Gene

Function for CNTROB Gene

Molecular function for CNTROB Gene

UniProtKB/Swiss-Prot Function:
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Phenotypes From GWAS Catalog for CNTROB Gene

Gene Ontology (GO) - Molecular Function for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275750
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with CNTROB: view
genes like me logo Genes that share phenotypes with CNTROB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNTROB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTROB Gene

Localization for CNTROB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTROB Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNTROB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IMP 21576394
GO:0005814 centriole IBA,IDA 16275750
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CNTROB: view

Pathways & Interactions for CNTROB Gene

PathCards logo

SuperPathways for CNTROB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007099 centriole replication IEA,IMP 16275750
GO:0051299 centrosome separation IBA,IMP 16275750
GO:0051301 cell division IEA --
GO:1902017 regulation of cilium assembly IEA --
genes like me logo Genes that share ontologies with CNTROB: view

No data available for Pathways by source and SIGNOR curated interactions for CNTROB Gene

Drugs & Compounds for CNTROB Gene

No Compound Related Data Available

Transcripts for CNTROB Gene

mRNA/cDNA for CNTROB Gene

11 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNTROB

Alternative Splicing Database (ASD) splice patterns (SP) for CNTROB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: -
SP2: -
SP3: -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CNTROB Gene

GeneLoc Exon Structure for
CNTROB

Expression for CNTROB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNTROB Gene

Protein differential expression in normal tissues from HIPED for CNTROB Gene

This gene is overexpressed in Bone marrow stromal cell (30.8) and Fetal testis (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNTROB Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNTROB

SOURCE GeneReport for Unigene cluster for CNTROB Gene:

Hs.348012

mRNA Expression by UniProt/SwissProt for CNTROB Gene:

Q8N137-CNTRB_HUMAN
Tissue specificity: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CNTROB Gene

  • Skin(4.5)
  • Nervous system(4.4)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with CNTROB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNTROB Gene

Orthologs for CNTROB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTROB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CNTROB 30 31
  • 99.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cntrob 30
  • 84.69 (n)
Mouse
(Mus musculus)
Mammalia Cntrob 30 17 31
  • 84.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CNTROB 30 31
  • 84.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CNTROB 31
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CNTROB 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CNTROB 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CNTROB 31
  • 44 (a)
OneToOne
Species where no ortholog for CNTROB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CNTROB Gene

ENSEMBL:
Gene Tree for CNTROB (if available)
TreeFam:
Gene Tree for CNTROB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNTROB: view image

Paralogs for CNTROB Gene

No data available for Paralogs for CNTROB Gene

Variants for CNTROB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNTROB Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs11650083 - p.Pro578Gln
rs35421969 - p.Arg439Gln

Additional dbSNP identifiers (rs#s) for CNTROB Gene

Structural Variations from Database of Genomic Variants (DGV) for CNTROB Gene

Variant ID Type Subtype PubMed ID
esv2670156 CNV deletion 23128226
nsv457660 CNV loss 19166990
nsv574333 CNV loss 21841781

Variation tolerance for CNTROB Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNTROB Gene

Human Gene Mutation Database (HGMD)
CNTROB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNTROB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTROB Gene

Disorders for CNTROB Gene

MalaCards: The human disease database

(3) MalaCards diseases for CNTROB Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CNTROB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CNTROB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTROB Gene

Publications for CNTROB Gene

  1. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. (PMID: 16275750) Zou C … Gao Q (The Journal of cell biology 2005) 2 3 4 23
  2. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev VT … Kingsmore SF (Molecular medicine (Cambridge, Mass.) 2002) 2 3 4
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
  4. Centrobin regulates the assembly of functional mitotic spindles. (PMID: 20190801) Jeffery JM … Khanna KK (Oncogene 2010) 3 23
  5. Inhibition of centriole duplication by centrobin depletion leads to p38-p53 mediated cell-cycle arrest. (PMID: 20085806) Song L … Li J (Cellular signalling 2010) 3 23

Products for CNTROB Gene

  • Signalway Proteins for CNTROB

Sources for CNTROB Gene