Aliases for CNTRL Gene
External Ids for CNTRL Gene
Previous HGNC Symbols for CNTRL Gene
Previous GeneCards Identifiers for CNTRL Gene
This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for CNTRL Gene
CNTRL (Centriolin) is a Protein Coding gene. Diseases associated with CNTRL include 8P11 Myeloproliferative Syndrome and Joubert Syndrome 1. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include nucleotide binding.
UniProtKB/Swiss-Prot Summary for CNTRL Gene
Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.