Aliases for CNTN6 Gene
External Ids for CNTN6 Gene
Previous GeneCards Identifiers for CNTN6 Gene
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for CNTN6 Gene
CNTN6 (Contactin 6) is a Protein Coding gene. Diseases associated with CNTN6 include Chromosome 3Pter-P25 Deletion Syndrome and Coffin-Siris Syndrome 6. Among its related pathways are Notch Signaling Pathway (WikiPathways) and L1CAM interactions. An important paralog of this gene is CNTN4.
UniProtKB/Swiss-Prot Summary for CNTN6 Gene
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).