Aliases for CNTFR Gene
External Ids for CNTFR Gene
Previous GeneCards Identifiers for CNTFR Gene
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for CNTFR Gene
CNTFR (Ciliary Neurotrophic Factor Receptor) is a Protein Coding gene. Diseases associated with CNTFR include Cold-Induced Sweating Syndrome and Crisponi/Cold-Induced Sweating Syndrome 1. Among its related pathways are Interleukin-6 family signaling and CNTF Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and ciliary neurotrophic factor receptor activity. An important paralog of this gene is IL11RA.
UniProtKB/Swiss-Prot Summary for CNTFR Gene
Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303).