External Ids for CNTF Gene
Previous GeneCards Identifiers for CNTF Gene
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
GeneCards Summary for CNTF Gene
CNTF (Ciliary Neurotrophic Factor) is a Protein Coding gene. Diseases associated with CNTF include Motor Neuron Disease and Epilepsy, Familial Temporal Lobe, 2. Among its related pathways are Cytokine Signaling in Immune system and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and ciliary neurotrophic factor receptor binding.
UniProtKB/Swiss-Prot Summary for CNTF Gene
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.