External Ids for CNTF Gene
Previous GeneCards Identifiers for CNTF Gene
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
GeneCards Summary for CNTF Gene
CNTF (Ciliary Neurotrophic Factor) is a Protein Coding gene. Diseases associated with CNTF include Motor Neuron Disease and Amyotrophic Lateral Sclerosis 19. Among its related pathways are Interleukin-6 family signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include growth factor activity and ciliary neurotrophic factor receptor binding.
UniProtKB/Swiss-Prot for CNTF Gene
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.