Aliases for CNTD2 Gene

Aliases for CNTD2 Gene

  • Cyclin N-Terminal Domain Containing 2 2 3 5
  • Cyclin N-Terminal Domain-Containing Protein 2 3 4
  • Cyclin P 2 3
  • CCNP 3

External Ids for CNTD2 Gene

Previous GeneCards Identifiers for CNTD2 Gene

  • GC19M045420
  • GC19M040728
  • GC19M037163

Summaries for CNTD2 Gene

GeneCards Summary for CNTD2 Gene

CNTD2 (Cyclin N-Terminal Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.

Additional gene information for CNTD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNTD2 Gene

Genomics for CNTD2 Gene

GeneHancer (GH) Regulatory Elements for CNTD2 Gene

Promoters and enhancers for CNTD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040225 Promoter/Enhancer 1.2 Ensembl ENCODE 500.7 +0.8 824 1.1 ZNF217 POLR2G ZIC2 ZNF423 ZNF623 CTCF GATAD2B RBM25 ZSCAN9 KMT2B CNTD2 C19orf47 lnc-TTC9B-1
GH19J040226 Enhancer 0.9 ENCODE 500.7 +0.1 146 0.2 ZNF217 POLR2G GATAD2B CTBP1 FOXA2 KMT2B NR2F2 ESRRA KLF9 ELK1 CNTD2 lnc-TTC9B-1
GH19J040228 Enhancer 0.2 Ensembl 500.7 -1.3 -1306 0.4 CNTD2 ENSG00000206925 C19orf47 PLD3 HIPK4 piR-45328
GH19J040190 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.2 +35.6 35594 3 ZNF217 CTCF ZSCAN5C PHF8 JUND SIX5 ZFX ZNF639 ZNF10 ZIC2 MAP3K10 lnc-TTC9B-2 ZNF780B NUMBL CYP2G1P EID2B SUPT5H PAF1 TTC9B CNTD2
GH19J040089 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +136.8 136795 3 EP300 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 POLR2G RBAK GTF2E2 ZNF780A ENSG00000269296 ENSG00000269749 ENSG00000269843 SNRPA FBL ITPKC SUPT5H COQ8B CYP2G1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNTD2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNTD2

Top Transcription factor binding sites by QIAGEN in the CNTD2 gene promoter:
  • GATA-3
  • HOXA5
  • NCX
  • NF-1
  • Pax-4a

Genomic Locations for CNTD2 Gene

Genomic Locations for CNTD2 Gene
chr19:40,222,208-40,227,095
(GRCh38/hg38)
Size:
4,888 bases
Orientation:
Minus strand
chr19:40,728,115-40,732,597
(GRCh37/hg19)
Size:
4,483 bases
Orientation:
Minus strand

Genomic View for CNTD2 Gene

Genes around CNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD2 Gene

Proteins for CNTD2 Gene

  • Protein details for CNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S5-CNTD2_HUMAN
    Recommended name:
    Cyclin N-terminal domain-containing protein 2
    Protein Accession:
    Q9H8S5
    Secondary Accessions:
    • B4DX65

    Protein attributes for CNTD2 Gene

    Size:
    307 amino acids
    Molecular mass:
    33574 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CNTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTD2 Gene

Post-translational modifications for CNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNTD2 Gene

No data available for DME Specific Peptides for CNTD2 Gene

Domains & Families for CNTD2 Gene

Gene Families for CNTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNTD2 Gene

Suggested Antigen Peptide Sequences for CNTD2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50906, weakly similar to G2/mitotic-specific cyclin-B2 (B4DX65_HUMAN)
  • Cyclin N-terminal domain-containing protein 2 (CNTD2_HUMAN)
genes like me logo Genes that share domains with CNTD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CNTD2 Gene

Function for CNTD2 Gene

Gene Ontology (GO) - Molecular Function for CNTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 contributes_to protein kinase activity IBA 21873635
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with CNTD2: view
genes like me logo Genes that share phenotypes with CNTD2: view

miRNA for CNTD2 Gene

miRTarBase miRNAs that target CNTD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTD2 Gene

Localization for CNTD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNTD2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CNTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA 21873635
genes like me logo Genes that share ontologies with CNTD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CNTD2 Gene

Pathways & Interactions for CNTD2 Gene

PathCards logo

SuperPathways for CNTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0044772 mitotic cell cycle phase transition IBA 21873635
genes like me logo Genes that share ontologies with CNTD2: view

No data available for Pathways by source and SIGNOR curated interactions for CNTD2 Gene

Drugs & Compounds for CNTD2 Gene

No Compound Related Data Available

Transcripts for CNTD2 Gene

mRNA/cDNA for CNTD2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for CNTD2 Gene

GeneLoc Exon Structure for
CNTD2

Expression for CNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNTD2 Gene

mRNA differential expression in normal tissues according to GTEx for CNTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7), Brain - Cerebellar Hemisphere (x10.0), Kidney - Cortex (x5.5), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for CNTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNTD2 Gene



Protein tissue co-expression partners for CNTD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNTD2

SOURCE GeneReport for Unigene cluster for CNTD2 Gene:

Hs.631603
genes like me logo Genes that share expression patterns with CNTD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNTD2 Gene

Orthologs for CNTD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTD2 31 30
  • 98.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CNTD2 31 30
  • 82.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CNTD2 31 30
  • 78.94 (n)
OneToOne
Species where no ortholog for CNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTD2 Gene

ENSEMBL:
Gene Tree for CNTD2 (if available)
TreeFam:
Gene Tree for CNTD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNTD2: view image

Paralogs for CNTD2 Gene

(3) SIMAP similar genes for CNTD2 Gene using alignment to 3 proteins:

  • CNTD2_HUMAN
  • D6RCS3_HUMAN
  • M0QZM5_HUMAN
genes like me logo Genes that share paralogs with CNTD2: view

Variants for CNTD2 Gene

Additional dbSNP identifiers (rs#s) for CNTD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CNTD2 Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372

Variation tolerance for CNTD2 Gene

Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNTD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNTD2 Gene

Disorders for CNTD2 Gene

Additional Disease Information for CNTD2

No disorders were found for CNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNTD2 Gene

Publications for CNTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Can sequencing shed light on cell cycling? (PMID: 11237006) Murray AW … Marks D (Nature 2001) 2 3 54
  3. The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration. (PMID: 30087414) Sánchez-Botet A … Clotet J (Scientific reports 2018) 3 54
  4. A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. (PMID: 28860486) Gasa L … Clotet J (Scientific reports 2017) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for CNTD2 Gene

Sources for CNTD2 Gene