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Aliases for CNRIP1 Gene

Aliases for CNRIP1 Gene

  • Cannabinoid Receptor Interacting Protein 1 2 3 5
  • C2orf32 3 4
  • CRIP-1 3 4
  • CB1 Cannabinoid Receptor-Interacting Protein 1 3
  • Cannabinoid Receptor CB1-Interacting Protein 1 3
  • Chromosome 2 Open Reading Frame 32 2
  • CRIP1 3

External Ids for CNRIP1 Gene

Previous HGNC Symbols for CNRIP1 Gene

  • C2orf32

Previous GeneCards Identifiers for CNRIP1 Gene

  • GC02M068373
  • GC02M068511

Summaries for CNRIP1 Gene

Entrez Gene Summary for CNRIP1 Gene

  • This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CNRIP1 Gene

CNRIP1 (Cannabinoid Receptor Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CNRIP1 Gene

  • Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.

Additional gene information for CNRIP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNRIP1 Gene

Genomics for CNRIP1 Gene

GeneHancer (GH) Regulatory Elements for CNRIP1 Gene

Promoters and enhancers for CNRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I068317 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 559.5 +0.8 796 2.9 ZFP64 SIN3A FEZF1 YY1 GLIS2 ZNF143 SP3 MIER2 REST ZNF184 CNRIP1 ENSG00000273398 LOC102724389 GC02P067636
GH02I068120 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.2 +198.9 198919 1.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT FEZF1 IRF4 YY1 ZNF766 E2F8 WDR92 PNO1 CNRIP1 C1D PPIAP64 LOC105374789 GC02P067636
GH02I068410 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.3 -92.5 -92500 3.2 MEIS2 PKNOX1 EBF1 CEBPG BMI1 ZNF766 POLR2A ATF7 ZSCAN29 IKZF2 PLEK LOC101927723 CNRIP1 LOC391383 GC02P067636
GH02I068436 Enhancer 0.9 Ensembl dbSUPER 11 -116.7 -116650 0.6 HDAC1 MEIS2 L3MBTL2 SOX6 TEAD4 BHLHE40 E2F5 CBFA2T3 ZEB2 ELF1 LOC101927723 PLEK CNRIP1 LOC391383 GC02P067636
GH02I068402 Enhancer 1 ENCODE dbSUPER 8.1 -83.5 -83478 2.1 HDAC1 FOXA2 BMI1 CHAMP1 TCF12 ZNF766 ATF7 IKZF2 RUNX3 ZBTB11 CNRIP1 PLEK LOC101927723 LOC391383 GC02P067636
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNRIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNRIP1 gene promoter:

Genomic Locations for CNRIP1 Gene

Genomic Locations for CNRIP1 Gene
35,881 bases
Minus strand

Genomic View for CNRIP1 Gene

Genes around CNRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNRIP1 Gene

Proteins for CNRIP1 Gene

  • Protein details for CNRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CB1 cannabinoid receptor-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R4D0
    • Q49AN4
    • Q9UFZ0

    Protein attributes for CNRIP1 Gene

    164 amino acids
    Molecular mass:
    18648 Da
    Quaternary structure:
    • Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.

    Alternative splice isoforms for CNRIP1 Gene


neXtProt entry for CNRIP1 Gene

Post-translational modifications for CNRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNRIP1 Gene

No data available for DME Specific Peptides for CNRIP1 Gene

Domains & Families for CNRIP1 Gene

Gene Families for CNRIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNRIP1 Gene


Suggested Antigen Peptide Sequences for CNRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CNRIP family.
  • Belongs to the CNRIP family.
genes like me logo Genes that share domains with CNRIP1: view

Function for CNRIP1 Gene

Molecular function for CNRIP1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.

Phenotypes From GWAS Catalog for CNRIP1 Gene

Gene Ontology (GO) - Molecular Function for CNRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008022 protein C-terminus binding IDA,IEA 17895407
GO:0031718 type 1 cannabinoid receptor binding IPI 17895407
genes like me logo Genes that share ontologies with CNRIP1: view
genes like me logo Genes that share phenotypes with CNRIP1: view

Animal Model Products

miRNA for CNRIP1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNRIP1 Gene

Localization for CNRIP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNRIP1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17895407
GO:0005886 plasma membrane IDA 17895407
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with CNRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNRIP1 Gene

Pathways & Interactions for CNRIP1 Gene

SuperPathways for CNRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNRIP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CNRIP1 Gene

Drugs & Compounds for CNRIP1 Gene

(1) Drugs for CNRIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CNRIP1: view

Transcripts for CNRIP1 Gene

Unigene Clusters for CNRIP1 Gene

Cannabinoid receptor interacting protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNRIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for CNRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNRIP1 Gene

This gene is overexpressed in Brain (17.0) and Frontal cortex (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNRIP1 Gene

Protein tissue co-expression partners for CNRIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNRIP1 Gene:


SOURCE GeneReport for Unigene cluster for CNRIP1 Gene:


Evidence on tissue expression from TISSUES for CNRIP1 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with CNRIP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNRIP1 Gene

Orthologs for CNRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNRIP1 33 34
  • 99.39 (n)
(Bos Taurus)
Mammalia CNRIP1 33 34
  • 93.5 (n)
(Monodelphis domestica)
Mammalia CNRIP1 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia CNRIP1 34
  • 92 (a)
(Canis familiaris)
Mammalia CNRIP1 33 34
  • 90.64 (n)
(Mus musculus)
Mammalia Cnrip1 33 16 34
  • 90.04 (n)
(Rattus norvegicus)
Mammalia Cnrip1 33
  • 89.84 (n)
(Gallus gallus)
Aves CNRIP1 33 34
  • 72.88 (n)
(Anolis carolinensis)
Reptilia CNRIP1 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnrip1 33
  • 69.15 (n)
Str.17250 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.28904 33
(Danio rerio)
Actinopterygii cnrip1b 33 34
  • 64.4 (n)
cnrip1a 34
  • 61 (a)
Dr.6763 33
(Caenorhabditis elegans)
Secernentea F29A7.4 34
  • 19 (a)
Species where no ortholog for CNRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNRIP1 Gene

Gene Tree for CNRIP1 (if available)
Gene Tree for CNRIP1 (if available)

Paralogs for CNRIP1 Gene

No data available for Paralogs for CNRIP1 Gene

Variants for CNRIP1 Gene

Sequence variations from dbSNP and Humsavar for CNRIP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006430 -- 68,304,114(-) G/A intron_variant
rs1000008838 -- 68,295,672(-) T/C intron_variant
rs1000049874 -- 68,286,374(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000251477 -- 68,293,766(-) A/T 3_prime_UTR_variant, intron_variant
rs1000269640 -- 68,289,591(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv221n21 CNV loss 19592680
nsv524297 CNV loss 19592680

Variation tolerance for CNRIP1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNRIP1 Gene

Disorders for CNRIP1 Gene

Additional Disease Information for CNRIP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CNRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNRIP1 Gene

Publications for CNRIP1 Gene

  1. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? (PMID: 20590557) Smith TH … Selley DE (British journal of pharmacology 2010) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. (PMID: 17895407) Niehaus JL … Lewis DL (Molecular pharmacology 2007) 3 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CNRIP1 Gene

Sources for CNRIP1 Gene

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