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Aliases for CNR2 Gene

Aliases for CNR2 Gene

  • Cannabinoid Receptor 2 2 3 3 5
  • Cannabinoid Receptor 2 (Macrophage) 2 3
  • CB-2 3 4
  • CB2 3 4
  • CX5 3 4
  • Testis-Dominant CNR2 Isoform CB2 3
  • CB2A 4
  • CB2B 4
  • HCB2 4

External Ids for CNR2 Gene

Previous GeneCards Identifiers for CNR2 Gene

  • GC01M023725
  • GC01M023271
  • GC01M9A0006
  • GC01M9A3945
  • GC01M023945
  • GC01M024069
  • GC01M024197
  • GC01M022452

Summaries for CNR2 Gene

Entrez Gene Summary for CNR2 Gene

  • The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNR2 Gene

CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot for CNR2 Gene

  • Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Tocris Summary for CNR2 Gene

  • The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. CB2 receptors are located primarily in immune cells both within and outside the CNS.

Gene Wiki entry for CNR2 Gene

Additional gene information for CNR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR2 Gene

Genomics for CNR2 Gene

GeneHancer (GH) Regulatory Elements for CNR2 Gene

Promoters and enhancers for CNR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J023907 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.1 +2.4 2421 6.4 HDGF PKNOX1 FOXA2 SMAD1 IRF4 ZNF143 FOS ATF7 RUNX3 ZNF592 CNR2 FUCA1 NCMAP PNRC2 RPL11 ENSG00000232557
GH01J023975 Promoter/Enhancer 2.9 UCNEbase EPDnew Ensembl ENCODE dbSUPER 11.9 -65.5 -65475 6.4 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRSF10 ELOA SRRM1 LINC01355 KDM1A RPL11 ZNF436-AS1 PNRC2 CNR2 RUNX3
GH01J024014 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -106.0 -106007 9.3 PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B NEUROD1 FEZF1 DMAP1 ZNF2 SRSF10 LINC01355 SRRM1 HNRNPR PNRC2 CNR2 ENSG00000230703 MYOM3 LOC105376863 ENSG00000225315
GH01J023983 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 -71.4 -71411 1.9 FOXA2 NFIB INSM2 FEZF1 ZEB1 ZNF121 GATA3 POLR2A PRDM10 RCOR1 PNRC2 CNR2 SRSF10 LOC105378615
GH01J024028 Enhancer 0.6 Ensembl 11.5 -114.8 -114839 0.4 CTCF ZNF680 SAP130 TEAD1 FOXA3 TRIM22 ARID4B REST PPARG RAD21 SRSF10 PNRC2 CNR2 ENSG00000225315 LOC105376863
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNR2 gene promoter:
  • ATF-2
  • deltaCREB
  • CREB
  • c-Jun
  • AP-1
  • STAT1
  • STAT5A
  • GR-alpha
  • GR

Genomic Locations for CNR2 Gene

Genomic Locations for CNR2 Gene
42,837 bases
Minus strand
88,534 bases
Minus strand

Genomic View for CNR2 Gene

Genes around CNR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR2 Gene

Proteins for CNR2 Gene

  • Protein details for CNR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cannabinoid receptor 2
    Protein Accession:
    Secondary Accessions:
    • C6ES44
    • Q4VBK8
    • Q5JRH7
    • Q6B0G7
    • Q6NSY0

    Protein attributes for CNR2 Gene

    360 amino acids
    Molecular mass:
    39681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNR2 Gene

neXtProt entry for CNR2 Gene

Post-translational modifications for CNR2 Gene

  • Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • Glycosylation at posLast=1111
  • Modification sites at PhosphoSitePlus

Other Protein References for CNR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)
  • Boster Bio Antibodies for CNR2
  • Santa Cruz Biotechnology (SCBT) Antibodies for CNR2

No data available for DME Specific Peptides for CNR2 Gene

Domains & Families for CNR2 Gene

Gene Families for CNR2 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for CNR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR2: view

Function for CNR2 Gene

Molecular function for CNR2 Gene

UniProtKB/Swiss-Prot Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
UniProtKB/Swiss-Prot Induction:
In macrophages, down-regulated by endocannabinoid anandamide/AEA.
GENATLAS Biochemistry:
cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase

Phenotypes From GWAS Catalog for CNR2 Gene

Gene Ontology (GO) - Molecular Function for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004949 cannabinoid receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with CNR2: view
genes like me logo Genes that share phenotypes with CNR2: view

Animal Models for CNR2 Gene

MGI Knock Outs for CNR2:

Animal Model Products

miRNA for CNR2 Gene

miRTarBase miRNAs that target CNR2

Clone Products

  • Addgene plasmids for CNR2
  • R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR2 Gene

Localization for CNR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8679694
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with CNR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CNR2 Gene

Pathways & Interactions for CNR2 Gene

genes like me logo Genes that share pathways with CNR2: view

Pathways by source for CNR2 Gene

Gene Ontology (GO) - Biological Process for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 7556170
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CNR2: view

No data available for SIGNOR curated interactions for CNR2 Gene

Drugs & Compounds for CNR2 Gene

(78) Drugs for CNR2 Gene - From: DrugBank, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dronabinol Approved, Illicit Pharma Target, agonist 160
Nabilone Approved, Investigational Pharma Target, partial agonist 21
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist, Antagonist, Channel blocker, Activator, Target, antagonist 0
Rimonabant Approved, Investigational Pharma Antagonist CB1 receptor antagonist 46
Lasofoxifene Approved, Investigational Pharma Target, inverse agonist 0

(16) Additional Compounds for CNR2 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Partial agonist, Agonist, Potentiation, Allosteric regulator, Full agonist, Activator, Channel blocker
GW 405833
JWH 015
JWH 133
JWH 133 (in Tocrisolve 100)

(5) Tocris Compounds for CNR2 Gene

Compound Action Cas Number
GW 405833 Selective, high affinity CB2 receptor partial agonist 180002-83-9
JWH 015 Selective CB2 agonist 155471-08-2
JWH 133 Potent, selective CB2 agonist 259869-55-1
JWH 133 (in Tocrisolve 100) Potent, selective CB2 agonist (in water-soluble emulsion) 259869-55-1
L-759,633 High affinity, selective CB2 agonist 174627-50-0
genes like me logo Genes that share compounds with CNR2: view

Transcripts for CNR2 Gene

mRNA/cDNA for CNR2 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNR2 Gene

Cannabinoid receptor 2 (macrophage):
Representative Sequences:

Clone Products

  • Addgene plasmids for CNR2
  • R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)

Alternative Splicing Database (ASD) splice patterns (SP) for CNR2 Gene

No ASD Table

Relevant External Links for CNR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNR2 Gene

This gene is overexpressed in Spleen (x19.6), Small Intestine - Terminal Ileum (x7.1), and Whole Blood (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNR2 Gene:


SOURCE GeneReport for Unigene cluster for CNR2 Gene:


mRNA Expression by UniProt/SwissProt for CNR2 Gene:

Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5 UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.

Evidence on tissue expression from TISSUES for CNR2 Gene

  • Blood(4.4)
  • Nervous system(4.4)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with CNR2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNR2 Gene

Orthologs for CNR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNR2 34 33
  • 99.26 (n)
(Canis familiaris)
Mammalia CNR2 34 33
  • 85 (n)
(Bos Taurus)
Mammalia CNR2 34 33
  • 84.22 (n)
(Mus musculus)
Mammalia Cnr2 16 34 33
  • 82.32 (n)
(Rattus norvegicus)
Mammalia Cnr2 33
  • 81.85 (n)
(Monodelphis domestica)
Mammalia CNR2 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CNR2 34
  • 57 (a)
(Gallus gallus)
Aves CNR2 34 33
  • 56.11 (n)
(Anolis carolinensis)
Reptilia CNR2 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr2 33
  • 54.98 (n)
(Danio rerio)
Actinopterygii cnr2 34 33
  • 51.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
-- 34
  • 21 (a)
Species where no ortholog for CNR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR2 Gene

Gene Tree for CNR2 (if available)
Gene Tree for CNR2 (if available)
Evolutionary constrained regions (ECRs) for CNR2: view image

Paralogs for CNR2 Gene

Paralogs for CNR2 Gene

(1) SIMAP similar genes for CNR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNR2: view

Variants for CNR2 Gene

Sequence variations from dbSNP and Humsavar for CNR2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000029053 -- 23,889,975(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000317078 -- 23,876,076(-) C/T intron_variant
rs1000379759 -- 23,881,403(-) C/A intron_variant
rs1000410652 -- 23,881,198(-) C/T intron_variant
rs1000489968 -- 23,874,539(-) C/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CNR2 Gene

Variant ID Type Subtype PubMed ID
dgv190n54 CNV loss 21841781
dgv191n54 CNV loss 21841781
dgv29n67 CNV loss 20364138
esv1663042 CNV insertion 17803354
esv2672735 CNV deletion 23128226
esv2745386 CNV deletion 23290073
esv29329 CNV loss 19812545
esv3585494 CNV loss 21293372
esv3585495 CNV loss 21293372
esv3893081 CNV gain 25118596
esv991485 CNV insertion 20482838
nsv1122310 CNV deletion 24896259
nsv1133021 OTHER inversion 24896259
nsv1145326 CNV deletion 24896259
nsv512727 CNV insertion 21212237
nsv545778 CNV loss 21841781

Variation tolerance for CNR2 Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNR2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR2 Gene

Disorders for CNR2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CNR2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cannabis abuse
  • marijuana abuse
glycerol kinase deficiency
  • gkd
chromosome xp21 deletion syndrome
  • complex glycerol kinase deficiency
alternating hemiplegia of childhood
  • ahc
multiple sclerosis
  • multiple sclerosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CNR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CNR2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CNR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNR2 Gene

Publications for CNR2 Gene

  1. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PMID: 18286196) Onaivi ES … Uhl GR (PloS one 2008) 3 4 22 44 58
  2. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A … Bergasa NV (Journal of gastroenterology 2010) 3 22 44 58
  3. Brain cannabinoid CB2 receptor in schizophrenia. (PMID: 19931854) Ishiguro H … Arinami T (Biological psychiatry 2010) 3 22 44 58
  4. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. (PMID: 19496827) Liu QR … Uhl GR (Genes, brain, and behavior 2009) 3 4 22 58
  5. The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. (PMID: 19565271) Karsak M … Livshits G (Human genetics 2009) 3 22 44 58

Products for CNR2 Gene

Sources for CNR2 Gene

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