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Aliases for CNPY4 Gene

Aliases for CNPY4 Gene

  • Canopy FGF Signaling Regulator 4 2 3 5
  • PRotein Associated With Tlr4 3
  • Protein Associated With TLR4 2
  • Canopy 4 Homolog (Zebrafish) 2
  • Protein Canopy Homolog 4 3
  • Canopy 4 Homolog 3
  • PRAT4B 3

External Ids for CNPY4 Gene

Previous GeneCards Identifiers for CNPY4 Gene

  • GC07P099556
  • GC07P099718
  • GC07P094352

Summaries for CNPY4 Gene

GeneCards Summary for CNPY4 Gene

CNPY4 (Canopy FGF Signaling Regulator 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CNPY3.

UniProtKB/Swiss-Prot for CNPY4 Gene

  • Plays a role in the regulation of the cell surface expression of TLR4.

Additional gene information for CNPY4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY4 Gene

Genomics for CNPY4 Gene

GeneHancer (GH) Regulatory Elements for CNPY4 Gene

Promoters and enhancers for CNPY4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100118 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 158 2.6 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B IRF4 TAF6 CNPY4 AP4M1 ZSCAN25 GIGYF1 SRRT ZNF655 STAG3L5P ZNF3 ENSG00000242798
GH07J099437 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.3 -680.2 -680240 3.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B CPSF4 PIR43796 AP4M1 TRRAP ZSCAN25 ZSCAN21 LOC100131859 CNPY4 TRIM4 PPP1R35
GH07J100124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29 +7.1 7060 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ENSG00000242798 MBLAC1 TAF6 GIGYF1 TRIM4 ZSCAN25 SRRT ZNF655 AP4M1 PPP1R35
GH07J100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.3 +358.1 358142 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF655 ZNF3 ENSG00000242798 STAG3L5P PPP1R35
GH07J100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 19.2 +313.6 313586 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE ZCWPW1 PIR54054 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 PILRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNPY4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNPY4 gene promoter:
  • Tal-1beta
  • MyoD
  • Elk-1
  • E47
  • Pax-4a
  • C/EBPbeta
  • c-Myc
  • Max1
  • FOXF2
  • ATF

Genomic Locations for CNPY4 Gene

Genomic Locations for CNPY4 Gene
5,899 bases
Plus strand
5,899 bases
Plus strand

Genomic View for CNPY4 Gene

Genes around CNPY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY4 Gene

Proteins for CNPY4 Gene

  • Protein details for CNPY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein canopy homolog 4
    Protein Accession:
    Secondary Accessions:
    • Q8WUN9

    Protein attributes for CNPY4 Gene

    248 amino acids
    Molecular mass:
    28310 Da
    Quaternary structure:
    • Interacts with TLR4.

neXtProt entry for CNPY4 Gene

Post-translational modifications for CNPY4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNPY4 Gene

Domains & Families for CNPY4 Gene

Gene Families for CNPY4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CNPY4 Gene


Suggested Antigen Peptide Sequences for CNPY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the canopy family.
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY4: view

Function for CNPY4 Gene

Molecular function for CNPY4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the cell surface expression of TLR4.

Phenotypes From GWAS Catalog for CNPY4 Gene

Gene Ontology (GO) - Molecular Function for CNPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 signaling receptor binding IEA --
genes like me logo Genes that share ontologies with CNPY4: view
genes like me logo Genes that share phenotypes with CNPY4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CNPY4

miRNA for CNPY4 Gene

miRTarBase miRNAs that target CNPY4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNPY4 Gene

Localization for CNPY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNPY4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with CNPY4: view

Pathways & Interactions for CNPY4 Gene

SuperPathways for CNPY4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903078 positive regulation of protein localization to plasma membrane IMP 16338228
genes like me logo Genes that share ontologies with CNPY4: view

No data available for Pathways by source and SIGNOR curated interactions for CNPY4 Gene

Drugs & Compounds for CNPY4 Gene

(1) Drugs for CNPY4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with CNPY4: view

Transcripts for CNPY4 Gene

mRNA/cDNA for CNPY4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(77) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNPY4 Gene

Canopy 4 homolog (zebrafish):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP4: -

Relevant External Links for CNPY4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNPY4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNPY4 Gene

Protein differential expression in normal tissues from HIPED for CNPY4 Gene

This gene is overexpressed in Adrenal (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNPY4 Gene

Protein tissue co-expression partners for CNPY4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNPY4 Gene:


SOURCE GeneReport for Unigene cluster for CNPY4 Gene:


Evidence on tissue expression from TISSUES for CNPY4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CNPY4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNPY4 Gene

Orthologs for CNPY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNPY4 34 33
  • 97.17 (n)
(Bos Taurus)
Mammalia CNPY4 34 33
  • 89.64 (n)
(Canis familiaris)
Mammalia CNPY4 34 33
  • 88.75 (n)
(Mus musculus)
Mammalia Cnpy4 16 34 33
  • 84.39 (n)
(Rattus norvegicus)
Mammalia Cnpy4 33
  • 83.96 (n)
(Monodelphis domestica)
Mammalia CNPY4 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia CNPY4 34
  • 46 (a)
(Danio rerio)
Actinopterygii cnpy4 34 33
  • 63.37 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3278 33
fruit fly
(Drosophila melanogaster)
Insecta CG11577 34 33
  • 56.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011140 33
  • 54.33 (n)
(Caenorhabditis elegans)
Secernentea C11H1.7 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5145 34
  • 51 (a)
Species where no ortholog for CNPY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY4 Gene

Gene Tree for CNPY4 (if available)
Gene Tree for CNPY4 (if available)
Evolutionary constrained regions (ECRs) for CNPY4: view image

Paralogs for CNPY4 Gene

Paralogs for CNPY4 Gene

(1) SIMAP similar genes for CNPY4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY4: view

Variants for CNPY4 Gene

Sequence variations from dbSNP and Humsavar for CNPY4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs755399414 uncertain-significance, not specified 100,119,722(+) TTGTTTGT/TTGT 5_prime_UTR_variant
rs1000349935 -- 100,122,528(+) T/C coding_sequence_variant, missense_variant
rs1000697193 -- 100,124,092(+) C/T intron_variant
rs1000757558 -- 100,118,519(+) T/C upstream_transcript_variant
rs1001198871 -- 100,120,019(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv607931 CNV loss 21841781

Variation tolerance for CNPY4 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNPY4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY4 Gene

Disorders for CNPY4 Gene

Additional Disease Information for CNPY4

No disorders were found for CNPY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY4 Gene

Publications for CNPY4 Gene

  1. A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. (PMID: 16338228) Konno K … Miyake K (Biochemical and biophysical research communications 2006) 3 4 22 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CNPY4 Gene

Sources for CNPY4 Gene

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