Aliases for CNPY2 Gene

Aliases for CNPY2 Gene

  • Canopy FGF Signaling Regulator 2 2 3 5
  • Transmembrane Protein 4 2 3 4
  • ZSIG9 2 3 4
  • MIR-Interacting Saposin-Like Protein 3 4
  • Putative Secreted Protein Zsig9 3 4
  • Protein Canopy Homolog 2 3 4
  • HP10390 2 3
  • TMEM4 3 4
  • MSAP 3 4
  • Canopy 2 Homolog (Zebrafish) 2
  • CNPY2 5

External Ids for CNPY2 Gene

Previous HGNC Symbols for CNPY2 Gene

  • TMEM4

Previous GeneCards Identifiers for CNPY2 Gene

  • GC12M054991
  • GC12M056704
  • GC12M053742

Summaries for CNPY2 Gene

GeneCards Summary for CNPY2 Gene

CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot Summary for CNPY2 Gene

  • Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNPY2 Gene

Genomics for CNPY2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CNPY2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNPY2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNPY2

Top Transcription factor binding sites by QIAGEN in the CNPY2 gene promoter:
  • CUTL1
  • GR
  • GR-alpha
  • Nkx2-5
  • STAT1
  • STAT5A

Genomic Locations for CNPY2 Gene

Latest Assembly
6,505 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
6,503 bases
Minus strand

(GRCh37/hg19 by Ensembl)
6,495 bases
Minus strand

Genomic View for CNPY2 Gene

Genes around CNPY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY2 Gene

Proteins for CNPY2 Gene

  • Protein details for CNPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein canopy homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R7B9
    • Q9UHE9

    Protein attributes for CNPY2 Gene

    182 amino acids
    Molecular mass:
    20652 Da
    Quaternary structure:
    • Interacts with MYLIP/MIR.

    Alternative splice isoforms for CNPY2 Gene


neXtProt entry for CNPY2 Gene

Post-translational modifications for CNPY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY2 Gene

No data available for DME Specific Peptides for CNPY2 Gene

Domains & Families for CNPY2 Gene

Gene Families for CNPY2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CNPY2 Gene

  • Saposin B

Suggested Antigen Peptide Sequences for CNPY2 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 4 (CNPY2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the canopy family.
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY2: view

Function for CNPY2 Gene

Molecular function for CNPY2 Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

Phenotypes From GWAS Catalog for CNPY2 Gene

Gene Ontology (GO) - Molecular Function for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12826659
genes like me logo Genes that share ontologies with CNPY2: view
genes like me logo Genes that share phenotypes with CNPY2: view

Animal Models for CNPY2 Gene

MGI Knock Outs for CNPY2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNPY2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CNPY2 Gene

Localization for CNPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY2 Gene

Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNPY2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
genes like me logo Genes that share ontologies with CNPY2: view

Pathways & Interactions for CNPY2 Gene

PathCards logo

SuperPathways for CNPY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression ISS 22378787
GO:0010988 regulation of low-density lipoprotein particle clearance ISS 22378787
GO:1905599 positive regulation of low-density lipoprotein receptor activity ISS 22378787
genes like me logo Genes that share ontologies with CNPY2: view

No data available for Pathways by source and SIGNOR curated interactions for CNPY2 Gene

Drugs & Compounds for CNPY2 Gene

No Compound Related Data Available

Transcripts for CNPY2 Gene

mRNA/cDNA for CNPY2 Gene

13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNPY2

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY2 Gene

No ASD Table

Relevant External Links for CNPY2 Gene

GeneLoc Exon Structure for

Expression for CNPY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNPY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNPY2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8) and Nasal epithelium (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNPY2 Gene

Protein tissue co-expression partners for CNPY2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNPY2

SOURCE GeneReport for Unigene cluster for CNPY2 Gene:


mRNA Expression by UniProt/SwissProt for CNPY2 Gene:

Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.

Evidence on tissue expression from TISSUES for CNPY2 Gene

  • Skin(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with CNPY2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNPY2 Gene

Orthologs for CNPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNPY2 30
  • 99.82 (n)
(Canis familiaris)
Mammalia CNPY2 30
  • 95.05 (n)
-- 31
  • 89 (a)
(Bos Taurus)
Mammalia CNPY2 30 31
  • 93.22 (n)
(Rattus norvegicus)
Mammalia Cnpy2 30
  • 91.77 (n)
(Mus musculus)
Mammalia Cnpy2 30 17 31
  • 91.57 (n)
(Gallus gallus)
Aves CNPY2 30
  • 69.05 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 72 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cnpy2 30
  • 70.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19577 30
(Danio rerio)
Actinopterygii cnpy2 30 31
  • 69.98 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9940 30
Fruit Fly
(Drosophila melanogaster)
Insecta sel 31
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F01F1.15 31
  • 30 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4160 31
  • 40 (a)
Species where no ortholog for CNPY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CNPY2 Gene

Gene Tree for CNPY2 (if available)
Gene Tree for CNPY2 (if available)
Evolutionary constrained regions (ECRs) for CNPY2: view image

Paralogs for CNPY2 Gene

Paralogs for CNPY2 Gene

(1) SIMAP similar genes for CNPY2 Gene using alignment to 5 proteins:

  • F8W1K5_HUMAN
  • H0YI18_HUMAN
genes like me logo Genes that share paralogs with CNPY2: view

Variants for CNPY2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CNPY2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CNPY2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for CNPY2 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNPY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNPY2 Gene

Disorders for CNPY2 Gene

Additional Disease Information for CNPY2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CNPY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY2 Gene

Publications for CNPY2 Gene

  1. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PMID: 12826659) Bornhauser BC … Lindholm D (The Journal of biological chemistry 2003) 3 4 23
  2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M … Kato S (Gene 1999) 2 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  4. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PMID: 15905959) Bornhauser BC … Lindholm D (Cellular and molecular life sciences : CMLS 2005) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CNPY2 Gene

Sources for CNPY2 Gene