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Aliases for CNPY2 Gene

Aliases for CNPY2 Gene

  • Canopy FGF Signaling Regulator 2 2 3 5
  • Transmembrane Protein 4 2 3 4
  • MIR-Interacting Saposin-Like Protein 3 4
  • Putative Secreted Protein Zsig9 3 4
  • TMEM4 3 4
  • ZSIG9 3 4
  • MSAP 3 4
  • Canopy 2 Homolog (Zebrafish) 2
  • Protein Canopy Homolog 2 3
  • HP10390 3

External Ids for CNPY2 Gene

Previous HGNC Symbols for CNPY2 Gene

  • TMEM4

Previous GeneCards Identifiers for CNPY2 Gene

  • GC12M054991
  • GC12M056704
  • GC12M053742

Summaries for CNPY2 Gene

GeneCards Summary for CNPY2 Gene

CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot for CNPY2 Gene

  • Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

Additional gene information for CNPY2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY2 Gene

Genomics for CNPY2 Gene

GeneHancer (GH) Regulatory Elements for CNPY2 Gene

Promoters and enhancers for CNPY2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I056314 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 445 2.8 PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ZNF766 CNPY2 ENSG00000144785 ENSG00000257303 ENSG00000257740 PAN2 GC12P056293
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +93.5 93462 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 RNF41 NABP2 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.9 -794.9 -794910 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056298 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 +15.5 15534 4.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ENSG00000257303 CS BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41 MMP19
GH12I056266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +49.2 49150 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 COQ10A GC12M056238 NEMP1 PAN2 BAZ2A PHC1P1 ANKRD52 DNAJC14 SMARCC2 RN7SL809P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNPY2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNPY2 gene promoter:

Genomic Locations for CNPY2 Gene

Genomic Locations for CNPY2 Gene
chr12:56,309,842-56,316,344
(GRCh38/hg38)
Size:
6,503 bases
Orientation:
Minus strand
chr12:56,703,626-56,710,128
(GRCh37/hg19)

Genomic View for CNPY2 Gene

Genes around CNPY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY2 Gene

Proteins for CNPY2 Gene

  • Protein details for CNPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2B0-CNPY2_HUMAN
    Recommended name:
    Protein canopy homolog 2
    Protein Accession:
    Q9Y2B0
    Secondary Accessions:
    • B2R7B9
    • Q9UHE9

    Protein attributes for CNPY2 Gene

    Size:
    182 amino acids
    Molecular mass:
    20652 Da
    Quaternary structure:
    • Interacts with MYLIP/MIR.

    Alternative splice isoforms for CNPY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNPY2 Gene

Post-translational modifications for CNPY2 Gene

No Post-translational modifications

Other Protein References for CNPY2 Gene

No data available for DME Specific Peptides for CNPY2 Gene

Domains & Families for CNPY2 Gene

Gene Families for CNPY2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CNPY2 Gene

Suggested Antigen Peptide Sequences for CNPY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2B0

UniProtKB/Swiss-Prot:

CNPY2_HUMAN :
  • Belongs to the canopy family.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY2: view

Function for CNPY2 Gene

Molecular function for CNPY2 Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

Phenotypes From GWAS Catalog for CNPY2 Gene

Gene Ontology (GO) - Molecular Function for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12826659
genes like me logo Genes that share ontologies with CNPY2: view
genes like me logo Genes that share phenotypes with CNPY2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CNPY2 Gene

Localization for CNPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNPY2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005887 integral component of plasma membrane TAS 10072769
genes like me logo Genes that share ontologies with CNPY2: view

Pathways & Interactions for CNPY2 Gene

SuperPathways for CNPY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007167 enzyme linked receptor protein signaling pathway IBA --
GO:0009888 tissue development IBA --
GO:0010629 negative regulation of gene expression ISS 22378787
GO:0010988 regulation of low-density lipoprotein particle clearance ISS 22378787
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS 22378787
genes like me logo Genes that share ontologies with CNPY2: view

No data available for Pathways by source and SIGNOR curated interactions for CNPY2 Gene

Drugs & Compounds for CNPY2 Gene

No Compound Related Data Available

Transcripts for CNPY2 Gene

Unigene Clusters for CNPY2 Gene

Canopy 2 homolog (zebrafish):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY2 Gene

No ASD Table

Relevant External Links for CNPY2 Gene

GeneLoc Exon Structure for
CNPY2
ECgene alternative splicing isoforms for
CNPY2

Expression for CNPY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNPY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNPY2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8) and Nasal epithelium (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNPY2 Gene



Protein tissue co-expression partners for CNPY2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNPY2 Gene:

CNPY2

SOURCE GeneReport for Unigene cluster for CNPY2 Gene:

Hs.8752

mRNA Expression by UniProt/SwissProt for CNPY2 Gene:

Q9Y2B0-CNPY2_HUMAN
Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.

Evidence on tissue expression from TISSUES for CNPY2 Gene

  • Eye(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with CNPY2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNPY2 Gene

Orthologs for CNPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNPY2 33
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia CNPY2 33
  • 95.05 (n)
-- 34
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CNPY2 33 34
  • 93.22 (n)
rat
(Rattus norvegicus)
Mammalia Cnpy2 33
  • 91.77 (n)
mouse
(Mus musculus)
Mammalia Cnpy2 33 16 34
  • 91.57 (n)
chicken
(Gallus gallus)
Aves CNPY2 33
  • 69.05 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cnpy2 33
  • 70.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19577 33
zebrafish
(Danio rerio)
Actinopterygii cnpy2 33 34
  • 69.98 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9940 33
fruit fly
(Drosophila melanogaster)
Insecta sel 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F01F1.15 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 34
  • 40 (a)
OneToMany
Species where no ortholog for CNPY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNPY2 Gene

ENSEMBL:
Gene Tree for CNPY2 (if available)
TreeFam:
Gene Tree for CNPY2 (if available)

Paralogs for CNPY2 Gene

Paralogs for CNPY2 Gene

(1) SIMAP similar genes for CNPY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNPY2: view

Variants for CNPY2 Gene

Sequence variations from dbSNP and Humsavar for CNPY2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000664012 -- 56,317,908(-) G/A upstream_transcript_variant
rs1000680863 -- 56,317,021(-) G/A upstream_transcript_variant
rs1000807604 -- 56,313,446(-) T/C genic_downstream_transcript_variant, intron_variant
rs1001056227 -- 56,316,740(-) G/A/T upstream_transcript_variant
rs1001494557 -- 56,316,635(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for CNPY2 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNPY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNPY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY2 Gene

Disorders for CNPY2 Gene

Additional Disease Information for CNPY2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CNPY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY2 Gene

Publications for CNPY2 Gene

  1. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PMID: 12826659) Bornhauser BC … Lindholm D (The Journal of biological chemistry 2003) 3 4 22 58
  2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M … Kato S (Gene 1999) 2 3 4 58
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  4. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PMID: 15905959) Bornhauser BC … Lindholm D (Cellular and molecular life sciences : CMLS 2005) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CNPY2 Gene

Sources for CNPY2 Gene

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