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Aliases for CNPY1 Gene

Aliases for CNPY1 Gene

  • Canopy FGF Signaling Regulator 1 2 3 5
  • Canopy 1 Homolog (Zebrafish) 2
  • Protein Canopy Homolog 1 3
  • Canopy 1 Homolog 3

External Ids for CNPY1 Gene

Previous GeneCards Identifiers for CNPY1 Gene

  • GC07M154649
  • GC07M154976
  • GC07M155266
  • GC07M149023

Summaries for CNPY1 Gene

Entrez Gene Summary for CNPY1 Gene

  • Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]

GeneCards Summary for CNPY1 Gene

CNPY1 (Canopy FGF Signaling Regulator 1) is a Protein Coding gene. An important paralog of this gene is CNPY2.

Additional gene information for CNPY1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY1 Gene

Genomics for CNPY1 Gene

GeneHancer (GH) Regulatory Elements for CNPY1 Gene

Promoters and enhancers for CNPY1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J155570 Promoter 0.6 EPDnew 650.4 -15.3 -15316 0.1 KLF1 CNPY1 PIR45075 ENSG00000283128
GH07J155471 Enhancer 1 VISTA ENCODE 11.2 +83.2 83217 1.8 ZSCAN4 ZBTB8A ZIC2 GLIS2 POLR2A GLIS1 ZNF341 ZNF600 EGR2 EZH2 ENSG00000227365 CNPY1 BLACE EN2
GH07J155767 Enhancer 0.9 ENCODE dbSUPER 10.8 -214.2 -214185 3.5 HDGF CTCF RB1 MAX ZNF2 RAD21 CC2D1A ARID2 SMC3 RBM22 CNPY1 EN2 ENSG00000236544 RBM33 PIR49030 ENSG00000216895
GH07J155584 Enhancer 0.3 ENCODE 11.2 -29.5 -29451 0.2 RCOR1 CNPY1 PIR45075 ENSG00000283128
GH07J155467 Enhancer 0.6 FANTOM5 1.6 +87.4 87414 0.2 SP3 SP2 SIN3A EBF1 ZBTB8A KLF14 ZNF335 GLIS2 GLIS1 ZNF341 CNPY1 EN2 ENSG00000227365
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNPY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNPY1 gene promoter:
  • SRF (504 AA)
  • SRF
  • LCR-F1
  • Evi-1
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • ATF6
  • COMP1

Genomic Locations for CNPY1 Gene

Genomic Locations for CNPY1 Gene
81,245 bases
Minus strand
59,657 bases
Minus strand

Genomic View for CNPY1 Gene

Genes around CNPY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY1 Gene

Proteins for CNPY1 Gene

  • Protein details for CNPY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein canopy homolog 1
    Protein Accession:
    Secondary Accessions:
    • A6NGX3

    Protein attributes for CNPY1 Gene

    92 amino acids
    Molecular mass:
    10960 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNPY1 Gene

Post-translational modifications for CNPY1 Gene

No Post-translational modifications

Other Protein References for CNPY1 Gene

No data available for DME Specific Peptides for CNPY1 Gene

Domains & Families for CNPY1 Gene

Gene Families for CNPY1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNPY1 Gene


Suggested Antigen Peptide Sequences for CNPY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the canopy family.
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY1: view

Function for CNPY1 Gene

Phenotypes From GWAS Catalog for CNPY1 Gene

Phenotypes for CNPY1 Gene

MGI mutant phenotypes for CNPY1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CNPY1: view

Animal Models for CNPY1 Gene

MGI Knock Outs for CNPY1:
  • Cnpy1 Cnpy1<tm1(KOMP)Wtsi>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CNPY1 Gene

Localization for CNPY1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNPY1 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CNPY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with CNPY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CNPY1 Gene

Pathways & Interactions for CNPY1 Gene

SuperPathways for CNPY1 Gene

No Data Available

Interacting Proteins for CNPY1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000317439 for CNPY1 Gene via STRING

Gene Ontology (GO) - Biological Process for CNPY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007167 enzyme linked receptor protein signaling pathway IBA --
GO:0009888 tissue development IBA --
genes like me logo Genes that share ontologies with CNPY1: view

No data available for Pathways by source and SIGNOR curated interactions for CNPY1 Gene

Drugs & Compounds for CNPY1 Gene

No Compound Related Data Available

Transcripts for CNPY1 Gene

mRNA/cDNA for CNPY1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNPY1 Gene

Canopy 1 homolog (zebrafish):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY1 Gene

No ASD Table

Relevant External Links for CNPY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNPY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNPY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNPY1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x24.3) and Brain - Cerebellum (x23.5).

Protein differential expression in normal tissues from HIPED for CNPY1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNPY1 Gene

Protein tissue co-expression partners for CNPY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNPY1 Gene:


SOURCE GeneReport for Unigene cluster for CNPY1 Gene:

genes like me logo Genes that share expression patterns with CNPY1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNPY1 Gene

Orthologs for CNPY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNPY1 34 33
  • 98.91 (n)
(Canis familiaris)
Mammalia CNPY1 34 33
  • 89.13 (n)
(Bos Taurus)
Mammalia CNPY1 34 33
  • 86.96 (n)
(Mus musculus)
Mammalia Cnpy1 16 34 33
  • 82.3 (n)
(Rattus norvegicus)
Mammalia Cnpy1 33
  • 81.32 (n)
(Monodelphis domestica)
Mammalia CNPY1 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia CNPY1 34
  • 43 (a)
(Anolis carolinensis)
Reptilia CNPY1 34
  • 32 (a)
(Danio rerio)
Actinopterygii cnpy1 34
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta sel 34
  • 10 (a)
(Caenorhabditis elegans)
Secernentea F01F1.15 34
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 34
  • 16 (a)
Species where no ortholog for CNPY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY1 Gene

Gene Tree for CNPY1 (if available)
Gene Tree for CNPY1 (if available)
Evolutionary constrained regions (ECRs) for CNPY1: view image

Paralogs for CNPY1 Gene

Paralogs for CNPY1 Gene

(1) SIMAP similar genes for CNPY1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY1: view

Variants for CNPY1 Gene

Sequence variations from dbSNP and Humsavar for CNPY1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000039913 -- 155,511,721(-) C/A/T intron_variant
rs1000071078 -- 155,512,034(-) A/G intron_variant
rs1000102610 -- 155,516,259(-) T/C/G intron_variant
rs1000267620 -- 155,505,644(-) T/C intron_variant
rs1000313885 -- 155,526,089(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY1 Gene

Variant ID Type Subtype PubMed ID
nsv6017 CNV insertion 18451855
nsv824408 CNV gain 20364138
nsv831196 CNV gain 17160897

Variation tolerance for CNPY1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNPY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY1 Gene

Disorders for CNPY1 Gene

Additional Disease Information for CNPY1

No disorders were found for CNPY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY1 Gene

Publications for CNPY1 Gene

  1. Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. (PMID: 16488878) Hirate Y … Okamoto H (Current biology : CB 2006) 2 3 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 58

Products for CNPY1 Gene

Sources for CNPY1 Gene

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