Aliases for CNOT8 Gene
External Ids for CNOT8 Gene
Previous HGNC Symbols for CNOT8 Gene
Previous GeneCards Identifiers for CNOT8 Gene
GeneCards Summary for CNOT8 Gene
CNOT8 (CCR4-NOT Transcription Complex Subunit 8) is a Protein Coding gene. Diseases associated with CNOT8 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT7.
UniProtKB/Swiss-Prot Summary for CNOT8 Gene
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.