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The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Diseases associated with CNOT7 include Pontocerebellar Hypoplasia, Type 7 and Oligoasthenoteratozoospermia. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000175 | 3'-5'-exoribonuclease activity | IEA,IDA | 15769875 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003714 | transcription corepressor activity | IMP | 23386060 |
GO:0003723 | RNA binding | IEA | -- |
GO:0004518 | nuclease activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | ISS | -- |
GO:0005634 | nucleus | IEA,IDA | 9820826 |
GO:0005737 | cytoplasm | IMP | 23386060 |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Deadenylation-dependent mRNA decay |
.46
|
|
2 | Gene Expression |
.48
|
|
3 | TP53 Regulates Transcription of Cell Cycle Genes | ||
4 | Translational Control | ||
5 | Cyclins and Cell Cycle Regulation |
Cell Cycle Control by BTG Proteins
.36
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | -- |
GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA | IEA | -- |
GO:0006417 | regulation of translation | IEA | -- |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
GO:0008284 | positive regulation of cell proliferation | IMP | 19605561 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 12c | ^ | 13a | · | 13b | ^ | 14 |
---|---|---|---|---|---|---|---|
SP1: | - | ||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | |||||||
SP11: | |||||||
SP12: | |||||||
SP13: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CNOT7 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CNOT7 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CNOT7 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CNOT7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CNOT7 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cnot7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cnot7 30 |
|
||
Chicken (Gallus gallus) |
Aves | CNOT7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CNOT7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cnot7 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cnot7 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5684 32 |
|
|
|
Pop2 30 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011413 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ccf-1 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | POP2 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G10960 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | caf1 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09001 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.13234 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
671125 | Benign: not provided | 17,246,679(-) | G/A | FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
pontocerebellar hypoplasia, type 7 |
|
|
oligoasthenoteratozoospermia |
|
|