Aliases for CNOT7 Gene
External Ids for CNOT7 Gene
Previous HGNC Symbols for CNOT7 Gene
Previous GeneCards Identifiers for CNOT7 Gene
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
GeneCards Summary for CNOT7 Gene
CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Diseases associated with CNOT7 include Pontocerebellar Hypoplasia, Type 7 and Oligoasthenoteratozoospermia. Among its related pathways are Deadenylation-dependent mRNA decay and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.
UniProtKB/Swiss-Prot Summary for CNOT7 Gene
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.