CNOT7 Gene (Protein Coding)

CCR4-NOT Transcription Complex Subunit 7

GC08M017224
GIFtS:
40
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encode... See more...

Aliases for CNOT7 Gene

Aliases for CNOT7 Gene

  • CCR4-NOT Transcription Complex Subunit 7 2 3 4 5
  • CCR4-Associated Factor 1 3 4
  • BTG1-Binding Factor 1 3 4
  • CAF-1 3 4
  • Caf1a 3 4
  • CAF1 3 4
  • Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 1 3
  • CCR4-NOT Transcription Complex, Subunit 7 2
  • BTG1 Binding Factor 1 2
  • EC 3.1.13.4 4
  • HCAF-1 3
  • CNOT7 5

External Ids for CNOT7 Gene

Previous HGNC Symbols for CNOT7 Gene

  • CAF1

Previous GeneCards Identifiers for CNOT7 Gene

  • GC08M016980
  • GC08M017166
  • GC08M017097
  • GC08M017131
  • GC08M017086
  • GC08M015631

Summaries for CNOT7 Gene

Entrez Gene Summary for CNOT7 Gene

  • The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

GeneCards Summary for CNOT7 Gene

CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Diseases associated with CNOT7 include Pontocerebellar Hypoplasia, Type 7 and Oligoasthenoteratozoospermia. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.

UniProtKB/Swiss-Prot Summary for CNOT7 Gene

  • Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Wiki entry for CNOT7 Gene

Additional gene information for CNOT7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNOT7 Gene

Genomics for CNOT7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CNOT7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNOT7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNOT7

Top Transcription factor binding sites by QIAGEN in the CNOT7 gene promoter:
  • Cdc5
  • FOXI1
  • HFH-3
  • LCR-F1
  • Pax-5
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • RP58

Genomic Locations for CNOT7 Gene

Genomic Locations for CNOT7 Gene
chr8:17,221,981-17,246,909
(GRCh38/hg38)
Size:
24,929 bases
Orientation:
Minus strand
chr8:17,086,737-17,104,387
(GRCh37/hg19)
Size:
17,651 bases
Orientation:
Minus strand

Genomic View for CNOT7 Gene

Genes around CNOT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CNOT7 Gene

Proteins for CNOT7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CNOT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIV1-CNOT7_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 7
    Protein Accession:
    Q9UIV1
    Secondary Accessions:
    • A8MZM5
    • B3KMP1
    • B3KN35
    • D3DSP6
    • G3V108
    • Q7Z530

    Protein attributes for CNOT7 Gene

    Size:
    285 amino acids
    Molecular mass:
    32745 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:19558367). In the complex, interacts directly with CNOT1 (PubMed:21336257). Interacts with AGO2 (By similarity). Interacts with TOB1; recruited by TOB1 to a ternary complex with CPEB3 which is required for mRNA deadenylation and decay (PubMed:21336257, PubMed:23236473, PubMed:19276069). Interacts with BTG1 (By similarity). Interacts with BTG2 (PubMed:23236473). Interacts with NANOS2 (By similarity). Interacts with ZFP36, ZFP36L1 and ZFP36L2; these interactions are inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Interacts with TARDBP (PubMed:30520513).
    SequenceCaution:
    • Sequence=AAF01500.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT7 Gene

    Alternative splice isoforms for CNOT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT7 Gene

Protein Expression for CNOT7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CNOT7 Gene

  • Ubiquitination at Lys33, Lys206, and Lys240
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CNOT7
  • Santa Cruz Biotechnology (SCBT) Antibodies for CNOT7

No data available for DME Specific Peptides for CNOT7 Gene

Domains & Families for CNOT7 Gene

Gene Families for CNOT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CNOT7 Gene

InterPro:
Blocks:
  • CAF1 family ribonuclease
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT7 Gene

GenScript: Design optimal peptide antigens:
  • CCR4-associated factor 1 (CNOT7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UIV1

UniProtKB/Swiss-Prot:

CNOT7_HUMAN :
  • Belongs to the CAF1 family.
Family:
  • Belongs to the CAF1 family.
genes like me logo Genes that share domains with CNOT7: view

Function for CNOT7 Gene

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Molecular function for CNOT7 Gene

UniProtKB/Swiss-Prot Function:
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000269|PubMed:15769875, ECO:0000269|PubMed:19276069, ECO:0000269|PubMed:20634287};.

Enzyme Numbers (IUBMB) for CNOT7 Gene

Phenotypes From GWAS Catalog for CNOT7 Gene

Gene Ontology (GO) - Molecular Function for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IEA,IDA 15769875
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IMP 23386060
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
genes like me logo Genes that share ontologies with CNOT7: view
genes like me logo Genes that share phenotypes with CNOT7: view

Animal Models for CNOT7 Gene

MGI Knock Outs for CNOT7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNOT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT7 Gene

Localization for CNOT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT7 Gene

Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT7 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IEA,IDA 9820826
GO:0005737 cytoplasm IMP 23386060
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CNOT7: view

Pathways & Interactions for CNOT7 Gene

genes like me logo Genes that share pathways with CNOT7: view

Pathways by source for CNOT7 Gene

1 KEGG pathway for CNOT7 Gene
1 Qiagen pathway for CNOT7 Gene
  • Cell Cycle Control by BTG Proteins
1 Cell Signaling Technology pathway for CNOT7 Gene

Gene Ontology (GO) - Biological Process for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0008284 positive regulation of cell proliferation IMP 19605561
genes like me logo Genes that share ontologies with CNOT7: view

No data available for SIGNOR curated interactions for CNOT7 Gene

Drugs & Compounds for CNOT7 Gene

Products:

  1. Drug

(1) Additional Compounds for CNOT7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CNOT7: view

Transcripts for CNOT7 Gene

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  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for CNOT7 Gene

16 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNOT7

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13:

ExUns: 12c ^ 13a · 13b ^ 14
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CNOT7 Gene

GeneLoc Exon Structure for
CNOT7

Expression for CNOT7 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNOT7 Gene

mRNA expression in normal human tissues for CNOT7 Gene
mRNA expression by GTEx for CNOT7 GenemRNA expression by BioGPS for CNOT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT7 Gene

This gene is overexpressed in Bone (22.6) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNOT7 Gene



Protein tissue co-expression partners for CNOT7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNOT7

SOURCE GeneReport for Unigene cluster for CNOT7 Gene:

Hs.645009

Evidence on tissue expression from TISSUES for CNOT7 Gene

  • Nervous system(4.3)
  • Liver(2.3)
  • Lung(2.2)
  • Kidney(2.2)
  • Muscle(2.2)
  • Thyroid gland(2.1)
  • Heart(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with CNOT7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT7 Gene

Orthologs for CNOT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CNOT7 30 31
  • 100 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CNOT7 31
  • 99 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CNOT7 31
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CNOT7 30 31
  • 96.73 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CNOT7 30 31
  • 96.73 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cnot7 30 17 31
  • 93.1 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cnot7 30
  • 92.87 (n)
Chicken
(Gallus gallus)
 Aves CNOT7 30 31
  • 88.3 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CNOT7 31
  • 100 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cnot7 30
  • 82.57 (n)
Zebrafish
(Danio rerio)
 Actinopterygii cnot7 30 31
  • 80.87 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG5684 32
  • 75 (a)
Pop2 30 31
  • 66.03 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011413 30
  • 66.54 (n)
Worm
(Caenorhabditis elegans)
 Secernentea ccf-1 30 31
  • 54.99 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes POP2 31
  • 24 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G10960 30
  • 55.39 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 72 (a)
 OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes caf1 30
  • 59.25 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU09001 30
  • 57.01 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.13234 30
Species where no ortholog for CNOT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CNOT7 Gene

ENSEMBL:
Gene Tree for CNOT7 (if available)
TreeFam:
Gene Tree for CNOT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNOT7: view image

Paralogs for CNOT7 Gene

Paralogs for CNOT7 Gene

(1) SIMAP similar genes for CNOT7 Gene using alignment to 7 proteins:

  • CNOT7_HUMAN
  • E5RGA8_HUMAN
  • E5RGH2_HUMAN
  • E5RHV9_HUMAN
  • E5RJE0_HUMAN
  • H0YAV9_HUMAN
  • H0YBT3_HUMAN

Pseudogenes.org Pseudogenes for CNOT7 Gene

genes like me logo Genes that share paralogs with CNOT7: view

Variants for CNOT7 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNOT7 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
671125 Benign: not provided 17,246,679(-) G/A FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for CNOT7 Gene

Structural Variations from Database of Genomic Variants (DGV) for CNOT7 Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV gain 17160897
nsv981916 CNV duplication 23825009

Variation tolerance for CNOT7 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT7 Gene

Disorders for CNOT7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CNOT7 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CNOT7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CNOT7

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CNOT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT7 Gene

Publications for CNOT7 Gene

  1. hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PMID: 17264152) Robin-Lespinasse Y … Le Romancer M (Journal of cell science 2007) 2 3 23
  2. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PMID: 9820826) Bogdan JA … Dicker IB (The Biochemical journal 1998) 3 4 23
  3. ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. (PMID: 25106868) Adachi S … Natsume T (Nucleic acids research 2014) 3 4
  4. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. (PMID: 23236473) Doidge R … Winkler GS (PloS one 2012) 3 4
  5. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. (PMID: 22977175) Petit AP … Weichenrieder O (Nucleic acids research 2012) 3 4

ExternalLinks

View latest publications for CNOT7 gene in Mastermind

Products for CNOT7 Gene

  • Addgene plasmids for CNOT7
  • Signalway Proteins for CNOT7

Sources for CNOT7 Gene