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Aliases for CNOT7 Gene

Aliases for CNOT7 Gene

  • CCR4-NOT Transcription Complex Subunit 7 2 3 3 5
  • CCR4-Associated Factor 1 3 4
  • BTG1-Binding Factor 1 3 4
  • CAF-1 3 4
  • Caf1a 3 4
  • CAF1 3 4
  • Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 1 3
  • CCR4-NOT Transcription Complex, Subunit 7 2
  • BTG1 Binding Factor 1 2
  • EC 3.1.13.4 4
  • HCAF-1 3

External Ids for CNOT7 Gene

Previous HGNC Symbols for CNOT7 Gene

  • CAF1

Previous GeneCards Identifiers for CNOT7 Gene

  • GC08M016980
  • GC08M017166
  • GC08M017097
  • GC08M017131
  • GC08M017086
  • GC08M015631

Summaries for CNOT7 Gene

Entrez Gene Summary for CNOT7 Gene

  • The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

GeneCards Summary for CNOT7 Gene

CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.

UniProtKB/Swiss-Prot for CNOT7 Gene

  • Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Wiki entry for CNOT7 Gene

Additional gene information for CNOT7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT7 Gene

Genomics for CNOT7 Gene

GeneHancer (GH) Regulatory Elements for CNOT7 Gene

Promoters and enhancers for CNOT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J017245 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.5 -0.2 -218 3.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CNOT7 VPS37A ZDHHC2 LOC102724838
GH08J017494 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 42.3 -250.3 -250304 4.9 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF213 FOS SP5 ENSG00000280453 SLC7A2 LOC100133073 CNOT7 ENSG00000249258 MICU3 MTUS1 NAT2 ENSG00000279271 GC08M017429
GH08J017798 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 15.5 -554.9 -554893 5.6 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YY1 FOS PAF1 SP3 MTUS1 ENSG00000253944 LOC101930275 GC08M017804 GC08M017803 GC08M017802 GC08M017800 ENSG00000253671 CNOT7
GH08J018081 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -836.9 -836937 4.7 CLOCK MLX DMAP1 YBX1 YY1 ZNF143 SP3 GLIS1 NBN NR2C1 ASAH1 ENSG00000245281 LOC101929066 CNOT7 MTUS1 PCM1
GH08J016831 Enhancer 1 Ensembl ENCODE 15.5 +414.7 414656 1.1 CTCF MAX CEBPG ZNF2 RAD21 RFX5 YY1 TEAD3 GTF3C2 POLR3A CNOT7 ZDHHC2 GC08M016797 RN7SL474P ENSG00000253496 LOC105379297
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNOT7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNOT7 gene promoter:

Genomic Locations for CNOT7 Gene

Genomic Locations for CNOT7 Gene
chr8:17,224,964-17,246,878
(GRCh38/hg38)
Size:
21,915 bases
Orientation:
Minus strand
chr8:17,086,737-17,104,387
(GRCh37/hg19)

Genomic View for CNOT7 Gene

Genes around CNOT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT7 Gene

Proteins for CNOT7 Gene

  • Protein details for CNOT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIV1-CNOT7_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 7
    Protein Accession:
    Q9UIV1
    Secondary Accessions:
    • A8MZM5
    • B3KMP1
    • B3KN35
    • D3DSP6
    • G3V108
    • Q7Z530

    Protein attributes for CNOT7 Gene

    Size:
    285 amino acids
    Molecular mass:
    32745 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:19558367). In the complex, interacts directly with CNOT1 (PubMed:21336257). Interacts with AGO2 (By similarity). Interacts with TOB1; recruited by TOB1 to a ternary complex with CPEB3 which is required for mRNA deadenylation and decay (PubMed:21336257, PubMed:23236473, PubMed:19276069). Interacts with BTG1 (By similarity). Interacts with BTG2 (PubMed:23236473). Interacts with NANOS2 (By similarity). Interacts with ZFP36, ZFP36L1 and ZFP36L2; these interactions are inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868).
    SequenceCaution:
    • Sequence=AAF01500.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT7 Gene

    Alternative splice isoforms for CNOT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT7 Gene

Post-translational modifications for CNOT7 Gene

  • Ubiquitination at posLast=240240, Lys206, and posLast=3333
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNOT7 Gene

Domains & Families for CNOT7 Gene

Gene Families for CNOT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CNOT7 Gene

Suggested Antigen Peptide Sequences for CNOT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIV1

UniProtKB/Swiss-Prot:

CNOT7_HUMAN :
  • Belongs to the CAF1 family.
Family:
  • Belongs to the CAF1 family.
genes like me logo Genes that share domains with CNOT7: view

Function for CNOT7 Gene

Molecular function for CNOT7 Gene

UniProtKB/Swiss-Prot Function:
Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.

Enzyme Numbers (IUBMB) for CNOT7 Gene

Gene Ontology (GO) - Molecular Function for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 15769875
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP 23386060
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 9820826
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with CNOT7: view
genes like me logo Genes that share phenotypes with CNOT7: view

Animal Models for CNOT7 Gene

MGI Knock Outs for CNOT7:

Animal Model Products

Clone Products

  • Addgene plasmids for CNOT7

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT7 Gene

Localization for CNOT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT7 Gene

Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT7 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA,ISS --
GO:0005634 nucleus IEA,IDA 9820826
GO:0005737 cytoplasm IMP 23386060
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CNOT7: view

Pathways & Interactions for CNOT7 Gene

genes like me logo Genes that share pathways with CNOT7: view

Pathways by source for CNOT7 Gene

Gene Ontology (GO) - Biological Process for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 23386060
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0005975 carbohydrate metabolic process TAS 9820826
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CNOT7: view

No data available for SIGNOR curated interactions for CNOT7 Gene

Drugs & Compounds for CNOT7 Gene

(1) Additional Compounds for CNOT7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CNOT7: view

Transcripts for CNOT7 Gene

Unigene Clusters for CNOT7 Gene

CCR4-NOT transcription complex, subunit 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for CNOT7

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13:

ExUns: 12c ^ 13a · 13b ^ 14
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CNOT7 Gene

GeneLoc Exon Structure for
CNOT7
ECgene alternative splicing isoforms for
CNOT7

Expression for CNOT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNOT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT7 Gene

This gene is overexpressed in Bone (22.6) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNOT7 Gene



Protein tissue co-expression partners for CNOT7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT7 Gene:

CNOT7

SOURCE GeneReport for Unigene cluster for CNOT7 Gene:

Hs.645009

Evidence on tissue expression from TISSUES for CNOT7 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CNOT7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT7 Gene

Orthologs for CNOT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT7 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT7 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT7 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT7 34 33
  • 96.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT7 34 33
  • 96.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot7 16 34 33
  • 93.1 (n)
rat
(Rattus norvegicus)
Mammalia Cnot7 33
  • 92.87 (n)
chicken
(Gallus gallus)
Aves CNOT7 34 33
  • 88.3 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT7 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot7 33
  • 82.57 (n)
zebrafish
(Danio rerio)
Actinopterygii cnot7 34 33
  • 80.87 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5684 35
  • 75 (a)
Pop2 34 33
  • 66.03 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011413 33
  • 66.54 (n)
worm
(Caenorhabditis elegans)
Secernentea ccf-1 34 33
  • 54.99 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POP2 34
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10960 33
  • 55.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 72 (a)
OneToMany
Cin.13234 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes caf1 33
  • 59.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09001 33
  • 57.01 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13234 33
Species where no ortholog for CNOT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT7 Gene

ENSEMBL:
Gene Tree for CNOT7 (if available)
TreeFam:
Gene Tree for CNOT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNOT7: view image

Paralogs for CNOT7 Gene

Paralogs for CNOT7 Gene

(1) SIMAP similar genes for CNOT7 Gene using alignment to 7 proteins:

  • CNOT7_HUMAN
  • E5RGA8_HUMAN
  • E5RGH2_HUMAN
  • E5RHV9_HUMAN
  • E5RJE0_HUMAN
  • H0YAV9_HUMAN
  • H0YBT3_HUMAN

Pseudogenes.org Pseudogenes for CNOT7 Gene

genes like me logo Genes that share paralogs with CNOT7: view

Variants for CNOT7 Gene

Sequence variations from dbSNP and Humsavar for CNOT7 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs59276128 conflicting-interpretations-of-pathogenicity, not specified 17,247,226(-) G/A/T upstream_transcript_variant
rs1000024559 -- 17,245,390(-) A/T intron_variant
rs1000124923 -- 17,240,681(-) A/G intron_variant
rs1000135745 -- 17,248,735(-) G/A upstream_transcript_variant
rs1000303513 -- 17,234,354(-) ACA/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT7 Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV gain 17160897
nsv981916 CNV duplication 23825009

Variation tolerance for CNOT7 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT7 Gene

Disorders for CNOT7 Gene

Additional Disease Information for CNOT7

No disorders were found for CNOT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT7 Gene

Publications for CNOT7 Gene

  1. hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PMID: 17264152) Robin-Lespinasse Y … Le Romancer M (Journal of cell science 2007) 2 3 22 58
  2. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PMID: 9820826) Bogdan JA … Dicker IB (The Biochemical journal 1998) 3 4 22 58
  3. ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. (PMID: 25106868) Adachi S … Natsume T (Nucleic acids research 2014) 3 4 58
  4. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. (PMID: 22977175) Petit AP … Weichenrieder O (Nucleic acids research 2012) 3 4 58
  5. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. (PMID: 23236473) Doidge R … Winkler GS (PloS one 2012) 3 4 58

Products for CNOT7 Gene

  • Addgene plasmids for CNOT7

Sources for CNOT7 Gene

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