Aliases for CNOT6L Gene

Aliases for CNOT6L Gene

  • CCR4-NOT Transcription Complex Subunit 6 Like 2 3 5
  • Carbon Catabolite Repressor Protein 4 Homolog B 3 4
  • CCR4-NOT Transcription Complex Subunit 6-Like 3 4
  • CCR4-NOT Transcription Complex, Subunit 6-Like 2
  • DKFZp434K098 2
  • EC 3.1.13.4 4
  • CNOT6L 5
  • CCR4b 3
  • Ccr4b 2
  • CCR4B 4

External Ids for CNOT6L Gene

Previous GeneCards Identifiers for CNOT6L Gene

  • GC04M078548
  • GC04M078828
  • GC04M079030
  • GC04M079096
  • GC04M078995
  • GC04M078853
  • GC04M078634
  • GC04M074386

Summaries for CNOT6L Gene

GeneCards Summary for CNOT6L Gene

CNOT6L (CCR4-NOT Transcription Complex Subunit 6 Like) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6.

UniProtKB/Swiss-Prot Summary for CNOT6L Gene

  • Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.

Additional gene information for CNOT6L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNOT6L Gene

Genomics for CNOT6L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CNOT6L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNOT6L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNOT6L

Top Transcription factor binding sites by QIAGEN in the CNOT6L gene promoter:
  • aMEF-2
  • ATF-2
  • c-Jun
  • c-Myb
  • Evi-1
  • FOXO1
  • FOXO1a
  • MEF-2A
  • Pax-5
  • XBP-1

Genomic Locations for CNOT6L Gene

Genomic Locations for CNOT6L Gene
chr4:77,713,387-77,820,269
(GRCh38/hg38)
Size:
106,883 bases
Orientation:
Minus strand
chr4:78,634,541-78,740,769
(GRCh37/hg19)
Size:
106,229 bases
Orientation:
Minus strand

Genomic View for CNOT6L Gene

Genes around CNOT6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT6L Gene

Proteins for CNOT6L Gene

  • Protein details for CNOT6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LI5-CNO6L_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 6-like
    Protein Accession:
    Q96LI5
    Secondary Accessions:
    • Q9UF92

    Protein attributes for CNOT6L Gene

    Size:
    555 amino acids
    Molecular mass:
    63001 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:17452450, PubMed:18377426, PubMed:19558367). Interacts with CNOT1, CNOT3, CNOT7, CNOT8 and CNOT9 (PubMed:17452450). Interacts with TOB1 (PubMed:18377426). Interacts with NANOS2 (By similarity). Interacts with ZFP36 (By similarity).
    Miscellaneous:
    • Depletion of CNOT6L causes cell growth defect.

    Three dimensional structures from OCA and Proteopedia for CNOT6L Gene

    Alternative splice isoforms for CNOT6L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT6L Gene

Post-translational modifications for CNOT6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CNOT6L Gene

Domains & Families for CNOT6L Gene

Gene Families for CNOT6L Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CNOT6L Gene

GenScript: Design optimal peptide antigens:
  • Carbon catabolite repressor protein 4 homolog B (CNO6L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LI5

UniProtKB/Swiss-Prot:

CNO6L_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with CNOT6L: view

Function for CNOT6L Gene

Molecular function for CNOT6L Gene

UniProtKB/Swiss-Prot Function:
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:18377426, ECO:0000269|PubMed:27013054};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by free AMP, and with lesser efficiency also by CMP, GMP, UMP, ATP and neomycin.

Enzyme Numbers (IUBMB) for CNOT6L Gene

Phenotypes From GWAS Catalog for CNOT6L Gene

Gene Ontology (GO) - Molecular Function for CNOT6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IBA 21873635
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0004535 poly(A)-specific ribonuclease activity TAS --
GO:0005515 protein binding IPI 17452450
genes like me logo Genes that share ontologies with CNOT6L: view
genes like me logo Genes that share phenotypes with CNOT6L: view

Animal Models for CNOT6L Gene

MGI Knock Outs for CNOT6L:

Animal Model Products

CRISPR Products

miRNA for CNOT6L Gene

miRTarBase miRNAs that target CNOT6L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNOT6L

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT6L Gene

Localization for CNOT6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT6L Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. {ECO:0000269 PubMed:21233283}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT6L gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNOT6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21233283
GO:0005737 cytoplasm IBA,IDA 21233283
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IBA,IDA 19558367
genes like me logo Genes that share ontologies with CNOT6L: view

Pathways & Interactions for CNOT6L Gene

genes like me logo Genes that share pathways with CNOT6L: view

Gene Ontology (GO) - Biological Process for CNOT6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IBA,TAS --
GO:0006397 mRNA processing IEA --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CNOT6L: view

No data available for SIGNOR curated interactions for CNOT6L Gene

Drugs & Compounds for CNOT6L Gene

No Compound Related Data Available

Transcripts for CNOT6L Gene

mRNA/cDNA for CNOT6L Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNOT6L

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - - -

Relevant External Links for CNOT6L Gene

GeneLoc Exon Structure for
CNOT6L

Expression for CNOT6L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNOT6L Gene

Protein differential expression in normal tissues from HIPED for CNOT6L Gene

This gene is overexpressed in CD4 Tcells (26.3), Monocytes (19.9), and CD8 Tcells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNOT6L Gene



Protein tissue co-expression partners for CNOT6L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNOT6L

SOURCE GeneReport for Unigene cluster for CNOT6L Gene:

Hs.592519

mRNA Expression by UniProt/SwissProt for CNOT6L Gene:

Q96LI5-CNO6L_HUMAN
Tissue specificity: Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus.

Evidence on tissue expression from TISSUES for CNOT6L Gene

  • Nervous system(3.6)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CNOT6L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT6L Gene

Orthologs for CNOT6L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNOT6L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CNOT6L 30 31
  • 99.88 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CNOT6L 30 31
  • 98.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CNOT6L 30 31
  • 98.48 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CNOT6L 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cnot6l 30 17 31
  • 96.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cnot6l 30
  • 96.06 (n)
Oppossum
(Monodelphis domestica)
Mammalia CNOT6L 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CNOT6L 30 31
  • 89.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CNOT6L 31
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cnot6l 30
  • 84.07 (n)
Str.16965 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.34621 30
Zebrafish
(Danio rerio)
Actinopterygii cnot6l 30 31
  • 74.57 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004405 30
  • 59.83 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta twin 30 31
  • 58.85 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ccr-4 30 31
  • 56.69 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR288W 30
  • 48.99 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 30 31
  • 48.46 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15884g 30
  • 48.01 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ccr4 30
  • 52.63 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU07779 30
  • 48.43 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToMany
Species where no ortholog for CNOT6L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CNOT6L Gene

ENSEMBL:
Gene Tree for CNOT6L (if available)
TreeFam:
Gene Tree for CNOT6L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNOT6L: view image

Paralogs for CNOT6L Gene

Paralogs for CNOT6L Gene

(2) SIMAP similar genes for CNOT6L Gene using alignment to 6 proteins:

  • CNO6L_HUMAN
  • D6RGK9_HUMAN
  • D6RIW9_HUMAN
  • H0Y9C1_HUMAN
  • H0Y9Z5_HUMAN
  • H0YA76_HUMAN

Pseudogenes.org Pseudogenes for CNOT6L Gene

genes like me logo Genes that share paralogs with CNOT6L: view

Variants for CNOT6L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNOT6L Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
747869 Likely Benign: not provided 77,726,202(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CNOT6L Gene

Structural Variations from Database of Genomic Variants (DGV) for CNOT6L Gene

Variant ID Type Subtype PubMed ID
esv23755 CNV loss 19812545
esv2752050 CNV gain 17911159
esv3601083 CNV loss 21293372
nsv472728 CNV novel sequence insertion 20440878
nsv518757 CNV loss 19592680
nsv594700 CNV loss 21841781
nsv594701 CNV loss 21841781
nsv594702 CNV gain 21841781
nsv594703 CNV gain 21841781
nsv7363 OTHER inversion 18451855
nsv829976 CNV gain 17160897
nsv966286 CNV duplication 23825009

Variation tolerance for CNOT6L Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT6L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT6L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT6L Gene

Disorders for CNOT6L Gene

Additional Disease Information for CNOT6L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CNOT6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT6L Gene

Publications for CNOT6L Gene

  1. Structural basis for inhibition of the deadenylase activity of human CNOT6L. (PMID: 27013054) Zhang Q … Bartlam M (FEBS letters 2016) 3 4
  2. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. (PMID: 21233283) Mittal S … Winkler GS (Molecular biology of the cell 2011) 3 4
  3. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. (PMID: 20628353) Wang H … Rao Z (The EMBO journal 2010) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. A Bayesian approach to genetic association studies with family-based designs. (PMID: 20818722) Naylor MG … Lange C (Genetic epidemiology 2010) 3 41

Products for CNOT6L Gene

Sources for CNOT6L Gene