Aliases for CNOT4 Gene
External Ids for CNOT4 Gene
Previous HGNC Symbols for CNOT4 Gene
Previous GeneCards Identifiers for CNOT4 Gene
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
GeneCards Summary for CNOT4 Gene
CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot Summary for CNOT4 Gene
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).