Aliases for CNOT2 Gene
External Ids for CNOT2 Gene
Previous HGNC Symbols for CNOT2 Gene
Previous GeneCards Identifiers for CNOT2 Gene
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for CNOT2 Gene
CNOT2 (CCR4-NOT Transcription Complex Subunit 2) is a Protein Coding gene. Diseases associated with CNOT2 include Intellectual Developmental Disorder With Nasal Speech, Dysmorphic Facies, And Variable Skeletal Anomalies and 12Q15q21.1 Microdeletion Syndrome. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription corepressor binding. An important paralog of this gene is CNOT3.
UniProtKB/Swiss-Prot Summary for CNOT2 Gene
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.