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Aliases for CNOT2 Gene

Aliases for CNOT2 Gene

  • CCR4-NOT Transcription Complex Subunit 2 2 3 5
  • CCR4-Associated Factor 2 3 4
  • CDC36 3 4
  • NOT2 3 4
  • CCR4-NOT Transcription Complex, Subunit 2 2
  • Negative Regulator Of Transcription 2 3
  • HSPC131 3
  • NOT2H 3

External Ids for CNOT2 Gene

Previous HGNC Symbols for CNOT2 Gene

  • NOT2

Previous GeneCards Identifiers for CNOT2 Gene

  • GC12P070508
  • GC12P070353
  • GC12P068923
  • GC12P070636
  • GC12P067686

Summaries for CNOT2 Gene

Entrez Gene Summary for CNOT2 Gene

  • This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CNOT2 Gene

CNOT2 (CCR4-NOT Transcription Complex Subunit 2) is a Protein Coding gene. Diseases associated with CNOT2 include Squamous Cell Papilloma. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription cofactor activity and RNA polymerase II transcription corepressor binding.

UniProtKB/Swiss-Prot for CNOT2 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT2 Gene

Additional gene information for CNOT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT2 Gene

Genomics for CNOT2 Gene

GeneHancer (GH) Regulatory Elements for CNOT2 Gene

Promoters and enhancers for CNOT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I070241 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.9 +0.5 539 3.9 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 CNOT2 ENSG00000257815 LINC01481 KCNMB4 FRS2 LOC105369826 ENSG00000279530
GH12I070660 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 45.2 +418.5 418520 2.6 SMAD1 ATF1 ZFP64 POLR2B ZNF766 CBX5 GATA2 ATF7 CAVIN1 NCOA1 CNOT2 PTPRB LINC01481 FAHD2P1 PTPRR
GH12I069358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.3 -883.0 -882992 2.2 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YEATS4 LYZ NUP107 CNOT2 KRT8P39 RAP1B RPL10P12 CPSF6 RN7SL804P
GH12I069328 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -911.5 -911485 6.1 HDGF FOXA2 MLX ARID4B FEZF1 YY1 ZNF766 ZNF548 PAF1 SP5 ENSG00000274979 LYZ NUP107 YEATS4 CNOT2 CPSF6 KRT8P39 CPM GC12M069304
GH12I070365 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.1 +123.6 123637 2.7 PKNOX1 CLOCK ZNF133 SIN3A GLI4 ZNF2 ZNF48 GLIS2 ZNF143 KLF7 KCNMB4 FRS2 CNOT2 ENSG00000257815 LINC02373 GC12P070431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNOT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNOT2 gene promoter:

Genomic Locations for CNOT2 Gene

Genomic Locations for CNOT2 Gene
chr12:70,242,994-70,354,993
(GRCh38/hg38)
Size:
112,000 bases
Orientation:
Plus strand
chr12:70,636,774-70,748,773
(GRCh37/hg19)

Genomic View for CNOT2 Gene

Genes around CNOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT2 Gene

Proteins for CNOT2 Gene

  • Protein details for CNOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZN8-CNOT2_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 2
    Protein Accession:
    Q9NZN8
    Secondary Accessions:
    • Q9H3E0
    • Q9NSX5
    • Q9NWR6
    • Q9P028

    Protein attributes for CNOT2 Gene

    Size:
    540 amino acids
    Molecular mass:
    59738 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.
    SequenceCaution:
    • Sequence=AAF29095.1; Type=Frameshift; Positions=474; Evidence={ECO:0000305}; Sequence=AAQ13426.1; Type=Frameshift; Positions=71, 76, 84, 98, 123, 370, 384, 393; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT2 Gene

    Alternative splice isoforms for CNOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT2 Gene

Post-translational modifications for CNOT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CNOT2 Gene

Domains & Families for CNOT2 Gene

Gene Families for CNOT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNOT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZN8

UniProtKB/Swiss-Prot:

CNOT2_HUMAN :
  • Belongs to the CNOT2/3/5 family.
Family:
  • Belongs to the CNOT2/3/5 family.
genes like me logo Genes that share domains with CNOT2: view

Function for CNOT2 Gene

Molecular function for CNOT2 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Phenotypes From GWAS Catalog for CNOT2 Gene

Gene Ontology (GO) - Molecular Function for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity TAS 10637334
GO:0001226 RNA polymerase II transcription corepressor binding IDA 16712523
GO:0004535 contributes_to poly(A)-specific ribonuclease activity IMP 21299754
GO:0005515 protein binding IPI 10637334
genes like me logo Genes that share ontologies with CNOT2: view
genes like me logo Genes that share phenotypes with CNOT2: view

Animal Model Products

Clone Products

  • Addgene plasmids for CNOT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT2 Gene

Localization for CNOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA --
GO:0005634 nucleus NAS,IDA 10637334
GO:0005737 cytoplasm IDA,IEA 21299754
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CNOT2: view

Pathways & Interactions for CNOT2 Gene

genes like me logo Genes that share pathways with CNOT2: view

Gene Ontology (GO) - Biological Process for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 14707134
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CNOT2: view

No data available for SIGNOR curated interactions for CNOT2 Gene

Drugs & Compounds for CNOT2 Gene

No Compound Related Data Available

Transcripts for CNOT2 Gene

Unigene Clusters for CNOT2 Gene

CCR4-NOT transcription complex, subunit 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for CNOT2

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for CNOT2 Gene

GeneLoc Exon Structure for
CNOT2
ECgene alternative splicing isoforms for
CNOT2

Expression for CNOT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNOT2 Gene

Protein differential expression in normal tissues from HIPED for CNOT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.0), Testis (9.4), and Bone (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT2 Gene



Protein tissue co-expression partners for CNOT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT2 Gene:

CNOT2

SOURCE GeneReport for Unigene cluster for CNOT2 Gene:

Hs.133350

mRNA Expression by UniProt/SwissProt for CNOT2 Gene:

Q9NZN8-CNOT2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CNOT2 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Heart(4.4)
  • Liver(4.4)
  • Skin(4.4)
  • Pancreas(2.8)
  • Intestine(2.2)
  • Muscle(2.2)
  • Lung(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CNOT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT2 Gene

Orthologs for CNOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CNOT2 33 34
  • 98.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT2 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT2 34
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNOT2 33 34
  • 96.9 (n)
oppossum
(Monodelphis domestica)
Mammalia CNOT2 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot2 33 16 34
  • 95.43 (n)
rat
(Rattus norvegicus)
Mammalia Cnot2 33
  • 95.25 (n)
chicken
(Gallus gallus)
Aves CNOT2 33 34
  • 93.72 (n)
lizard
(Anolis carolinensis)
Reptilia CNOT2 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot2 33
  • 88.46 (n)
Str.5823 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13312 33
zebrafish
(Danio rerio)
Actinopterygii cnot2 33 34
  • 79.05 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13407 33
fruit fly
(Drosophila melanogaster)
Insecta Rga 35 34
  • 54 (a)
CG6576 34
  • 27 (a)
OneToMany
CG15262 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ntl-2 33 34
  • 49.41 (n)
B0286.4c 35
  • 47 (a)
B0286.4b 35
  • 45 (a)
B0286.4a 35
  • 43 (a)
tag-153 34
  • 16 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12408g 33
  • 47.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC36 33 34 36
  • 46.79 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL151C 33
  • 44.98 (n)
rice
(Oryza sativa)
Liliopsida Os.11862 33
corn
(Zea mays)
Liliopsida Zm.3513 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8562 34
  • 76 (a)
OneToMany
CSA.8375 34
  • 29 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes not2 33
  • 46.13 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2536 33
Species where no ortholog for CNOT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT2 Gene

ENSEMBL:
Gene Tree for CNOT2 (if available)
TreeFam:
Gene Tree for CNOT2 (if available)

Paralogs for CNOT2 Gene

genes like me logo Genes that share paralogs with CNOT2: view

No data available for Paralogs for CNOT2 Gene

Variants for CNOT2 Gene

Sequence variations from dbSNP and Humsavar for CNOT2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000031984 -- 70,250,121(+) T/C intron_variant
rs1000046330 -- 70,346,189(+) T/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000063298 -- 70,255,860(+) T/C intron_variant
rs1000123015 -- 70,286,510(+) C/T intron_variant
rs1000153966 -- 70,286,121(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT2 Gene

Variant ID Type Subtype PubMed ID
dgv2687n54 CNV loss 21841781
dgv2688n54 CNV loss 21841781
dgv2689n54 CNV loss 21841781
dgv292n67 CNV loss 20364138
esv1061540 CNV insertion 17803354
esv25808 CNV loss 19812545
esv3394750 CNV insertion 20981092
esv3629884 CNV gain 21293372
esv3629885 CNV loss 21293372
nsv1048888 CNV loss 25217958
nsv1140290 OTHER inversion 24896259
nsv1142724 CNV deletion 24896259
nsv1144634 CNV deletion 24896259
nsv475843 CNV novel sequence insertion 20440878
nsv559254 CNV loss 21841781
nsv559256 CNV loss 21841781
nsv559257 CNV loss 21841781
nsv826415 CNV loss 20364138

Variation tolerance for CNOT2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT2 Gene

Disorders for CNOT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNOT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
squamous cell papilloma
  • epidermoid papilloma
- elite association - COSMIC cancer census association via MalaCards
Search CNOT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CNOT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CNOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT2 Gene

Publications for CNOT2 Gene

  1. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. (PMID: 16712523) Jayne S … Timmers HT (The Biochemical journal 2006) 3 4 22 58
  2. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert TK … Timmers HT (Nucleic acids research 2000) 2 3 4 58
  3. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. (PMID: 22367759) Zheng X … Hu G (Stem cells (Dayton, Ohio) 2012) 3 4 58
  4. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. (PMID: 21299754) Ito K … Yamamoto T (Genes to cells : devoted to molecular & cellular mechanisms 2011) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CNOT2 Gene

  • Addgene plasmids for CNOT2

Sources for CNOT2 Gene

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