CNOT11 Gene (Protein Coding)

CCR4-NOT Transcription Complex Subunit 11

GC02P101252
GIFtS:
30
See more...

Aliases for CNOT11 Gene

Aliases for CNOT11 Gene

  • CCR4-NOT Transcription Complex Subunit 11 2 3 4 5
  • C2orf29 3 4
  • C40 2 3
  • CCR4-NOT Transcription Complex, Subunit 11 2
  • Chromosome 2 Open Reading Frame 29 2
  • UPF0760 Protein C2orf29 3
  • CNOT11 5

External Ids for CNOT11 Gene

Previous HGNC Symbols for CNOT11 Gene

  • C2orf29

Previous GeneCards Identifiers for CNOT11 Gene

  • GC02P101870

Summaries for CNOT11 Gene

GeneCards Summary for CNOT11 Gene

CNOT11 (CCR4-NOT Transcription Complex Subunit 11) is a Protein Coding gene. Diseases associated with CNOT11 include Wissler-Fanconi Syndrome and Fungal Esophagitis. Among its related pathways are Deadenylation-dependent mRNA decay and TP53 Regulates Transcription of Cell Cycle Genes.

UniProtKB/Swiss-Prot Summary for CNOT11 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

Additional gene information for CNOT11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNOT11 Gene

Genomics for CNOT11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CNOT11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNOT11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNOT11

Genomic Locations for CNOT11 Gene

Latest Assembly
chr2:101,252,886-101,270,316
(GRCh38/hg38)
Size:
17,431 bases
Orientation:
Plus strand

Previous Assembly
chr2:101,869,348-101,886,778
(GRCh37/hg19 by Entrez Gene)
Size:
17,431 bases
Orientation:
Plus strand

chr2:101,869,264-101,886,778
(GRCh37/hg19 by Ensembl)
Size:
17,515 bases
Orientation:
Plus strand

Genomic View for CNOT11 Gene

Genes around CNOT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CNOT11 Gene

Proteins for CNOT11 Gene

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  3. Assay products for research

  • Protein details for CNOT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKZ1-CNO11_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 11
    Protein Accession:
    Q9UKZ1
    Secondary Accessions:
    • Q6P2M9
    • Q8N681

    Protein attributes for CNOT11 Gene

    Size:
    510 amino acids
    Molecular mass:
    55215 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.

neXtProt entry for CNOT11 Gene

Protein Expression for CNOT11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CNOT11 Gene

  • Ubiquitination at Lys335 and Lys495
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Biorbyt antibodies for CNOT11

No data available for DME Specific Peptides for CNOT11 Gene

Domains & Families for CNOT11 Gene

Gene Families for CNOT11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNOT11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT11 Gene

GenScript: Design optimal peptide antigens:
  • UPF0760 protein C2orf29 (CB029_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKZ1

UniProtKB/Swiss-Prot:

CNO11_HUMAN :
  • Belongs to the CNOT11 family.
Family:
  • Belongs to the CNOT11 family.
genes like me logo Genes that share domains with CNOT11: view

Function for CNOT11 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for CNOT11 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

Phenotypes From GWAS Catalog for CNOT11 Gene

Gene Ontology (GO) - Molecular Function for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23232451
genes like me logo Genes that share ontologies with CNOT11: view
genes like me logo Genes that share phenotypes with CNOT11: view

Animal Models for research

miRNA for CNOT11 Gene

miRTarBase miRNAs that target CNOT11

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNOT11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT11 Gene

Localization for CNOT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT11 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IEA,IDA 19558367
genes like me logo Genes that share ontologies with CNOT11: view

Pathways & Interactions for CNOT11 Gene

genes like me logo Genes that share pathways with CNOT11: view

Gene Ontology (GO) - Biological Process for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with CNOT11: view

No data available for SIGNOR curated interactions for CNOT11 Gene

Drugs & Compounds for CNOT11 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for CNOT11 Gene

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mRNA/cDNA for CNOT11 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNOT11

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for CNOT11 Gene

GeneLoc Exon Structure for
CNOT11

Expression for CNOT11 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNOT11 Gene

mRNA expression in normal human tissues for CNOT11 Gene
mRNA expression by GTEx for CNOT11 Gene

Protein differential expression in normal tissues from HIPED for CNOT11 Gene

This gene is overexpressed in Pancreatic juice (8.4) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNOT11 Gene



Protein tissue co-expression partners for CNOT11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNOT11

SOURCE GeneReport for Unigene cluster for CNOT11 Gene:

Hs.744080

Evidence on tissue expression from TISSUES for CNOT11 Gene

  • Nervous system(4.4)
  • Intestine(4.4)
  • Kidney(2.3)
  • Heart(2.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with CNOT11: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT11 Gene

Orthologs for CNOT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CNOT11 30 31
  • 99.61 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CNOT11 31
  • 95 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CNOT11 31
  • 92 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CNOT11 30 31
  • 91.37 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cnot11 30 17 31
  • 88.05 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CNOT11 30 31
  • 87.32 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cnot11 30
  • 86.11 (n)
Chicken
(Gallus gallus)
 Aves CNOT11 31
  • 96 (a)
 OneToOne
C2ORF29 30
  • 83.11 (n)
Lizard
(Anolis carolinensis)
 Reptilia CNOT11 31
  • 94 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cnot11 30
  • 78.48 (n)
Str.18681 30
Zebrafish
(Danio rerio)
 Actinopterygii cnot11 30 31
  • 72.88 (n)
 OneToOne
wufj49e01 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.971 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG13567 30 31
  • 59.38 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007117 30
  • 49.52 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G18420 30
  • 51.11 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.5129 30
Soybean
(Glycine max)
 eudicotyledons Gma.17966 30
Rice
(Oryza sativa)
 Liliopsida Os11g0240900 30
  • 54.35 (n)
Barley
(Hordeum vulgare)
 Liliopsida Hv.10531 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.4129 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.605 31
  • 60 (a)
 OneToMany
-- 31
  • 54 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.12100 30
Species where no ortholog for CNOT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Worm (Caenorhabditis elegans)

Evolution for CNOT11 Gene

ENSEMBL:
Gene Tree for CNOT11 (if available)
TreeFam:
Gene Tree for CNOT11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNOT11: view image

Paralogs for CNOT11 Gene

No data available for Paralogs for CNOT11 Gene

Variants for CNOT11 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CNOT11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CNOT11 Gene

Variant ID Type Subtype PubMed ID
esv34123 CNV loss 18971310

Variation tolerance for CNOT11 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNOT11 Gene

Disorders for CNOT11 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CNOT11 Gene - From: COP

Disorder Aliases PubMed IDs
wissler-fanconi syndrome
  • wissler's subsepsis allergica
fungal esophagitis
plantar fasciitis
  • fasciitis, plantar
dermatographia
  • dermatographic urticaria
rapidly progressive glomerulonephritis
  • glomerulonephritis rapidly progressive
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CNOT11

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CNOT11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT11 Gene

Publications for CNOT11 Gene

  1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F … Séraphin B (RNA biology 2013) 2 3 4
  2. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P … Izaurralde E (RNA biology 2013) 2 3 4
  3. Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh JJ … Slamon DJ (Nucleic acids research 1999) 2 3 4
  4. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau NC … Timmers HT (The Biochemical journal 2009) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4

ExternalLinks

View latest publications for CNOT11 gene in Mastermind

Products for CNOT11 Gene

  • Biorbyt antibodies for CNOT11

Sources for CNOT11 Gene