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Aliases for CNOT11 Gene

Aliases for CNOT11 Gene

  • CCR4-NOT Transcription Complex Subunit 11 2 3 5
  • C2orf29 3 4
  • CCR4-NOT Transcription Complex, Subunit 11 2
  • Chromosome 2 Open Reading Frame 29 2
  • UPF0760 Protein C2orf29 3
  • C40 3

External Ids for CNOT11 Gene

Previous HGNC Symbols for CNOT11 Gene

  • C2orf29

Previous GeneCards Identifiers for CNOT11 Gene

  • GC02P101870

Summaries for CNOT11 Gene

GeneCards Summary for CNOT11 Gene

CNOT11 (CCR4-NOT Transcription Complex Subunit 11) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay.

UniProtKB/Swiss-Prot for CNOT11 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

Additional gene information for CNOT11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT11 Gene

Genomics for CNOT11 Gene

GeneHancer (GH) Regulatory Elements for CNOT11 Gene

Promoters and enhancers for CNOT11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I101250 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 223 4.1 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B CNOT11 TBC1D8 SNORD89 RNF149 LOC105373511
GH02I100984 Enhancer 0.9 ENCODE 9.8 -267.8 -267758 0.2 HDGF ATF1 ARNT ARID4B YBX1 ZNF2 ZNF48 TCF12 ARID2 ZNF207 RNF149 CNOT11 LOC101927142 PIR60091 NPAS2
GH02I100779 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -471.6 -471613 2.8 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 SLC30A9 ZNF207 RXRA NPAS2 ENSG00000232034 LOC101927142 CNOT11 LOC105373508
GH02I101236 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -13.7 -13706 4.3 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 PAF1 MIER2 REST PPARG SNORD89 RNF149 CNOT11 TBC1D8 TBC1D8-AS1
GH02I101245 Enhancer 0.9 ENCODE dbSUPER 0.4 -6.7 -6741 1.6 DRAP1 SAP130 ARID4B DMAP1 ZNF644 ZNF48 RARA ZKSCAN1 TEAD3 NR2F6 RNF149 SNORD89 TBC1D8 CNOT11 TBC1D8-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNOT11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CNOT11 Gene

Genomic Locations for CNOT11 Gene
chr2:101,252,802-101,270,316
(GRCh38/hg38)
Size:
17,515 bases
Orientation:
Plus strand
chr2:101,869,264-101,886,778
(GRCh37/hg19)

Genomic View for CNOT11 Gene

Genes around CNOT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT11 Gene

Proteins for CNOT11 Gene

  • Protein details for CNOT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKZ1-CNO11_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 11
    Protein Accession:
    Q9UKZ1
    Secondary Accessions:
    • Q6P2M9
    • Q8N681

    Protein attributes for CNOT11 Gene

    Size:
    510 amino acids
    Molecular mass:
    55215 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.

neXtProt entry for CNOT11 Gene

Post-translational modifications for CNOT11 Gene

  • Ubiquitination at posLast=335335 and posLast=495495

Other Protein References for CNOT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNOT11 Gene

Domains & Families for CNOT11 Gene

Gene Families for CNOT11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNOT11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKZ1

UniProtKB/Swiss-Prot:

CNO11_HUMAN :
  • Belongs to the CNOT11 family.
Family:
  • Belongs to the CNOT11 family.
genes like me logo Genes that share domains with CNOT11: view

Function for CNOT11 Gene

Molecular function for CNOT11 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

Gene Ontology (GO) - Molecular Function for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23232451
genes like me logo Genes that share ontologies with CNOT11: view
genes like me logo Genes that share phenotypes with CNOT11: view

Animal Model Products

miRNA for CNOT11 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT11 Gene

Localization for CNOT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT11 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IDA,IEA 19558367
genes like me logo Genes that share ontologies with CNOT11: view

Pathways & Interactions for CNOT11 Gene

genes like me logo Genes that share pathways with CNOT11: view

Gene Ontology (GO) - Biological Process for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CNOT11: view

No data available for SIGNOR curated interactions for CNOT11 Gene

Drugs & Compounds for CNOT11 Gene

No Compound Related Data Available

Transcripts for CNOT11 Gene

mRNA/cDNA for CNOT11 Gene

Unigene Clusters for CNOT11 Gene

CCR4-NOT transcription complex, subunit 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for CNOT11 Gene

GeneLoc Exon Structure for
CNOT11
ECgene alternative splicing isoforms for
CNOT11

Expression for CNOT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNOT11 Gene

Protein differential expression in normal tissues from HIPED for CNOT11 Gene

This gene is overexpressed in Pancreatic juice (8.4) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT11 Gene



Protein tissue co-expression partners for CNOT11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT11 Gene:

CNOT11

SOURCE GeneReport for Unigene cluster for CNOT11 Gene:

Hs.744080

Evidence on tissue expression from TISSUES for CNOT11 Gene

  • Intestine(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CNOT11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT11 Gene

Orthologs for CNOT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT11 33 34
  • 99.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT11 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT11 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT11 33 34
  • 91.37 (n)
mouse
(Mus musculus)
Mammalia Cnot11 33 16 34
  • 88.05 (n)
cow
(Bos Taurus)
Mammalia CNOT11 33 34
  • 87.32 (n)
rat
(Rattus norvegicus)
Mammalia Cnot11 33
  • 86.11 (n)
chicken
(Gallus gallus)
Aves CNOT11 34
  • 96 (a)
OneToOne
C2ORF29 33
  • 83.11 (n)
lizard
(Anolis carolinensis)
Reptilia CNOT11 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot11 33
  • 78.48 (n)
Str.18681 33
zebrafish
(Danio rerio)
Actinopterygii cnot11 33 34
  • 72.88 (n)
wufj49e01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.971 33
fruit fly
(Drosophila melanogaster)
Insecta CG13567 33 34
  • 59.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007117 33
  • 49.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18420 33
  • 51.11 (n)
soybean
(Glycine max)
eudicotyledons Gma.17966 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5129 33
rice
(Oryza sativa)
Liliopsida Os11g0240900 33
  • 54.35 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.10531 33
wheat
(Triticum aestivum)
Liliopsida Ta.4129 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.605 34
  • 60 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12100 33
Species where no ortholog for CNOT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CNOT11 Gene

ENSEMBL:
Gene Tree for CNOT11 (if available)
TreeFam:
Gene Tree for CNOT11 (if available)

Paralogs for CNOT11 Gene

No data available for Paralogs for CNOT11 Gene

Variants for CNOT11 Gene

Sequence variations from dbSNP and Humsavar for CNOT11 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000055269 -- 101,255,393(+) G/C intron_variant
rs1000087254 -- 101,265,211(+) G/A intron_variant
rs1000157486 -- 101,260,717(+) T/A intron_variant
rs1000444971 -- 101,252,775(+) A/C/T upstream_transcript_variant
rs1000649038 -- 101,258,343(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT11 Gene

Variant ID Type Subtype PubMed ID
esv34123 CNV loss 18971310

Variation tolerance for CNOT11 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT11 Gene

Disorders for CNOT11 Gene

Additional Disease Information for CNOT11

No disorders were found for CNOT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT11 Gene

Publications for CNOT11 Gene

  1. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P … Izaurralde E (RNA biology 2013) 2 3 4 58
  2. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F … Séraphin B (RNA biology 2013) 2 3 4 58
  3. Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh JJ … Slamon DJ (Nucleic acids research 1999) 2 3 4 58
  4. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau NC … Timmers HT (The Biochemical journal 2009) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for CNOT11 Gene

Sources for CNOT11 Gene

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