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CNOT10 Gene(Protein Coding)

CCR4-NOT Transcription Complex Subunit 10

GCID:
GC03P032727
GIFtS:
42
Genes Participants
UDN Logo

Aliases for CNOT10 Gene

Aliases for CNOT10 Gene

  • CCR4-NOT Transcription Complex Subunit 10 2 3 5
  • CCR4-NOT Transcription Complex, Subunit 10 2

External Ids for CNOT10 Gene

Previous GeneCards Identifiers for CNOT10 Gene

  • GC03P032698
  • GC03P032701

Summaries for CNOT10 Gene

GeneCards Summary for CNOT10 Gene

CNOT10 (CCR4-NOT Transcription Complex Subunit 10) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay.

UniProtKB/Swiss-Prot for CNOT10 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Additional gene information for CNOT10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT10 Gene

Genomics for CNOT10 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CNOT10 Gene

Promoters and enhancers for CNOT10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I032684 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575.5 +0.6 560 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 CNOT10 GLB1 TMPPE UBP1 DYNC1LI1 RPL31P18 CMTM6 ENSG00000236732 TRIM71 PIR58788
GH03I032695 Promoter 0.6 EPDnew 550.4 +10.4 10377 0.1 PPARG CNOT10 CNOT10-AS1 SUGT1P2 RPL31P18 CMTM6 TRIM71 PIR58788
GH03I033437 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 69.7 +754.8 754792 5.5 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC UBP1 PIR40256 CNOT10 PDCD6IP FBXL2 GLB1 TMPPE CMTM6 GC03M033417
GH03I032501 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 32.8 -182.8 -182805 2.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 CMTM6 CNOT10 UBP1 DYNC1LI1 SUGT1P2 CNOT10-AS1 GC03P032466
GH03I033113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.9 +429.6 429562 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CRTAP GC03P033114 CNOT10 PDCD6IP GLB1 UBP1 PIR55934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNOT10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNOT10 gene promoter:

Genomic Locations for CNOT10 Gene

Genomic Locations for CNOT10 Gene
chr3:32,685,145-32,773,875
(GRCh38/hg38)
Size:
88,731 bases
Orientation:
Plus strand
chr3:32,726,637-32,815,367
(GRCh37/hg19)

Genomic View for CNOT10 Gene

Genes around CNOT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CNOT10 Gene

Proteins for CNOT10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CNOT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9A5-CNO10_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 10
    Protein Accession:
    Q9H9A5
    Secondary Accessions:
    • B7Z7L1
    • F8WAF2
    • Q9BU30
    • Q9H5J7
    • Q9H8X1
    • Q9H9W0
    • Q9HAH3
    • Q9UFJ2

    Protein attributes for CNOT10 Gene

    Size:
    744 amino acids
    Molecular mass:
    82310 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.
    SequenceCaution:
    • Sequence=BAB13876.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNOT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT10 Gene

Protein Expression for CNOT10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CNOT10 Gene

  • Ubiquitination at Lys74, posLast=256256, Lys271, and posLast=404404
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNOT10 Gene

Domains & Families for CNOT10 Gene

Gene Families for CNOT10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNOT10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9A5

UniProtKB/Swiss-Prot:

CNO10_HUMAN :
  • Belongs to the CNOT10 family.
Family:
  • Belongs to the CNOT10 family.
genes like me logo Genes that share domains with CNOT10: view

Function for CNOT10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CNOT10 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Phenotypes From GWAS Catalog for CNOT10 Gene

Gene Ontology (GO) - Molecular Function for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21981923
genes like me logo Genes that share ontologies with CNOT10: view
genes like me logo Genes that share phenotypes with CNOT10: view

Animal Model Products

miRNA for CNOT10 Gene

miRTarBase miRNAs that target CNOT10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT10 Gene

Localization for CNOT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT10 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,HDA 19946888
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT10: view

Pathways & Interactions for CNOT10 Gene

genes like me logo Genes that share pathways with CNOT10: view

Gene Ontology (GO) - Biological Process for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CNOT10: view

No data available for SIGNOR curated interactions for CNOT10 Gene

Drugs & Compounds for CNOT10 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CNOT10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CNOT10 Gene

(11) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(158) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNOT10 Gene

CCR4-NOT transcription complex, subunit 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8:
SP9:
SP10: - -
SP11: -
SP12:

Relevant External Links for CNOT10 Gene

GeneLoc Exon Structure for
CNOT10
ECgene alternative splicing isoforms for
CNOT10

Expression for CNOT10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNOT10 Gene

mRNA expression in normal human tissues for CNOT10 Gene
mRNA expression by GTEx for CNOT10 GenemRNA expression by BioGPS for CNOT10 Gene

Protein differential expression in normal tissues from HIPED for CNOT10 Gene

This gene is overexpressed in Monocytes (9.3) and Breast (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT10 Gene



Protein tissue co-expression partners for CNOT10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT10 Gene:

CNOT10

SOURCE GeneReport for Unigene cluster for CNOT10 Gene:

Hs.444851

Evidence on tissue expression from TISSUES for CNOT10 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with CNOT10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT10 Gene

Orthologs for CNOT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CNOT10 33 34
  • 99.92 (n)
dog
(Canis familiaris)
 Mammalia CNOT10 33 34
  • 93.19 (n)
cow
(Bos Taurus)
 Mammalia CNOT10 33 34
  • 92.58 (n)
mouse
(Mus musculus)
 Mammalia Cnot10 33 16 34
  • 88.39 (n)
rat
(Rattus norvegicus)
 Mammalia Cnot10 33
  • 88.35 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CNOT10 34
  • 84 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CNOT10 34
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CNOT10 33 34
  • 82.32 (n)
lizard
(Anolis carolinensis)
 Reptilia CNOT10 34
  • 90 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cnot10 33
  • 76.96 (n)
Str.11981 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.8121 33
zebrafish
(Danio rerio)
 Actinopterygii cnot10 33 34
  • 71.19 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009674 33
  • 43.25 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG18616 33 34
  • 40.29 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G35430 33
  • 44.41 (n)
rice
(Oryza sativa)
 Liliopsida Os09g0123100 33
  • 43.73 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2239 34
  • 32 (a)
 OneToOne
Species where no ortholog for CNOT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNOT10 Gene

ENSEMBL:
Gene Tree for CNOT10 (if available)
TreeFam:
Gene Tree for CNOT10 (if available)

Paralogs for CNOT10 Gene

No data available for Paralogs for CNOT10 Gene

Variants for CNOT10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CNOT10 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000033811 -- 32,771,664(+) A/C intron_variant
rs1000045875 -- 32,730,036(+) G/T intron_variant
rs1000079858 -- 32,692,074(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000112149 -- 32,764,042(+) A/G intron_variant
rs1000154190 -- 32,724,615(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT10 Gene

Variant ID Type Subtype PubMed ID
esv1454338 CNV deletion 17803354
esv2515147 CNV deletion 19546169
esv2657972 CNV deletion 23128226
esv2725112 CNV deletion 23290073
esv2837125 CNV deletion 24192839
esv3561707 CNV deletion 23714750
esv3595781 CNV loss 21293372
esv999127 CNV deletion 20482838
nsv1003285 CNV gain 25217958
nsv1004530 CNV gain 25217958
nsv1072302 CNV deletion 25765185
nsv1072679 CNV deletion 25765185
nsv1121728 CNV deletion 24896259
nsv1122061 CNV deletion 24896259
nsv1149497 CNV deletion 26484159
nsv237812 CNV deletion 16902084
nsv508908 CNV insertion 20534489
nsv513041 CNV loss 21212237
nsv822050 CNV loss 20364138
nsv998302 CNV gain 25217958

Variation tolerance for CNOT10 Gene

Residual Variation Intolerance Score: 5.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNOT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT10 Gene

Disorders for CNOT10 Gene

Additional Disease Information for CNOT10

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CNOT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT10 Gene

Publications for CNOT10 Gene

  1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F … Séraphin B (RNA biology 2013) 3 4 58
  2. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P … Izaurralde E (RNA biology 2013) 3 4 58
  3. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau NC … Timmers HT (The Biochemical journal 2009) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CNOT10 Gene

Sources for CNOT10 Gene

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