Aliases for CNNM3 Gene

Aliases for CNNM3 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3 2 3 5
  • Ancient Conserved Domain-Containing Protein 3 3 4
  • Metal Transporter CNNM3 3 4
  • Cyclin-M3 3 4
  • ACDP3 3 4
  • Ancient Conserved Domain Protein 3 3
  • Cyclin M3 2
  • CNNM3 5

External Ids for CNNM3 Gene

Previous HGNC Symbols for CNNM3 Gene

  • ACDP3

Previous GeneCards Identifiers for CNNM3 Gene

  • GC02P095354
  • GC02P095936
  • GC02P096949
  • GC02P096966
  • GC02P096903
  • GC02P096845
  • GC02P097481
  • GC02P091442

Summaries for CNNM3 Gene

GeneCards Summary for CNNM3 Gene

CNNM3 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3) is a Protein Coding gene. Diseases associated with CNNM3 include Pneumonic Tularemia and Jalili Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and adenyl nucleotide binding. An important paralog of this gene is CNNM1.

UniProtKB/Swiss-Prot Summary for CNNM3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNNM3 Gene

Genomics for CNNM3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CNNM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNNM3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNNM3

Top Transcription factor binding sites by QIAGEN in the CNNM3 gene promoter:
  • CP2
  • HOXA5
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • Pbx1a
  • SRF
  • SRF (504 AA)

Genomic Locations for CNNM3 Gene

Genomic Locations for CNNM3 Gene
chr2:96,814,946-96,837,109
(GRCh38/hg38)
Size:
22,164 bases
Orientation:
Plus strand
chr2:97,481,982-97,501,121
(GRCh37/hg19)
Size:
19,140 bases
Orientation:
Plus strand

Genomic View for CNNM3 Gene

Genes around CNNM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNNM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM3 Gene

Proteins for CNNM3 Gene

  • Protein details for CNNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE01-CNNM3_HUMAN
    Recommended name:
    Metal transporter CNNM3
    Protein Accession:
    Q8NE01
    Secondary Accessions:
    • B3KX67
    • Q8TBV4
    • Q96IW4
    • Q9NRK4
    • Q9NXW6

    Protein attributes for CNNM3 Gene

    Size:
    707 amino acids
    Molecular mass:
    76119 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07199.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90891.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.

    Three dimensional structures from OCA and Proteopedia for CNNM3 Gene

    Alternative splice isoforms for CNNM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNNM3 Gene

Post-translational modifications for CNNM3 Gene

  • Glycosylation at Asn73
  • Ubiquitination at Lys306, Lys462, Lys519, Lys526, and Lys640
  • Modification sites at PhosphoSitePlus

Other Protein References for CNNM3 Gene

No data available for DME Specific Peptides for CNNM3 Gene

Domains & Families for CNNM3 Gene

Gene Families for CNNM3 Gene

Protein Domains for CNNM3 Gene

InterPro:
Blocks:
  • CBS domain
  • CBS
ProtoNet:

Suggested Antigen Peptide Sequences for CNNM3 Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-M3 (CNNM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NE01

UniProtKB/Swiss-Prot:

CNNM3_HUMAN :
  • Belongs to the ACDP family.
Family:
  • Belongs to the ACDP family.
genes like me logo Genes that share domains with CNNM3: view

Function for CNNM3 Gene

Molecular function for CNNM3 Gene

UniProtKB/Swiss-Prot Function:
Probable metal transporter.

Phenotypes From GWAS Catalog for CNNM3 Gene

Gene Ontology (GO) - Molecular Function for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0022857 transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with CNNM3: view
genes like me logo Genes that share phenotypes with CNNM3: view

Animal Model Products

CRISPR Products

miRNA for CNNM3 Gene

miRTarBase miRNAs that target CNNM3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNNM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNNM3 Gene

Localization for CNNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNNM3 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNNM3: view

Pathways & Interactions for CNNM3 Gene

PathCards logo

SuperPathways for CNNM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA 21873635
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with CNNM3: view

No data available for Pathways by source and SIGNOR curated interactions for CNNM3 Gene

Drugs & Compounds for CNNM3 Gene

No Compound Related Data Available

Transcripts for CNNM3 Gene

mRNA/cDNA for CNNM3 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNNM3

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for CNNM3 Gene

GeneLoc Exon Structure for
CNNM3

Expression for CNNM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNNM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNNM3 Gene

This gene is overexpressed in Fetal Brain (19.3), Pancreas (11.3), Placenta (8.5), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNNM3 Gene



Protein tissue co-expression partners for CNNM3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNNM3

SOURCE GeneReport for Unigene cluster for CNNM3 Gene:

Hs.711617

mRNA Expression by UniProt/SwissProt for CNNM3 Gene:

Q8NE01-CNNM3_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen.

Evidence on tissue expression from TISSUES for CNNM3 Gene

  • Nervous system(4.5)
  • Muscle(4.4)
  • Adrenal gland(4.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CNNM3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNNM3 Gene

Orthologs for CNNM3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CNNM3 30 31
  • 99.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CNNM3 30 31
  • 90.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CNNM3 30 31
  • 89.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cnnm3 30 17 31
  • 86.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cnnm3 30
  • 86.84 (n)
Oppossum
(Monodelphis domestica)
Mammalia CNNM3 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CNNM3 31
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CNNM3 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cnnm3 30
  • 62.59 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100329721 30
  • 62.84 (n)
CABZ01071058.1 31
  • 49 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta uex 31
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C33D12.2 31
  • 23 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 31
  • 18 (a)
OneToMany
Species where no ortholog for CNNM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CNNM3 Gene

ENSEMBL:
Gene Tree for CNNM3 (if available)
TreeFam:
Gene Tree for CNNM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNNM3: view image

Paralogs for CNNM3 Gene

Paralogs for CNNM3 Gene

(3) SIMAP similar genes for CNNM3 Gene using alignment to 1 proteins:

  • CNNM3_HUMAN
genes like me logo Genes that share paralogs with CNNM3: view

Variants for CNNM3 Gene

Additional dbSNP identifiers (rs#s) for CNNM3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CNNM3 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1072008 CNV deletion 25765185
nsv1112766 CNV deletion 24896259
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680

Variation tolerance for CNNM3 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNNM3 Gene

Human Gene Mutation Database (HGMD)
CNNM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNNM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNNM3 Gene

Disorders for CNNM3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CNNM3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pneumonic tularemia
  • bronchopneumonic tularemia
jalili syndrome
  • cone-rod dystrophy and amelogenesis imperfecta
urofacial syndrome 1
  • ufs1
- elite association - COSMIC cancer census association via MalaCards
Search CNNM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CNNM3

genes like me logo Genes that share disorders with CNNM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNNM3 Gene

Publications for CNNM3 Gene

  1. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. (PMID: 24632616) Hardy S … Tremblay ML (Oncogene 2015) 2 3
  2. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) Gómez García I … Martínez-Cruz LA (Acta crystallographica. Section F, Structural biology and crystallization communications 2011) 2 3
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PMID: 12657465) Wang CY … She JX (Gene 2003) 3 4

Products for CNNM3 Gene

  • Signalway Proteins for CNNM3

Sources for CNNM3 Gene