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Aliases for CNNM3 Gene

Aliases for CNNM3 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3 2 3 5
  • Ancient Conserved Domain-Containing Protein 3 3 4
  • Cyclin-M3 3 4
  • ACDP3 3 4
  • Ancient Conserved Domain Protein 3 3
  • Metal Transporter CNNM3 3
  • Cyclin M3 2

External Ids for CNNM3 Gene

Previous HGNC Symbols for CNNM3 Gene

  • ACDP3

Previous GeneCards Identifiers for CNNM3 Gene

  • GC02P095354
  • GC02P095936
  • GC02P096949
  • GC02P096966
  • GC02P096903
  • GC02P096845
  • GC02P097481
  • GC02P091442

Summaries for CNNM3 Gene

GeneCards Summary for CNNM3 Gene

CNNM3 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and adenyl nucleotide binding. An important paralog of this gene is CNNM1.

UniProtKB/Swiss-Prot for CNNM3 Gene

  • Probable metal transporter.

Additional gene information for CNNM3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNNM3 Gene

Genomics for CNNM3 Gene

GeneHancer (GH) Regulatory Elements for CNNM3 Gene

Promoters and enhancers for CNNM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I096815 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.5 1537 2.7 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS CNNM3 KANSL3 SNRNP200 STARD7-AS1 ANKRD36 SEMA4C CNNM4 GC02P096839
GH02I096206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -606.2 -606214 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B STARD7-AS1 STARD7 KANSL3 SNRNP200 ANKRD36 LMAN2L CNNM3 SEMA4C GPAT2 CIAO1
GH02I096263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 -549.1 -549092 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 CIAO1 TMEM127 SNRNP200 KANSL3 ITPRIPL1 ENSG00000230747 CNNM3 ANKRD36 NCAPH ASTL
GH02I096636 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -177.2 -177244 2.8 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC KANSL3 SNRNP200 CNNM3 ANKRD36B STARD7-AS1 LMAN2L CIAO1 FER1L5 GC02P096595
GH02I097712 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +901.3 901273 7.6 PKNOX1 ATF1 TCF12 ZNF766 CAVIN1 ZNF592 KAT8 MEF2D MIER3 SMARCA4 ZAP70 ANKRD36B LMAN2L UNC50 ACTR1B ANKRD36 CNNM3 SEMA4C TMEM131 FAHD2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNNM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNNM3 gene promoter:

Genomic Locations for CNNM3 Gene

Genomic Locations for CNNM3 Gene
chr2:96,814,952-96,837,466
(GRCh38/hg38)
Size:
22,515 bases
Orientation:
Plus strand
chr2:97,481,982-97,501,121
(GRCh37/hg19)

Genomic View for CNNM3 Gene

Genes around CNNM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNNM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM3 Gene

Proteins for CNNM3 Gene

  • Protein details for CNNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE01-CNNM3_HUMAN
    Recommended name:
    Metal transporter CNNM3
    Protein Accession:
    Q8NE01
    Secondary Accessions:
    • B3KX67
    • Q8TBV4
    • Q96IW4
    • Q9NRK4
    • Q9NXW6

    Protein attributes for CNNM3 Gene

    Size:
    707 amino acids
    Molecular mass:
    76119 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.
    SequenceCaution:
    • Sequence=AAF86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07199.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90891.1; Type=Frameshift; Positions=315; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNNM3 Gene

    Alternative splice isoforms for CNNM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNNM3 Gene

Post-translational modifications for CNNM3 Gene

  • Ubiquitination at Lys462, Lys519, Lys526, and Lys640
  • Glycosylation at posLast=7373
  • Modification sites at PhosphoSitePlus

Other Protein References for CNNM3 Gene

No data available for DME Specific Peptides for CNNM3 Gene

Domains & Families for CNNM3 Gene

Gene Families for CNNM3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CNNM3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNNM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NE01

UniProtKB/Swiss-Prot:

CNNM3_HUMAN :
  • Belongs to the ACDP family.
Family:
  • Belongs to the ACDP family.
genes like me logo Genes that share domains with CNNM3: view

Function for CNNM3 Gene

Molecular function for CNNM3 Gene

UniProtKB/Swiss-Prot Function:
Probable metal transporter.

Phenotypes From GWAS Catalog for CNNM3 Gene

Gene Ontology (GO) - Molecular Function for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CNNM3: view

Phenotypes for CNNM3 Gene

genes like me logo Genes that share phenotypes with CNNM3: view

Animal Model Products

CRISPR Products

miRNA for CNNM3 Gene

miRTarBase miRNAs that target CNNM3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNNM3 Gene

Localization for CNNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNNM3 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNNM3: view

Pathways & Interactions for CNNM3 Gene

SuperPathways for CNNM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with CNNM3: view

No data available for Pathways by source and SIGNOR curated interactions for CNNM3 Gene

Drugs & Compounds for CNNM3 Gene

No Compound Related Data Available

Transcripts for CNNM3 Gene

Unigene Clusters for CNNM3 Gene

Cyclin M3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for CNNM3 Gene

GeneLoc Exon Structure for
CNNM3
ECgene alternative splicing isoforms for
CNNM3

Expression for CNNM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNNM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNNM3 Gene

This gene is overexpressed in Fetal Brain (19.3), Pancreas (11.3), Placenta (8.5), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNNM3 Gene



Protein tissue co-expression partners for CNNM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNNM3 Gene:

CNNM3

SOURCE GeneReport for Unigene cluster for CNNM3 Gene:

Hs.711617

mRNA Expression by UniProt/SwissProt for CNNM3 Gene:

Q8NE01-CNNM3_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen.

Evidence on tissue expression from TISSUES for CNNM3 Gene

  • Nervous system(4.3)
  • Adrenal gland(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with CNNM3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNNM3 Gene

Orthologs for CNNM3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNNM3 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia CNNM3 33 34
  • 90.23 (n)
cow
(Bos Taurus)
Mammalia CNNM3 33 34
  • 89.39 (n)
mouse
(Mus musculus)
Mammalia Cnnm3 33 16 34
  • 86.98 (n)
rat
(Rattus norvegicus)
Mammalia Cnnm3 33
  • 86.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CNNM3 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNNM3 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNNM3 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnnm3 33
  • 62.59 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329721 33
  • 62.84 (n)
CABZ01071058.1 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta uex 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33D12.2 34
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 34
  • 18 (a)
OneToMany
Species where no ortholog for CNNM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNNM3 Gene

ENSEMBL:
Gene Tree for CNNM3 (if available)
TreeFam:
Gene Tree for CNNM3 (if available)

Paralogs for CNNM3 Gene

Paralogs for CNNM3 Gene

(3) SIMAP similar genes for CNNM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNNM3: view

Variants for CNNM3 Gene

Sequence variations from dbSNP and Humsavar for CNNM3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000127740 -- 96,815,099(+) T/C upstream_transcript_variant
rs1000182020 -- 96,815,421(+) A/G upstream_transcript_variant
rs1000354178 -- 96,821,384(+) A/G intron_variant
rs1000403109 -- 96,827,091(+) C/T intron_variant
rs1000640626 -- 96,822,717(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNNM3 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1072008 CNV deletion 25765185
nsv1112766 CNV deletion 24896259
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680

Variation tolerance for CNNM3 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNNM3 Gene

Human Gene Mutation Database (HGMD)
CNNM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNNM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNNM3 Gene

Disorders for CNNM3 Gene

Additional Disease Information for CNNM3

No disorders were found for CNNM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNNM3 Gene

Publications for CNNM3 Gene

  1. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. (PMID: 24632616) Hardy S … Tremblay ML (Oncogene 2015) 2 3 58
  2. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) Gómez García I … Martínez-Cruz LA (Acta crystallographica. Section F, Structural biology and crystallization communications 2011) 2 3 58
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PMID: 12657465) Wang CY … She JX (Gene 2003) 3 4 58

Products for CNNM3 Gene

Sources for CNNM3 Gene

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