Aliases for CNNM2 Gene
External Ids for CNNM2 Gene
Previous HGNC Symbols for CNNM2 Gene
Previous GeneCards Identifiers for CNNM2 Gene
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for CNNM2 Gene
CNNM2 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 2) is a Protein Coding gene. Diseases associated with CNNM2 include Hypomagnesemia, Seizures, And Mental Retardation 1 and Hypomagnesemia 6, Renal. Gene Ontology (GO) annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM4.
UniProtKB/Swiss-Prot Summary for CNNM2 Gene
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).