This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008] See more...

Aliases for CNN3 Gene

Aliases for CNN3 Gene

  • Calponin 3 2 3 5
  • Calponin 3, Acidic 2 3
  • Calponin-3 3 4
  • DJ639P13.2.2 (Acidic Calponin 3) 3
  • Calponin, Acidic Isoform 4
  • CNN3 5

External Ids for CNN3 Gene

Previous GeneCards Identifiers for CNN3 Gene

  • GC01M095763
  • GC01M094568
  • GC01M094713
  • GC01M094834
  • GC01M095074
  • GC01M095135
  • GC01M095362
  • GC01M093484

Summaries for CNN3 Gene

Entrez Gene Summary for CNN3 Gene

  • This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNN3 Gene

CNN3 (Calponin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN1.

UniProtKB/Swiss-Prot Summary for CNN3 Gene

  • Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNN3 Gene

Genomics for CNN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CNN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNN3

Top Transcription factor binding sites by QIAGEN in the CNN3 gene promoter:
  • AML1a
  • AP-4
  • c-Myb
  • C/EBPalpha
  • ER-alpha
  • Nkx2-5
  • p53
  • Pax-5
  • XBP-1

Genomic Locations for CNN3 Gene

Latest Assembly
chr1:94,896,949-94,927,223
(GRCh38/hg38)
Size:
30,275 bases
Orientation:
Minus strand

Previous Assembly
chr1:95,362,513-95,392,666
(GRCh37/hg19 by Entrez Gene)
Size:
30,154 bases
Orientation:
Minus strand

chr1:95,362,507-95,392,834
(GRCh37/hg19 by Ensembl)
Size:
30,328 bases
Orientation:
Minus strand

Genomic View for CNN3 Gene

Genes around CNN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNN3 Gene

Proteins for CNN3 Gene

  • Protein details for CNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15417-CNN3_HUMAN
    Recommended name:
    Calponin-3
    Protein Accession:
    Q15417
    Secondary Accessions:
    • B4DFK6
    • B4DP09
    • F8WA86
    • Q6FHA7

    Protein attributes for CNN3 Gene

    Size:
    329 amino acids
    Molecular mass:
    36414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNN3 Gene

Post-translational modifications for CNN3 Gene

  • Ubiquitination at Lys256
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for CNN3 Gene

No data available for DME Specific Peptides for CNN3 Gene

Domains & Families for CNN3 Gene

Gene Families for CNN3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CNN3 Gene

InterPro:
Blocks:
  • Calponin-like actin-binding
  • Calponin signature
  • Calponin-like actin-binding subtype

Suggested Antigen Peptide Sequences for CNN3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79297, highly similar to Calponin-3 (B4DFK6_HUMAN)
  • Calponin, acidic isoform (CNN3_HUMAN)
  • cDNA, FLJ92692, Homo sapiens calponin 3, acidic (CNN3), mRNA (Q6FHA7_HUMAN)
  • DJ639P13.2.2 (Acidic calponin 3) (Q9BWY6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15417

UniProtKB/Swiss-Prot:

CNN3_HUMAN :
  • Belongs to the calponin family.
Family:
  • Belongs to the calponin family.
genes like me logo Genes that share domains with CNN3: view

Function for CNN3 Gene

Molecular function for CNN3 Gene

UniProtKB/Swiss-Prot Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
GENATLAS Biochemistry:
calponin,acidic,36kDa,cytoskeletal protein,ubiquitously expressed in smooth muscle and non smooth muscle tissues,actin,calmodulin,tropomyosin binding,downregulated during dedifferentiation of vascular smooth muscle cell

Phenotypes From GWAS Catalog for CNN3 Gene

Gene Ontology (GO) - Molecular Function for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion HDA 25468996
genes like me logo Genes that share ontologies with CNN3: view

Phenotypes for CNN3 Gene

genes like me logo Genes that share phenotypes with CNN3: view

Animal Models for CNN3 Gene

MGI Knock Outs for CNN3:
  • Cnn3 Cnn3<tm1.2Hjum>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNN3 Gene

Localization for CNN3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 2
nucleus 2
plasma membrane 1
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (4)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005912 adherens junction HDA 25468996
GO:0005925 focal adhesion HDA 21423176
GO:0014069 postsynaptic density IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CNN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNN3 Gene

Pathways & Interactions for CNN3 Gene

PathCards logo

SuperPathways for CNN3 Gene

No Data Available

SIGNOR curated interactions for CNN3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0031032 actomyosin structure organization IEA --
GO:0032780 negative regulation of ATPase activity IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with CNN3: view

No data available for Pathways by source for CNN3 Gene

Drugs & Compounds for CNN3 Gene

No Compound Related Data Available

Transcripts for CNN3 Gene

mRNA/cDNA for CNN3 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNN3

Alternative Splicing Database (ASD) splice patterns (SP) for CNN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7: - - - - -

Relevant External Links for CNN3 Gene

GeneLoc Exon Structure for
CNN3

Expression for CNN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNN3 Gene

Protein differential expression in normal tissues from HIPED for CNN3 Gene

This gene is overexpressed in Bone marrow stromal cell (13.8) and Uterus (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNN3 Gene



Protein tissue co-expression partners for CNN3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNN3

SOURCE GeneReport for Unigene cluster for CNN3 Gene:

Hs.483454

mRNA Expression by UniProt/SwissProt for CNN3 Gene:

Q15417-CNN3_HUMAN
Tissue specificity: Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.

Evidence on tissue expression from TISSUES for CNN3 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Liver(4.5)
  • Skin(3.2)
  • Lung(3.1)
  • Muscle(2.7)
  • Heart(2.6)
  • Intestine(2.4)
  • Thyroid gland(2.3)
  • Spleen(2.2)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Gall bladder(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CNN3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNN3 Gene

Orthologs for CNN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CNN3 29 30
  • 99.8 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CNN3 30
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CNN3 30
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CNN3 29 30
  • 94.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CNN3 29 30
  • 91.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cnn3 29 16 30
  • 90.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cnn3 29
  • 90.07 (n)
Chicken
(Gallus gallus)
Aves CNN3 29 30
  • 83.6 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CNN3 30
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cnn3 29
  • 79.13 (n)
MGC76140 29
African clawed frog
(Xenopus laevis)
Amphibia cnn3-prov 29
Zebrafish
(Danio rerio)
Actinopterygii cnn3b 30
  • 81 (a)
ManyToMany
cnn3a 29
  • 74.92 (n)
wufe49h10 29
Fruit Fly
(Drosophila melanogaster)
Insecta Chd64 29
  • 49.07 (n)
Mp20 30
  • 37 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001313 29
  • 47.51 (n)
Worm
(Caenorhabditis elegans)
Secernentea cpn-2 30
  • 37 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 30
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7148 30
  • 44 (a)
OneToMany
Species where no ortholog for CNN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CNN3 Gene

ENSEMBL:
Gene Tree for CNN3 (if available)
TreeFam:
Gene Tree for CNN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNN3: view image
Alliance of Genome Resources:
Additional Orthologs for CNN3

Paralogs for CNN3 Gene

Paralogs for CNN3 Gene

(14) SIMAP similar genes for CNN3 Gene using alignment to 5 proteins:

  • CNN3_HUMAN
  • B4DFK6_HUMAN
  • E9PDU6_HUMAN
  • F8WA86_HUMAN
  • Q9BWY6_HUMAN

Pseudogenes.org Pseudogenes for CNN3 Gene

genes like me logo Genes that share paralogs with CNN3: view

Variants for CNN3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CNN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CNN3 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNN3
Leiden Open Variation Database (LOVD)
CNN3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CNN3 Gene

Disorders for CNN3 Gene

Additional Disease Information for CNN3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CNN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNN3 Gene

Publications for CNN3 Gene

  1. Molecular cloning and gene mapping of human basic and acidic calponins. (PMID: 8526917) Maguchi M … Hiwada K (Biochemical and biophysical research communications 1995) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PMID: 17620012) Holaska JM … Wilson KL (Biochemistry 2007) 3 22
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CNN3 Gene

Sources for CNN3 Gene