Aliases for CNN2 Gene
Aliases for CNN2 Gene
External Ids for CNN2 Gene
- HGNC: 2156
- Entrez Gene: 1265
- Ensembl: ENSG00000064666
- OMIM: 602373
- UniProtKB: Q99439
Previous GeneCards Identifiers for CNN2 Gene
- GC19P001102
- GC19P000966
- GC19P000977
- GC19P000799
Summaries for CNN2 Gene
-
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
GeneCards Summary for CNN2 Gene
CNN2 (Calponin 2) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN3.
UniProtKB/Swiss-Prot for CNN2 Gene
-
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Additional gene information for CNN2 Gene
- Monarch Initiative
- Search for CNN2 at DataMed
- Search for CNN2 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNN2 Gene
Genomics for CNN2 Gene
GeneHancer (GH) Regulatory Elements for CNN2 Gene
Promoters and enhancers for CNN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CNN2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CNN2 gene promoter:
-
- AP-2gamma
- AP-2beta
- AP-2alphaA
- AP-2alpha
- COMP1
- Brachyury
- NRSF form 1
- NRSF form 2
- Max1
- c-Myc
Regulatory Element Products
Genomic Locations for CNN2 Gene
Genomic Locations for CNN2 Gene
- chr19:1,026,275-1,039,068
- (GRCh38/hg38)
- Size:
- 12,794 bases
- Orientation:
- Plus strand
- chr19:1,026,298-1,039,068
- (GRCh37/hg19)
- Size:
- 12,771 bases
- Orientation:
- Plus strand
Genomic View for CNN2 Gene
Genes around CNN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
- 19p13.3 by Ensembl
CNN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CNN2 Gene
Proteins for CNN2 Gene
-
Protein details for CNN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99439-CNN2_HUMAN
- Recommended name:
- Calponin-2
- Protein Accession:
- Q99439
- A5D8U8
- A6NFI4
- D6W5X9
- Q92578
Protein attributes for CNN2 Gene
- Size:
- 309 amino acids
- Molecular mass:
- 33697 Da
- Quaternary structure:
- No Data Available
Protein Expression for CNN2 Gene
Post-translational modifications for CNN2 Gene
Other Protein References for CNN2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CNN2
- Novus Biologicals Antibodies for CNN2
- Invitrogen Antibodies for CNN2 (AFLGC-CNN2)
- GeneTex CNN2 Antibody for CNN2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CNN2
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- ProSpec Recombinant Proteins for CNN2
- Search GeneTex for Proteins for CNN2
-
Abcam proteins for CNN2
Assay Products
- antibodies-online: Search results for 14 available CNN2 Elisa Kits ranked by validation data
- Compare Top CNN2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CNN2 Gene
Domains & Families for CNN2 Gene
Gene Families for CNN2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CNN2 Gene
Suggested Antigen Peptide Sequences for CNN2 Gene
Graphical View of Domain Structure for InterPro Entry
Q99439- Family:
-
- Belongs to the calponin family.
Function for CNN2 Gene
Molecular function for CNN2 Gene
- UniProtKB/Swiss-Prot Function:
- Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
- GENATLAS Biochemistry:
- calponin neutral,h2,cytoskeletal protein of smooth muscle cells,actin,calmodulin,tropomyosin binding,closely related to non-muscle calponin CNN3
Phenotypes From GWAS Catalog for CNN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for CNN2 Gene
- MGI mutant phenotypes for CNN2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CNN2:
Animal Models for CNN2 Gene
- MGI Knock Outs for CNN2:
-
- Cnn2 Cnn2<tm1.2Jin>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CNN2
-
CRISPR Products
-
OriGene CRISPR knockouts for CNN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CNN2
- genomics-online: gRNA clones - Search results for available CNN2 gene related products
- Applied Biological Materials CRISPR for CNN2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CNN2
- GenScript: Design CRISPR guide RNA sequences for CNN2
miRNA for CNN2 Gene
- miRTarBase miRNAs that target CNN2
-
- hsa-mir-133a-3p (MIRT021704)
- hsa-mir-744-5p (MIRT037661)
- hsa-mir-346 (MIRT042725)
- hsa-mir-219b-3p (MIRT479104)
- hsa-mir-489-5p (MIRT479105)
- hsa-mir-6854-3p (MIRT479106)
- hsa-mir-140-3p (MIRT479107)
- hsa-mir-4257 (MIRT479108)
- hsa-mir-205-3p (MIRT479109)
- hsa-mir-329-5p (MIRT479110)
- hsa-mir-137 (MIRT479111)
- hsa-mir-133b (MIRT479112)
- hsa-mir-23a-3p (MIRT479113)
- hsa-mir-23b-3p (MIRT479114)
- hsa-mir-23c (MIRT479115)
- hsa-mir-130a-5p (MIRT479116)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNN2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNN2
- genomics-online: shRNA clones - Search results for available CNN2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CNN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CNN2
- genomics-online: cdna clones - Search results for available CNN2 gene related products
- orf clones - Search results for available CNN2 gene related products
- Applied Biological Materials Clones for CNN2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CNN2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNN2 Gene
Localization for CNN2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 4 |
| nucleus | 3 |
| mitochondrion | 1 |
- Actin filaments (2)
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IDA | 16236705 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005856 | cytoskeleton | IEA,TAS | 8889829 |
| GO:0005911 | cell-cell junction | TAS | 8889829 |
| GO:0005925 | focal adhesion | HDA | 21423176 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNN2 Gene
Pathways & Interactions for CNN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Myometrial Relaxation and Contraction Pathways | ||
Pathways by source for CNN2 Gene
1 BioSystems pathway for CNN2 Gene
3 Reactome pathways for CNN2 Gene
Interacting Proteins for CNN2 Gene
GPS-Prot Interaction Network for CNN2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA,TAS | 8889829 |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0030097 | hemopoiesis | IEA | -- |
| GO:0030336 | negative regulation of cell migration | IEA | -- |
| GO:0031032 | actomyosin structure organization | IEA | -- |
No data available for SIGNOR curated interactions for CNN2 Gene
Transcripts for CNN2 Gene
mRNA/cDNA for CNN2 Gene
- (4) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000263097 2179 bps (uc002lqu.4)
- ENST00000562015 563 bps (uc060qtp.1)
- ENST00000348419 2033 bps (uc002lqv.4)
- ENST00000565096 2109 bps (uc010xgb.3)
- ENST00000569352 731 bps (uc060qtq.1)
CRISPR Products
-
OriGene CRISPR knockouts for CNN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CNN2
- genomics-online: gRNA clones - Search results for available CNN2 gene related products
- Applied Biological Materials CRISPR for CNN2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CNN2
- GenScript: Design CRISPR guide RNA sequences for CNN2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNN2
- Browse OriGene Inhibitory RNA Products For CNN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNN2
- genomics-online: shRNA clones - Search results for available CNN2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CNN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CNN2
- genomics-online: cdna clones - Search results for available CNN2 gene related products
- orf clones - Search results for available CNN2 gene related products
- Applied Biological Materials Clones for CNN2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | - |
Expression for CNN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Heart (Cardiovascular System)
- Bone (Muscoskeletal System)
- Smooth Muscle (Muscoskeletal System)
- Epiblast (Early Embryonic Tissues)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for CNN2 Gene
This gene is overexpressed in Whole Blood (x12.5).
This gene is overexpressed in Bone marrow stromal cell (8.8), Platelet (8.3), and Lymph node (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNN2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CNN2 Gene:
CNN2SOURCE GeneReport for Unigene cluster for CNN2 Gene:
Hs.651512mRNA Expression by UniProt/SwissProt for CNN2 Gene:
Q99439-CNN2_HUMAN
Tissue specificity:
Heart and smooth muscle.
Evidence on tissue expression from TISSUES for CNN2 Gene
- Blood(4.8)
- Nervous system(4.4)
- Heart(4.3)
- Skin(3.9)
- Lung(3.1)
- Kidney(3)
- Intestine(2.5)
- Spleen(2.5)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for CNN2
-
OriGene qPCR primer pairs and template standards for CNN2
- genomics-online: primer clones - Search results for available CNN2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CNN2 Gene
Orthologs for CNN2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | CNN2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CNN2 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cnn2 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CNN2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cnn2 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CNN2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CNN2 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cnn1 33 |
|
||
| Str.6304 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cnn2-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cnn2 34 33 |
|
OneToOne | |
| Dr.28235 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Mp20 34 33 |
|
ManyToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012304 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cpn-2 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCP1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7148 34 |
|
OneToMany |
- Species where no ortholog for CNN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CNN2 Gene
- ENSEMBL:
- Gene Tree for CNN2 (if available)
- TreeFam:
- Gene Tree for CNN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CNN2: view image
Paralogs for CNN2 Gene
(26) SIMAP similar genes for CNN2 Gene using alignment to 9 proteins:
- CNN2_HUMAN
- B4DDF4_HUMAN
- B4DUT8_HUMAN
- H3BQH0_HUMAN
- H3BVI6_HUMAN
- K7ES69_HUMAN
- Q6FHC3_HUMAN
- Q6FHE4_HUMAN
- U3KPS3_HUMAN
Pseudogenes.org Pseudogenes for CNN2 Gene
- PGOHUM00000290766
- PGOHUM00000292068
- PGOHUM00000292960
- PGOHUM00000293635
- PGOHUM00000296642
- PGOHUM00000297342
- PGOHUM00000297514
- PGOHUM00000298001
- PGOHUM00000298550
- PGOHUM00000298982
- PGOHUM00000301914
- PGOHUM00000303814
- PGOHUM00000303842
- PGOHUM00000303883
- PGOHUM00000303905
- PGOHUM00000304201
- PGOHUM00000304232
- PGOHUM00000304277
- PGOHUM00000304294
Variants for CNN2 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049566 | -- | 1,028,702(+) | G/C/T | intron_variant | |
| rs1000162724 | -- | 1,028,096(+) | G/A | intron_variant | |
| rs1000207698 | -- | 1,037,211(+) | C/T | intron_variant | |
| rs1000277113 | -- | 1,035,236(+) | C/T | intron_variant | |
| rs1000407997 | -- | 1,039,274(+) | C/T | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv135n111 | CNV | deletion | 26073780 |
| dgv136n111 | CNV | deletion | 26073780 |
| dgv486e201 | CNV | deletion | 23290073 |
| dgv487e201 | CNV | deletion | 23290073 |
| esv1006717 | CNV | loss | 20482838 |
| esv1680853 | CNV | deletion | 17803354 |
| esv2044506 | CNV | deletion | 18987734 |
| esv22453 | CNV | loss | 19812545 |
| esv2492823 | CNV | deletion | 19546169 |
| esv25790 | CNV | loss | 19812545 |
| esv2586842 | CNV | deletion | 19546169 |
| esv2677837 | CNV | deletion | 23128226 |
| esv2758743 | CNV | gain+loss | 17122850 |
| esv3102679 | CNV | deletion | 24192839 |
| esv3643383 | CNV | gain | 21293372 |
| nsv1143894 | CNV | deletion | 24896259 |
| nsv1160555 | CNV | deletion | 26073780 |
| nsv469845 | CNV | loss | 16826518 |
| nsv512556 | CNV | loss | 21212237 |
| nsv578188 | CNV | loss | 21841781 |
| nsv833704 | CNV | gain | 17160897 |
| nsv953938 | CNV | deletion | 24416366 |
| nsv960770 | CNV | duplication | 23825009 |
| nsv9662 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.88;
18.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CNN2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNN2 Gene
Disorders for CNN2 Gene
Additional Disease Information for CNN2
No disorders were found for CNN2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNN2 Gene
Publications for CNN2 Gene
- Molecular cloning and characterization of human non-smooth muscle calponin. (PMID: 8889829) Masuda H … Takahashi K (Journal of biochemistry 1996) 2 3 4 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
- A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21. (PMID: 9001224) Kuromitsu J … Hayashizaki Y (Molecular and cellular biology 1997) 3 4 58
- Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations. (PMID: 28378594) Sala S … Ampe C (Journal of proteome research 2017) 3 58
Products for CNN2 Gene
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- antibodies-online: Search results for 96 available CNN2 Antibodies ranked by validation data
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- Quality Products:
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- Quality Products:
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- Horizon Cell Lines for CNN2
- genomics-online: cdna clones - Search results for available CNN2 gene related products
- orf clones - Search results for available CNN2 gene related products
- genomics-online: gRNA clones - Search results for available CNN2 gene related products
- genomics-online: primer clones - Search results for available CNN2 gene related products
- genomics-online: shRNA clones - Search results for available CNN2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CNN2
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Sources for CNN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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