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The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
CNN2 (Calponin 2) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | IEA | -- |
GO:0005515 | protein binding | IEA | -- |
GO:0005516 | calmodulin binding | IEA | -- |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001725 | stress fiber | IDA | 16236705 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005856 | cytoskeleton | IEA,TAS | 8889829 |
GO:0005911 | cell-cell junction | TAS | 8889829 |
GO:0005925 | focal adhesion | HDA | 21423176 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Myometrial Relaxation and Contraction Pathways |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007010 | cytoskeleton organization | IEA,TAS | 8889829 |
GO:0010628 | positive regulation of gene expression | IEA | -- |
GO:0030097 | hemopoiesis | IEA | -- |
GO:0030336 | negative regulation of cell migration | IEA | -- |
GO:0031032 | actomyosin structure organization | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||
SP4: | - | ||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | CNN2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cnn2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CNN2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CNN2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cnn2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CNN2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CNN2 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cnn1 30 |
|
||
Str.6304 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | cnn2-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cnn2 30 31 |
|
OneToOne | |
Dr.28235 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mp20 30 31 |
|
ManyToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012304 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cpn-2 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCP1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7148 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv135n111 | CNV | deletion | 26073780 |
dgv136n111 | CNV | deletion | 26073780 |
dgv486e201 | CNV | deletion | 23290073 |
dgv487e201 | CNV | deletion | 23290073 |
esv1006717 | CNV | loss | 20482838 |
esv1680853 | CNV | deletion | 17803354 |
esv2044506 | CNV | deletion | 18987734 |
esv22453 | CNV | loss | 19812545 |
esv2492823 | CNV | deletion | 19546169 |
esv25790 | CNV | loss | 19812545 |
esv2586842 | CNV | deletion | 19546169 |
esv2677837 | CNV | deletion | 23128226 |
esv2758743 | CNV | gain+loss | 17122850 |
esv3102679 | CNV | deletion | 24192839 |
esv3643383 | CNV | gain | 21293372 |
nsv1143894 | CNV | deletion | 24896259 |
nsv1160555 | CNV | deletion | 26073780 |
nsv469845 | CNV | loss | 16826518 |
nsv512556 | CNV | loss | 21212237 |
nsv578188 | CNV | loss | 21841781 |
nsv833704 | CNV | gain | 17160897 |
nsv953938 | CNV | deletion | 24416366 |
nsv960770 | CNV | duplication | 23825009 |
nsv9662 | CNV | gain | 18304495 |
No disorders were found for CNN2 Gene.