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Aliases for CNIH4 Gene

Aliases for CNIH4 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 4 2 3 4 5
  • CNIH-4 3 4
  • Cornichon Homolog 4 (Drosophila) 2
  • Protein Cornichon Homolog 4 3
  • Cornichon Homolog 4 3
  • HSPC163 3
  • CNIH2 3

External Ids for CNIH4 Gene

Previous GeneCards Identifiers for CNIH4 Gene

  • GC01P220852
  • GC01P222611
  • GC01P224545
  • GC01P195064

Summaries for CNIH4 Gene

GeneCards Summary for CNIH4 Gene

CNIH4 (Cornichon Family AMPA Receptor Auxiliary Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include CCR5 chemokine receptor binding. An important paralog of this gene is CNIH1.

UniProtKB/Swiss-Prot for CNIH4 Gene

  • Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Gene Wiki entry for CNIH4 Gene

Additional gene information for CNIH4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH4 Gene

Genomics for CNIH4 Gene

GeneHancer (GH) Regulatory Elements for CNIH4 Gene

Promoters and enhancers for CNIH4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I224356 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 587.2 +0.6 597 2.4 PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 POLR2B ZNF766 CNIH4 NVL WDR26 CNIH3 LOC101927164 LOC101927143 CAPN2 DEGS1 FBXO28 GC01P224379
GH01I224429 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 36.3 +76.7 76697 7.2 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D ZNF610 CNIH3 WDR26 CNIH4 NVL CICP5 GTF2IP20 GC01P224430
GH01I224456 Enhancer 1.2 Ensembl ENCODE dbSUPER 46.6 +101.4 101414 4.1 HDGF MZF1 ZNF2 RAD21 RFX5 ZNF335 ARID2 EGR1 ZNF143 ATF7 CNIH4 NVL CICP5 CNIH3 WDR26 LOC100287497 DEGS1 GC01M224438 GC01P224480
GH01I224376 Enhancer 1 Ensembl ENCODE 48.1 +22.0 22033 4.9 HDGF PKNOX1 FEZF1 BATF ZNF2 ZNF121 ATF7 FOS IKZF2 RUNX3 GC01P224379 CNIH4 NVL WDR26 CNIH3 MIR4742
GH01I224501 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +146.5 146542 3 FEZF1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 MEF2D NVL CICP5 LOC100287497 WDR26 CNIH4 GTF2IP20 CNIH3 CAPN2 LOC105373110 GC01P224480
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNIH4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNIH4 gene promoter:

Genomic Locations for CNIH4 Gene

Genomic Locations for CNIH4 Gene
22,649 bases
Plus strand

Genomic View for CNIH4 Gene

Genes around CNIH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNIH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNIH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH4 Gene

Proteins for CNIH4 Gene

  • Protein details for CNIH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein cornichon homolog 4
    Protein Accession:
    Secondary Accessions:
    • A8K1Q8
    • B2R553
    • Q9H0X8

    Protein attributes for CNIH4 Gene

    139 amino acids
    Molecular mass:
    16093 Da
    Quaternary structure:
    • Interacts with Sec23/24 complex components SEC24B and SEC24D (PubMed:24405750). Interacts with CCR5 (PubMed:24405750). Interacts with ADRB2 in the early secretory pathway (PubMed:24405750).

    Alternative splice isoforms for CNIH4 Gene


neXtProt entry for CNIH4 Gene

Post-translational modifications for CNIH4 Gene

No Post-translational modifications

Other Protein References for CNIH4 Gene

No data available for DME Specific Peptides for CNIH4 Gene

Domains & Families for CNIH4 Gene

Gene Families for CNIH4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CNIH4 Gene


Suggested Antigen Peptide Sequences for CNIH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornichon family.
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH4: view

Function for CNIH4 Gene

Molecular function for CNIH4 Gene

UniProtKB/Swiss-Prot Function:
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Phenotypes From GWAS Catalog for CNIH4 Gene

Gene Ontology (GO) - Molecular Function for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24405750
GO:0031730 CCR5 chemokine receptor binding IPI 24405750
genes like me logo Genes that share ontologies with CNIH4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNIH4 Gene

Localization for CNIH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH4 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNIH4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 24405750
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA,IDA 24405750
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNIH4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CNIH4 Gene

Pathways & Interactions for CNIH4 Gene

SuperPathways for CNIH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 24405750
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with CNIH4: view

No data available for Pathways by source and SIGNOR curated interactions for CNIH4 Gene

Drugs & Compounds for CNIH4 Gene

No Compound Related Data Available

Transcripts for CNIH4 Gene

Unigene Clusters for CNIH4 Gene

Cornichon homolog 4 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -

Relevant External Links for CNIH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNIH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNIH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNIH4 Gene

This gene is overexpressed in Nasal epithelium (12.6), Monocytes (11.0), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNIH4 Gene

Protein tissue co-expression partners for CNIH4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNIH4 Gene:


SOURCE GeneReport for Unigene cluster for CNIH4 Gene:


Evidence on tissue expression from TISSUES for CNIH4 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with CNIH4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNIH4 Gene

Orthologs for CNIH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNIH4 33 34
  • 99.52 (n)
(Monodelphis domestica)
Mammalia CNIH4 34
  • 96 (a)
(Bos Taurus)
Mammalia CNIH4 33 34
  • 93.76 (n)
(Mus musculus)
Mammalia Cnih4 33 16 34
  • 89.93 (n)
(Canis familiaris)
Mammalia CNIH4 33 34
  • 89.66 (n)
(Rattus norvegicus)
Mammalia Cnih4 33
  • 89.45 (n)
(Ornithorhynchus anatinus)
Mammalia CNIH4 34
  • 81 (a)
(Gallus gallus)
Aves CNIH4 33
  • 82.25 (n)
(Anolis carolinensis)
Reptilia CNIH4 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih4 33
  • 78.9 (n)
MGC76215 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16228 33
(Danio rerio)
Actinopterygii cnih4 33 34
  • 74.19 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1830 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009116 33
  • 58.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta cnir 33 34
  • 52.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05478g 33
  • 54.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 33 34
  • 52.63 (n)
ERV15 34 36
  • 33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06922 33
  • 51.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5341 34
  • 50 (a)
Species where no ortholog for CNIH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNIH4 Gene

Gene Tree for CNIH4 (if available)
Gene Tree for CNIH4 (if available)

Paralogs for CNIH4 Gene

Paralogs for CNIH4 Gene

(3) SIMAP similar genes for CNIH4 Gene using alignment to 3 proteins: Pseudogenes for CNIH4 Gene

genes like me logo Genes that share paralogs with CNIH4: view

Variants for CNIH4 Gene

Sequence variations from dbSNP and Humsavar for CNIH4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000050423 -- 224,376,610(+) A/G 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000061791 -- 224,363,349(+) T/C intron_variant
rs1000092634 -- 224,359,298(+) AAGAA/AA intron_variant
rs1000425144 -- 224,359,657(+) A/G intron_variant
rs1000453330 -- 224,378,246(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNIH4 Gene

Variant ID Type Subtype PubMed ID
nsv8868 CNV loss 18304495
nsv469889 CNV gain 16826518
nsv1127063 CNV deletion 24896259
esv2508330 CNV deletion 19546169

Variation tolerance for CNIH4 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNIH4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNIH4 Gene

Disorders for CNIH4 Gene

Additional Disease Information for CNIH4

No disorders were found for CNIH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNIH4 Gene

Publications for CNIH4 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. (PMID: 24405750) Sauvageau E … Bouvier M (Traffic (Copenhagen, Denmark) 2014) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for CNIH4 Gene

Sources for CNIH4 Gene

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