Aliases for CNGA4 Gene
External Ids for CNGA4 Gene
Previous HGNC Symbols for CNGA4 Gene
Previous GeneCards Identifiers for CNGA4 Gene
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CNGA4 Gene
CNGA4 (Cyclic Nucleotide Gated Channel Subunit Alpha 4) is a Protein Coding gene. Diseases associated with CNGA4 include Retinitis Pigmentosa 45 and Achromatopsia 3. Among its related pathways are Sweet Taste Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include ion channel activity and cAMP binding. An important paralog of this gene is CNGA3.
UniProtKB/Swiss-Prot Summary for CNGA4 Gene
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).