Aliases for CNGA4 Gene
External Ids for CNGA4 Gene
Previous HGNC Symbols for CNGA4 Gene
Previous GeneCards Identifiers for CNGA4 Gene
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CNGA4 Gene
CNGA4 (Cyclic Nucleotide Gated Channel Subunit Alpha 4) is a Protein Coding gene. Diseases associated with CNGA4 include Achromatopsia. Among its related pathways are Sweet Taste Signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include ion channel activity and cAMP binding. An important paralog of this gene is CNGA3.
UniProtKB/Swiss-Prot Summary for CNGA4 Gene
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).