The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010] See more...

Aliases for CNGA2 Gene

Aliases for CNGA2 Gene

  • Cyclic Nucleotide Gated Channel Subunit Alpha 2 2 3 5
  • CNG2 2 3 4
  • Cyclic Nucleotide-Gated Olfactory Channel 3 4
  • Cyclic Nucleotide Gated Channel Alpha 2 2 3
  • CNG Channel Alpha-2 3 4
  • OCNCALPHA 2 3
  • CNCA1 3 4
  • OCNC1 2 3
  • OCNCa 2 3
  • CNCA 3 4
  • Cyclic-Nucleotide-Gated Cation Channel 2 3
  • Cyclic Nucleotide-Gated Cation Channel 2 4
  • Cyclic Nucleotide-Gated Channel Alpha-2 4
  • OCNCalpha 2
  • FLJ46312 2
  • CNGA2 5
  • CNCG2 4
  • CNG-2 4

External Ids for CNGA2 Gene

Previous HGNC Symbols for CNGA2 Gene

  • CNCA1
  • CNCA

Previous GeneCards Identifiers for CNGA2 Gene

  • GC0XU990031
  • GC0XP148659
  • GC0XP149529
  • GC0XP149520
  • GC0XP150573
  • GC0XP150904
  • GC0XP139760

Summaries for CNGA2 Gene

Entrez Gene Summary for CNGA2 Gene

  • The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

GeneCards Summary for CNGA2 Gene

CNGA2 (Cyclic Nucleotide Gated Channel Subunit Alpha 2) is a Protein Coding gene. Diseases associated with CNGA2 include Anosmia, Isolated Congenital and Achromatopsia 2. Among its related pathways are Olfactory transduction and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include calmodulin binding and voltage-gated potassium channel activity. An important paralog of this gene is CNGA3.

UniProtKB/Swiss-Prot Summary for CNGA2 Gene

  • Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Gene Wiki entry for CNGA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CNGA2 Gene

Genomics for CNGA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CNGA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ151718 Enhancer 0.3 FANTOM5 14.8 -16.2 -16234 0 ZNF512 CNGA2 FATE1 HSALNG0140681
GH0XJ151753 Enhancer 0.6 Ensembl 0.4 +19.4 19380 1.7 CEBPA NFIC CEBPB REST CTCF MAX EP300 RAD21 SMC3 ZKSCAN1 piR-61145 CNGA2 MAGEA4
GH0XJ151723 Enhancer 0.5 Ensembl 0.4 -11.6 -11645 0.6 REST CTCF RAD21 ZNF274 NRF1 CREM RB1 HSALNG0140681 lnc-GABRE-3 lnc-GABRE-4 FATE1 CNGA2
GH0XJ151788 Enhancer 0.8 FANTOM5 Ensembl ENCODE 0.2 +55.2 55214 2.5 JUND RARA PKNOX1 NR2F6 KDM1A FOS 5MWI_A-194 HSALNG0140688 CNGA2 MAGEA4
GH0XJ151750 Enhancer 0.5 ENCODE 0.4 +15.4 15415 0.7 ZNF654 REST CTCF RAD21 SMC3 MYNN piR-61145 CNGA2 MAGEA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CNGA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CNGA2

Top Transcription factor binding sites by QIAGEN in the CNGA2 gene promoter:
  • AREB6
  • C/EBPalpha
  • CBF(2)
  • CBF-A
  • CHOP-10
  • HFH-1
  • NF-YB
  • Pax-3
  • USF-1
  • USF1

Genomic Locations for CNGA2 Gene

Latest Assembly
chrX:151,734,746-151,745,564
(GRCh38/hg38)
Size:
10,819 bases
Orientation:
Plus strand

Previous Assembly
chrX:150,903,218-150,914,036
(GRCh37/hg19 by Entrez Gene)
Size:
10,819 bases
Orientation:
Plus strand

chrX:150,906,923-150,913,776
(GRCh37/hg19 by Ensembl)
Size:
6,854 bases
Orientation:
Plus strand

Genomic View for CNGA2 Gene

Genes around CNGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNGA2 Gene

Proteins for CNGA2 Gene

  • Protein details for CNGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16280-CNGA2_HUMAN
    Recommended name:
    Cyclic nucleotide-gated olfactory channel
    Protein Accession:
    Q16280
    Secondary Accessions:
    • A0AVD0

    Protein attributes for CNGA2 Gene

    Size:
    664 amino acids
    Molecular mass:
    76048 Da
    Quaternary structure:
    • Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).

neXtProt entry for CNGA2 Gene

Post-translational modifications for CNGA2 Gene

  • Glycosylation at Asn379
  • Modification sites at PhosphoSitePlus

Other Protein References for CNGA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNGA2 Gene

Domains & Families for CNGA2 Gene

Gene Families for CNGA2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Voltage-gated ion channels

Protein Domains for CNGA2 Gene

InterPro:
Blocks:
  • Cyclic nucleotide-binding domain

Suggested Antigen Peptide Sequences for CNGA2 Gene

GenScript: Design optimal peptide antigens:
  • Cyclic nucleotide-gated channel alpha-2 (CNGA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16280

UniProtKB/Swiss-Prot:

CNGA2_HUMAN :
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
Domain:
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
Family:
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
genes like me logo Genes that share domains with CNGA2: view

Function for CNGA2 Gene

Molecular function for CNGA2 Gene

UniProtKB/Swiss-Prot Function:
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Phenotypes From GWAS Catalog for CNGA2 Gene

Gene Ontology (GO) - Molecular Function for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005216 ion channel activity IEA --
GO:0005222 intracellular cAMP-activated cation channel activity IBA 21873635
GO:0005223 intracellular cGMP-activated cation channel activity IBA 21873635
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CNGA2: view
genes like me logo Genes that share phenotypes with CNGA2: view

Animal Models for CNGA2 Gene

MGI Knock Outs for CNGA2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNGA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNGA2 Gene

Localization for CNGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNGA2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNGA2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane TAS --
GO:0060170 ciliary membrane TAS --
genes like me logo Genes that share ontologies with CNGA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CNGA2 Gene

Pathways & Interactions for CNGA2 Gene

genes like me logo Genes that share pathways with CNGA2: view

Gene Ontology (GO) - Biological Process for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007608 sensory perception of smell IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0050896 response to stimulus IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with CNGA2: view

No data available for SIGNOR curated interactions for CNGA2 Gene

Drugs & Compounds for CNGA2 Gene

(2) Drugs for CNGA2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CNGA2: view

Transcripts for CNGA2 Gene

mRNA/cDNA for CNGA2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CNGA2

Alternative Splicing Database (ASD) splice patterns (SP) for CNGA2 Gene

No ASD Table

Relevant External Links for CNGA2 Gene

GeneLoc Exon Structure for
CNGA2

Expression for CNGA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNGA2 Gene

mRNA differential expression in normal tissues according to GTEx for CNGA2 Gene

This gene is overexpressed in Testis (x46.3).

Protein differential expression in normal tissues from HIPED for CNGA2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNGA2 Gene



Protein tissue co-expression partners for CNGA2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CNGA2

SOURCE GeneReport for Unigene cluster for CNGA2 Gene:

Hs.447360

Evidence on tissue expression from TISSUES for CNGA2 Gene

  • Lung(2.8)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CNGA2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cranial nerve
  • head
  • nose
  • olfactory bulb
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with CNGA2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CNGA2 Gene

Orthologs for CNGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNGA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CNGA2 29 30
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CNGA2 29 30
  • 90.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CNGA2 29 30
  • 89.85 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CNGA2 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cnga2 29 16 30
  • 88.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cnga2 29
  • 87.56 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CNGA2 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CNGA2 29 30
  • 74.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CNGA2 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cnga2 29
  • 67.58 (n)
Zebrafish
(Danio rerio)
Actinopterygii cnga5 29 30
  • 66.25 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Cng 30
  • 37 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tax-4 30
  • 39 (a)
ManyToMany
cng-1 30
  • 31 (a)
ManyToMany
che-6 30
  • 30 (a)
ManyToMany
cng-2 30
  • 23 (a)
ManyToMany
cng-3 30
  • 22 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 57 (a)
OneToMany
Species where no ortholog for CNGA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CNGA2 Gene

ENSEMBL:
Gene Tree for CNGA2 (if available)
TreeFam:
Gene Tree for CNGA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNGA2: view image
Alliance of Genome Resources:
Additional Orthologs for CNGA2

Paralogs for CNGA2 Gene

(4) SIMAP similar genes for CNGA2 Gene using alignment to 1 proteins:

  • CNGA2_HUMAN
genes like me logo Genes that share paralogs with CNGA2: view

Variants for CNGA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CNGA2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs1057519072 Uncertain Significance: not provided 151,743,137(+) C/T
NM_005140.1(CNGA2):c.634C>T (p.Arg212Ter)
NONSENSE
rs113295831 Benign: not provided 151,744,030(+) G/A
NM_005140.1(CNGA2):c.1527G>A (p.Gln509=)
SYNONYMOUS
rs1192417524 Likely Benign: not provided 151,743,943(+) C/T
NM_005140.1(CNGA2):c.1440C>T (p.Tyr480=)
SYNONYMOUS
rs142562634 Benign: not provided 151,738,527(+) A/C
NM_005140.1(CNGA2):c.44A>C (p.Asn15Thr)
MISSENSE
rs144366408 Benign: not provided 151,739,696(+) G/T
NM_005140.1(CNGA2):c.338G>T (p.Gly113Val)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CNGA2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CNGA2 Gene

Variant ID Type Subtype PubMed ID
nsv518142 CNV gain 19592680

Variation tolerance for CNGA2 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNGA2 Gene

Human Gene Mutation Database (HGMD)
CNGA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNGA2
Leiden Open Variation Database (LOVD)
CNGA2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNGA2 Gene

Disorders for CNGA2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CNGA2 Gene - From: ORP and COP

- elite association - COSMIC cancer census association via MalaCards
Search CNGA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CNGA2

genes like me logo Genes that share disorders with CNGA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNGA2 Gene

Publications for CNGA2 Gene

  1. Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. (PMID: 7532814) Distler M … Hofmann F (Neuropharmacology 1994) 2 3 4
  2. The first mutation in CNGA2 in two brothers with anosmia. (PMID: 25156905) Karstensen HG … Tommerup N (Clinical genetics 2015) 3 72
  3. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F … Kaupp UB (Pharmacological reviews 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues. (PMID: 14618336) Cheng KT … Yao X (Histochemistry and cell biology 2003) 3 22

Products for CNGA2 Gene

Sources for CNGA2 Gene