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Aliases for CNBD1 Gene

Aliases for CNBD1 Gene

  • Cyclic Nucleotide Binding Domain Containing 1 2 3 5
  • Cyclic Nucleotide-Binding Domain-Containing Protein 1 3

External Ids for CNBD1 Gene

Previous GeneCards Identifiers for CNBD1 Gene

  • GC08P087948
  • GC08P083088

Summaries for CNBD1 Gene

GeneCards Summary for CNBD1 Gene

CNBD1 (Cyclic Nucleotide Binding Domain Containing 1) is a Protein Coding gene.

Additional gene information for CNBD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNBD1 Gene

Genomics for CNBD1 Gene

GeneHancer (GH) Regulatory Elements for CNBD1 Gene

Promoters and enhancers for CNBD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J086822 Promoter 0.5 EPDnew 650.3 -44.0 -43977 0.1 CNBD1 PIR44040
GH08J086782 Enhancer 0.2 FANTOM5 10.1 -83.9 -83850 0.3 CNGB3 CNBD1 ENSG00000253568 ENSG00000253778 PIR44040
GH08J086871 Enhancer 0.7 ENCODE 0.7 +4.8 4806 0.2 ELF3 CTCF PKNOX1 SIN3A RAD21 ETS1 GATA3 ZNF143 SMC3 ZNF444 CNBD1 PIR32878
GH08J087055 Enhancer 0.6 ENCODE 0.1 +189.1 189086 0.2 ZNF687 SUZ12 GATAD2B DPF2 MTA3 CTBP1 GATA3 TARDBP RCOR1 ZNF444 PIR32878 PIR55008 CNBD1
GH08J087013 Enhancer 0.4 ENCODE 0.1 +146.8 146816 1.1 NANOG POU5F1 CEBPG PIR32878 CNBD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNBD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNBD1 gene promoter:

Genomic Locations for CNBD1 Gene

Genomic Locations for CNBD1 Gene
chr8:86,866,442-87,615,219
(GRCh38/hg38)
Size:
748,778 bases
Orientation:
Plus strand
chr8:87,878,670-88,627,447
(GRCh37/hg19)

Genomic View for CNBD1 Gene

Genes around CNBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNBD1 Gene

Proteins for CNBD1 Gene

  • Protein details for CNBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA66-CNBD1_HUMAN
    Recommended name:
    Cyclic nucleotide-binding domain-containing protein 1
    Protein Accession:
    Q8NA66

    Protein attributes for CNBD1 Gene

    Size:
    436 amino acids
    Molecular mass:
    50224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNBD1 Gene

Post-translational modifications for CNBD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNBD1 Gene

No data available for DME Specific Peptides for CNBD1 Gene

Domains & Families for CNBD1 Gene

Gene Families for CNBD1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CNBD1 Gene

Suggested Antigen Peptide Sequences for CNBD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CNBD1: view

No data available for UniProtKB/Swiss-Prot for CNBD1 Gene

Function for CNBD1 Gene

Phenotypes From GWAS Catalog for CNBD1 Gene

Phenotypes for CNBD1 Gene

genes like me logo Genes that share phenotypes with CNBD1: view

Animal Models for CNBD1 Gene

MGI Knock Outs for CNBD1:
  • Cnbd1 Cnbd1<tm1b(EUCOMM)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for CNBD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CNBD1 Gene

Localization for CNBD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNBD1 gene
Compartment Confidence
mitochondrion 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CNBD1 Gene

Pathways & Interactions for CNBD1 Gene

SuperPathways for CNBD1 Gene

No Data Available

Interacting Proteins for CNBD1 Gene

Gene Ontology (GO) - Biological Process for CNBD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNBD1 Gene

Drugs & Compounds for CNBD1 Gene

No Compound Related Data Available

Transcripts for CNBD1 Gene

mRNA/cDNA for CNBD1 Gene

(7) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNBD1 Gene

Cyclic nucleotide binding domain containing 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for CNBD1

Alternative Splicing Database (ASD) splice patterns (SP) for CNBD1 Gene

No ASD Table

Relevant External Links for CNBD1 Gene

GeneLoc Exon Structure for
CNBD1
ECgene alternative splicing isoforms for
CNBD1

Expression for CNBD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNBD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNBD1 Gene

This gene is overexpressed in Testis (x51.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNBD1 Gene



Protein tissue co-expression partners for CNBD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNBD1 Gene:

CNBD1

SOURCE GeneReport for Unigene cluster for CNBD1 Gene:

Hs.246284
genes like me logo Genes that share expression patterns with CNBD1: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNBD1 Gene

Orthologs for CNBD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNBD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNBD1 34 33
  • 99.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CNBD1 34 33
  • 83.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CNBD1 33
  • 81.52 (n)
rat
(Rattus norvegicus)
Mammalia Cnbd1 33
  • 71.19 (n)
mouse
(Mus musculus)
Mammalia Cnbd1 16 34 33
  • 70.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CNBD1 34
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNBD1 34
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100535758 33
  • 49.14 (n)
CNBD1 34
  • 26 (a)
OneToOne
Species where no ortholog for CNBD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNBD1 Gene

ENSEMBL:
Gene Tree for CNBD1 (if available)
TreeFam:
Gene Tree for CNBD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CNBD1: view image

Paralogs for CNBD1 Gene

No data available for Paralogs for CNBD1 Gene

Variants for CNBD1 Gene

Sequence variations from dbSNP and Humsavar for CNBD1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000001794 -- 87,424,726(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000003860 -- 87,062,102(+) T/G intron_variant
rs1000010859 -- 87,397,942(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000013601 -- 87,292,010(+) G/T intron_variant
rs1000016547 -- 86,955,402(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CNBD1 Gene

Variant ID Type Subtype PubMed ID
dgv1408e214 CNV loss 21293372
dgv2102e212 CNV loss 25503493
esv1125411 CNV insertion 17803354
esv1731753 CNV insertion 17803354
esv2422239 CNV duplication 17116639
esv2661135 CNV deletion 23128226
esv2669887 CNV deletion 23128226
esv2673295 CNV deletion 23128226
esv2737269 CNV deletion 23290073
esv2764068 CNV loss 21179565
esv3412046 CNV insertion 20981092
esv3543794 CNV deletion 23714750
esv3572888 CNV loss 25503493
esv3572891 CNV loss 25503493
esv3572892 CNV loss 25503493
esv3572893 CNV loss 25503493
esv3617918 CNV gain 21293372
esv3617921 CNV gain 21293372
esv3617922 CNV loss 21293372
esv3617923 CNV loss 21293372
esv3617924 CNV loss 21293372
esv3617925 CNV loss 21293372
esv3891433 CNV loss 25118596
esv3891434 CNV loss 25118596
esv3891435 CNV loss 25118596
esv3891436 CNV gain 25118596
nsv1026222 CNV loss 25217958
nsv1032266 CNV gain 25217958
nsv1075154 CNV deletion 25765185
nsv1076095 CNV deletion 25765185
nsv1115114 CNV deletion 24896259
nsv1122197 CNV deletion 24896259
nsv1124358 CNV deletion 24896259
nsv1143370 CNV deletion 24896259
nsv398035 CNV deletion 16902084
nsv465734 CNV gain 19166990
nsv525991 CNV loss 19592680
nsv611709 CNV gain 21841781
nsv611711 CNV loss 21841781
nsv831383 CNV gain 17160897
nsv956089 CNV deletion 24416366

Variation tolerance for CNBD1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNBD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNBD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNBD1 Gene

Disorders for CNBD1 Gene

Additional Disease Information for CNBD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CNBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNBD1 Gene

Publications for CNBD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. [The influence of calcineurin gene polymorphism on morphofunctional characteristics of cardiovascular system of athletes]. (PMID: 18825932) Akhmetov II … Rogozkin VA (Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 2008) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 58
  5. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PMID: 17463248) Scott LJ … Boehnke M (Science (New York, N.Y.) 2007) 44 58

Products for CNBD1 Gene

  • Addgene plasmids for CNBD1

Sources for CNBD1 Gene

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