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Aliases for CMTR2 Gene

Aliases for CMTR2 Gene

  • Cap Methyltransferase 2 2 3 4 5
  • FtsJ Methyltransferase Domain-Containing Protein 1 3 4
  • FtsJ Methyltransferase Domain Containing 1 2 3
  • Cap2 2O-Ribose Methyltransferase 2 3 4
  • Protein Adrift Homolog 3 4
  • FTSJD1 3 4
  • HMTr2 3 4
  • MTr2 3 4
  • AFT 3 4
  • Cap-Specific MRNA (Nucleoside-2-O-)-Methyltransferase 2 3
  • Adrift Homolog (Drosophila) 2
  • Adrift Homolog 3
  • EC 2.1.1.296 4

External Ids for CMTR2 Gene

Previous HGNC Symbols for CMTR2 Gene

  • FTSJD1

Summaries for CMTR2 Gene

GeneCards Summary for CMTR2 Gene

CMTR2 (Cap Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and mRNA (nucleoside-2-O-)-methyltransferase activity. An important paralog of this gene is CMTR1.

UniProtKB/Swiss-Prot for CMTR2 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

Additional gene information for CMTR2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTR2 Gene

Genomics for CMTR2 Gene

GeneHancer (GH) Regulatory Elements for CMTR2 Gene

Promoters and enhancers for CMTR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I071287 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.3 +0.6 592 2.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 CMTR2 LOC102723786 SF3B3 ZNF19 IST1 FUK HYDIN ZNF23 AP1G1 DHX38
GH16I071893 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 9.8 -605.9 -605933 3.8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC IST1 PIR45337 ZNF821 PIR43283 PHLPP2 HYDIN ENSG00000247324 ZNF19 MARVELD3 DHX38
GH16I070522 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +765.6 765648 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 SF3B3 COG4 PDXDC2P-NPIPB14P PDXDC2P NFAT5 NONOP1 DDX19B PDPR DDX19A ZNF23
GH16I071459 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 -171.6 -171609 3.1 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF23 ENSG00000247324 DHX38 IST1 AP1G1 SF3B3 COG4 ATXN1L CMTR2 PHLPP2
GH16I072092 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 -804.1 -804142 3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DHX38 TXNL4B ATXN1L IST1 AP1G1 DHODH CMTR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CMTR2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CMTR2 Gene

Genomic Locations for CMTR2 Gene
chr16:71,281,389-71,289,715
(GRCh38/hg38)
Size:
8,327 bases
Orientation:
Minus strand
chr16:71,315,292-71,323,618
(GRCh37/hg19)

Genomic View for CMTR2 Gene

Genes around CMTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTR2 Gene

Proteins for CMTR2 Gene

  • Protein details for CMTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYT2-CMTR2_HUMAN
    Recommended name:
    Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 2
    Protein Accession:
    Q8IYT2
    Secondary Accessions:
    • B2RCD5
    • D3DWS1
    • Q8NE77
    • Q8NFR5
    • Q9H8Z4
    • Q9NUS3
    • Q9NXF5

    Protein attributes for CMTR2 Gene

    Size:
    770 amino acids
    Molecular mass:
    88120 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM49718.1; Type=Frameshift; Positions=337; Evidence={ECO:0000305}; Sequence=BAA91058.1; Type=Frameshift; Positions=739; Evidence={ECO:0000305}; Sequence=BAB14452.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CMTR2 Gene

Post-translational modifications for CMTR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTR2 Gene

Domains & Families for CMTR2 Gene

Gene Families for CMTR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CMTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CMTR2: view

No data available for UniProtKB/Swiss-Prot for CMTR2 Gene

Function for CMTR2 Gene

Molecular function for CMTR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(2-O-methyl-ribonucleotide)-[mRNA].
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

Enzyme Numbers (IUBMB) for CMTR2 Gene

Phenotypes From GWAS Catalog for CMTR2 Gene

Gene Ontology (GO) - Molecular Function for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004483 mRNA (nucleoside-2-O-)-methyltransferase activity IDA 21310715
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CMTR2: view
genes like me logo Genes that share phenotypes with CMTR2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTR2 Gene

Localization for CMTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTR2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTR2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21310715
GO:0005737 cytoplasm IDA,IEA 21310715
genes like me logo Genes that share ontologies with CMTR2: view

Pathways & Interactions for CMTR2 Gene

genes like me logo Genes that share pathways with CMTR2: view

Pathways by source for CMTR2 Gene

1 BioSystems pathway for CMTR2 Gene

Interacting Proteins for CMTR2 Gene

Gene Ontology (GO) - Biological Process for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006370 7-methylguanosine mRNA capping IDA,IEA 21310715
GO:0006397 mRNA processing IEA --
GO:0032259 methylation IEA --
GO:0097310 cap2 mRNA methylation IDA 21310715
genes like me logo Genes that share ontologies with CMTR2: view

No data available for SIGNOR curated interactions for CMTR2 Gene

Drugs & Compounds for CMTR2 Gene

No Compound Related Data Available

Transcripts for CMTR2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTR2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: - -
SP9:

Relevant External Links for CMTR2 Gene

GeneLoc Exon Structure for
CMTR2
ECgene alternative splicing isoforms for
CMTR2

Expression for CMTR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTR2 Gene

Protein differential expression in normal tissues from HIPED for CMTR2 Gene

This gene is overexpressed in Tlymphocyte (39.5), Lymph node (12.3), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CMTR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CMTR2 Gene:

CMTR2

Evidence on tissue expression from TISSUES for CMTR2 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with CMTR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTR2 Gene

Orthologs for CMTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTSJD1 33
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia CMTR2 33 34
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia CMTR2 33 34
  • 88.66 (n)
rat
(Rattus norvegicus)
Mammalia Cmtr2 33
  • 80.05 (n)
mouse
(Mus musculus)
Mammalia Cmtr2 33 16 34
  • 79.62 (n)
oppossum
(Monodelphis domestica)
Mammalia CMTR2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTR2 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJD1 33
  • 71.32 (n)
CMTR2 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTR2 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsjd1 33
  • 58.92 (n)
zebrafish
(Danio rerio)
Actinopterygii cmtr2 33 34
  • 52.69 (n)
Dr.11574 33
fruit fly
(Drosophila melanogaster)
Insecta aft 34
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y40D12A.1 34
  • 20 (a)
OneToOne
Species where no ortholog for CMTR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CMTR2 Gene

ENSEMBL:
Gene Tree for CMTR2 (if available)
TreeFam:
Gene Tree for CMTR2 (if available)

Paralogs for CMTR2 Gene

Paralogs for CMTR2 Gene

genes like me logo Genes that share paralogs with CMTR2: view

Variants for CMTR2 Gene

Sequence variations from dbSNP and Humsavar for CMTR2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000633521 -- 71,282,206(-) TAACTA/TA downstream_transcript_variant
rs1001058701 -- 71,281,882(-) A/G downstream_transcript_variant
rs1001198519 -- 71,287,814(-) C/A intron_variant
rs1001495842 -- 71,288,443(-) C/T intron_variant
rs1001692041 -- 71,287,564(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CMTR2 Gene

Variant ID Type Subtype PubMed ID
esv2758653 CNV gain 17122850
esv988018 OTHER inversion 20482838
nsv1861 CNV insertion 18451855
nsv509631 CNV insertion 20534489
nsv511050 OTHER complex 20534489
nsv7285 OTHER inversion 18451855

Variation tolerance for CMTR2 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTR2 Gene

Disorders for CMTR2 Gene

Additional Disease Information for CMTR2

No disorders were found for CMTR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTR2 Gene

Publications for CMTR2 Gene

  1. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. (PMID: 21310715) Werner M … Bujnicki JM (Nucleic acids research 2011) 2 3 4 58
  2. Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. (PMID: 24402442) Smietanski M … Bujnicki JM (Nature communications 2014) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for CMTR2 Gene

Sources for CMTR2 Gene

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