Aliases for CMTR1 Gene
External Ids for CMTR1 Gene
Previous HGNC Symbols for CMTR1 Gene
Previous GeneCards Identifiers for CMTR1 Gene
GeneCards Summary for CMTR1 Gene
CMTR1 (Cap Methyltransferase 1) is a Protein Coding gene. Diseases associated with CMTR1 include Murray Valley Encephalitis and Vaccinia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA (nucleoside-2'-O-)-methyltransferase activity. An important paralog of this gene is CMTR2.
UniProtKB/Swiss-Prot Summary for CMTR1 Gene
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.