Aliases for CMTR1 Gene

Aliases for CMTR1 Gene

  • Cap Methyltransferase 1 2 3 4 5
  • KIAA0082 2 3 4
  • ISG95 2 3 4
  • MTr1 2 3 4
  • Cap-Specific MRNA (Nucleoside-2'-O-)-Methyltransferase 1 3 4
  • FtsJ Methyltransferase Domain-Containing Protein 2 3 4
  • FtsJ Methyltransferase Domain Containing 2 2 3
  • Interferon-Stimulated Gene 95 KDa Protein 3 4
  • Cap1 2'O-Ribose Methyltransferase 1 3 4
  • FTSJD2 3 4
  • HMTr1 3 4
  • S-Adenosyl-L-Methionine-Dependent Methyltransferase FTSJD2 3
  • EC 2.1.1.57 4
  • CMTR1 5
  • MTR1 4

External Ids for CMTR1 Gene

Previous HGNC Symbols for CMTR1 Gene

  • KIAA0082
  • FTSJD2

Previous GeneCards Identifiers for CMTR1 Gene

  • GC06P037401
  • GC06P037506
  • GC06P037465
  • GC06P037864
  • GC06P042842
  • GC06P043191
  • GC06P043381
  • GC06P046070
  • GC06P037870
  • GC06P038432
  • GC06P039023
  • GC06P039610
  • GC06P040171
  • GC06P041255
  • GC06P041928
  • GC06P042571

Summaries for CMTR1 Gene

GeneCards Summary for CMTR1 Gene

CMTR1 (Cap Methyltransferase 1) is a Protein Coding gene. Diseases associated with CMTR1 include Murray Valley Encephalitis and Vaccinia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA (nucleoside-2'-O-)-methyltransferase activity. An important paralog of this gene is CMTR2.

UniProtKB/Swiss-Prot Summary for CMTR1 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

Additional gene information for CMTR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CMTR1 Gene

Genomics for CMTR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CMTR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J037432 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 613.7 +0.3 287 2.6 BRCA1 SP1 CREB1 GATAD2A ATF7 ZNF629 PRDM10 REST SIX5 POLR2A CMTR1 HSALNG0049814 LOC107986531 LINC02520 FGD2 SRSF3 RNF8 TMEM217
GH06J037423 Promoter/Enhancer 1.2 EPDnew ENCODE 600.4 -9.3 -9324 0.3 CREB1 HNRNPL PRDM10 ZHX2 FOXA1 PRDM1 PKNOX1 KAT8 ZNF501 HDAC1 RF00017-5504 piR-57845-014 CMTR1 SRSF3 RNF8
GH06J036675 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 63 -752.4 -752365 10.4 ZNF221 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 PRDM10 ZNF629 TFE3 CDKN1A SRSF3 CMTR1 STK38 RNF8 ENSG00000237719 BRPF3 MAPK14 RNU1-88P C6orf89
GH06J036592 Promoter/Enhancer 3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 51.3 -835.8 -835795 10.7 ZNF221 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 RFX1 SRSF3 C6orf89 CMTR1 KCTD20 STK38 BRPF3 CDKN1A RAB44 FKBP5 ETV7
GH06J036884 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 56.8 -545.9 -545873 4.9 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 C6orf89 CMTR1 SRSF3 PPIL1 BRPF3 FGD2 TBC1D22B CDKN1A RAB44 MTCH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CMTR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CMTR1

Genomic Locations for CMTR1 Gene

Genomic Locations for CMTR1 Gene
chr6:37,433,214-37,482,844
(GRCh38/hg38)
Size:
49,631 bases
Orientation:
Plus strand
chr6:37,400,907-37,450,603
(GRCh37/hg19)
Size:
49,697 bases
Orientation:
Plus strand

Genomic View for CMTR1 Gene

Genes around CMTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTR1 Gene

Proteins for CMTR1 Gene

  • Protein details for CMTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G2-CMTR1_HUMAN
    Recommended name:
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Protein Accession:
    Q8N1G2
    Secondary Accessions:
    • A8K949
    • Q14670
    • Q96FJ9

    Protein attributes for CMTR1 Gene

    Size:
    835 amino acids
    Molecular mass:
    95321 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus).
    SequenceCaution:
    • Sequence=BAA07893.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CMTR1 Gene

neXtProt entry for CMTR1 Gene

Post-translational modifications for CMTR1 Gene

  • Ubiquitination at Lys487, Lys608, Lys777, and Lys823
  • Modification sites at PhosphoSitePlus

Other Protein References for CMTR1 Gene

No data available for DME Specific Peptides for CMTR1 Gene

Domains & Families for CMTR1 Gene

Gene Families for CMTR1 Gene

Protein Domains for CMTR1 Gene

Suggested Antigen Peptide Sequences for CMTR1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-stimulated gene 95 kDa protein (MTR1_HUMAN)
  • FtsJ methyltransferase domain containing 2 (Q5T7F8_HUMAN)
  • FtsJ methyltransferase domain containing 2 (Q5T7F9_HUMAN)
genes like me logo Genes that share domains with CMTR1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CMTR1 Gene

Function for CMTR1 Gene

Molecular function for CMTR1 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60864, Rhea:RHEA-COMP:15683, Rhea:RHEA-COMP:15685, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:143975, ChEBI:CHEBI:143977; EC=2.1.1.57; Evidence={ECO:0000269|PubMed:21310715};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60860, Rhea:RHEA-COMP:15682, Rhea:RHEA-COMP:15684, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:143974, ChEBI:CHEBI:143976; EC=2.1.1.57; Evidence={ECO:0000269|PubMed:21310715};.
UniProtKB/Swiss-Prot Induction:
By interferons alpha and beta, and by Vaccinia virus infection.

Enzyme Numbers (IUBMB) for CMTR1 Gene

Phenotypes From GWAS Catalog for CMTR1 Gene

Gene Ontology (GO) - Molecular Function for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity IEA,IDA 20713356
GO:0005515 protein binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CMTR1: view
genes like me logo Genes that share phenotypes with CMTR1: view

Animal Model Products

CRISPR Products

miRNA for CMTR1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CMTR1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTR1 Gene

Localization for CMTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTR1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21310715
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CMTR1: view

Pathways & Interactions for CMTR1 Gene

PathCards logo

SuperPathways for CMTR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006370 7-methylguanosine mRNA capping IEA,IMP 20713356
GO:0006397 mRNA processing IEA --
GO:0032259 methylation IEA --
GO:0080009 mRNA methylation IEA,IDA 20713356
GO:0097309 cap1 mRNA methylation IDA 21310715
genes like me logo Genes that share ontologies with CMTR1: view

No data available for Pathways by source and SIGNOR curated interactions for CMTR1 Gene

Drugs & Compounds for CMTR1 Gene

(2) Drugs for CMTR1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ademetionine Approved, Investigational Nutra Target 0
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for CMTR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with CMTR1: view

Transcripts for CMTR1 Gene

mRNA/cDNA for CMTR1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CMTR1

Alternative Splicing Database (ASD) splice patterns (SP) for CMTR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

ExUns: 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27
SP1: - -
SP2:
SP3:
SP4: - -
SP5:
SP6: - - -
SP7:
SP8:
SP9:

Relevant External Links for CMTR1 Gene

GeneLoc Exon Structure for
CMTR1

Expression for CMTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CMTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMTR1 Gene

This gene is overexpressed in Testis (20.6), Breast (13.9), and Lymph node (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CMTR1 Gene



Protein tissue co-expression partners for CMTR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CMTR1

Evidence on tissue expression from TISSUES for CMTR1 Gene

  • Nervous system(4.8)
  • Eye(4.7)
  • Lung(4.3)
  • Liver(4.3)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with CMTR1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTR1 Gene

Orthologs for CMTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMTR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FTSJD2 30 31
  • 99.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CMTR1 31
  • 97 (a)
OneToOne
FTSJD2 30
  • 92.38 (n)
Cow
(Bos Taurus)
Mammalia FTSJD2 31
  • 95 (a)
OneToOne
CMTR1 30
  • 91.26 (n)
Mouse
(Mus musculus)
Mammalia Cmtr1 30 17 31
  • 87.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cmtr1 30
  • 86.66 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CMTR1 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CMTR1 31
  • 84 (a)
OneToOne
FTSJD2 30
  • 76.72 (n)
Lizard
(Anolis carolinensis)
Reptilia CMTR1 31
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7896 30
Zebrafish
(Danio rerio)
Actinopterygii cmtr1 30 31
  • 67.44 (n)
OneToOne
zgc55336 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000826 30
  • 52.41 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6379 30 31
  • 50 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.13 30
  • 51.75 (n)
Y53F4B.13 31
  • 31 (a)
OneToOne
Species where no ortholog for CMTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CMTR1 Gene

ENSEMBL:
Gene Tree for CMTR1 (if available)
TreeFam:
Gene Tree for CMTR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CMTR1: view image

Paralogs for CMTR1 Gene

Paralogs for CMTR1 Gene

(1) SIMAP similar genes for CMTR1 Gene using alignment to 4 proteins:

  • CMTR1_HUMAN
  • H0Y4T0_HUMAN
  • H0YCQ1_HUMAN
  • Q5T7F5_HUMAN
genes like me logo Genes that share paralogs with CMTR1: view

Variants for CMTR1 Gene

Additional dbSNP identifiers (rs#s) for CMTR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CMTR1 Gene

Variant ID Type Subtype PubMed ID
esv2752124 CNV gain 17911159
nsv1015689 CNV gain 25217958

Variation tolerance for CMTR1 Gene

Residual Variation Intolerance Score: 4.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CMTR1 Gene

Disorders for CMTR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CMTR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
murray valley encephalitis
  • australian encephalitis
vaccinia
- elite association - COSMIC cancer census association via MalaCards
Search CMTR1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CMTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMTR1 Gene

Publications for CMTR1 Gene

  1. Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. (PMID: 20713356) Bélanger F … Pelletier J (The Journal of biological chemistry 2010) 2 3 4
  2. Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. (PMID: 24402442) Smietanski M … Bujnicki JM (Nature communications 2014) 3 4
  3. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. (PMID: 21310715) Werner M … Bujnicki JM (Nucleic acids research 2011) 3 4
  4. The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity. (PMID: 18533109) Haline-Vaz T … Zanchin NI (Biochemical and biophysical research communications 2008) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for CMTR1 Gene

Sources for CMTR1 Gene