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Aliases for CMTM8 Gene

Aliases for CMTM8 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 8 2 3 5
  • Chemokine-Like Factor Superfamily Member 8 3 4
  • CKLFSF8 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 8 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 8 2
  • Chemokine-Like Factor Super Family 8 2
  • Chemokine-Like Factor Superfamily 8 2
  • CKLFSF8-V2 3

External Ids for CMTM8 Gene

Previous HGNC Symbols for CMTM8 Gene


Previous GeneCards Identifiers for CMTM8 Gene

  • GC03P032256
  • GC03P032217
  • GC03P032280

Summaries for CMTM8 Gene

Entrez Gene Summary for CMTM8 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for CMTM8 Gene

CMTM8 (CKLF Like MARVEL Transmembrane Domain Containing 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is PLLP.

Additional gene information for CMTM8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM8 Gene

Genomics for CMTM8 Gene

GeneHancer (GH) Regulatory Elements for CMTM8 Gene

Promoters and enhancers for CMTM8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J032237 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 527 2.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GLIS2 ZNF143 NFKBIZ CMTM8 GC03M032236 ENSG00000261572 ENSG00000270377 GC03M031988
GH03J032177 Enhancer 1.1 Ensembl ENCODE 11.6 -61.0 -60973 1.2 PKNOX1 MLX ARID4B SIN3A ZNF143 ZFP91 RUNX3 RXRA REST KAT8 RPSAP11 CMTM8 KRT18P15 RPL31P18 CMTM6 OSBPL10 ENSG00000236732 GC03M031988
GH03J032215 Enhancer 1 ENCODE 12.7 -22.3 -22274 1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 NFKBIZ CMTM8 KRT18P15 ENSG00000261572 GC03P032191 GC03M031988
GH03J032302 Enhancer 1 Ensembl ENCODE dbSUPER 11.5 +64.8 64772 2.8 SOX13 GATAD2A FOXA2 FOXA3 HMG20A FOXA1 YY1 SKI ZNF217 CTBP1 CMTM8 KRT18P15 GC03P032261 CMTM7 GC03M031988
GH03J032288 Enhancer 0.6 ENCODE dbSUPER 16.2 +50.5 50475 1.4 GABPB1 ZFP36 CMTM8 KRT18P15 GC03P032261 CMTM7 GC03M031988
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CMTM8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CMTM8 gene promoter:
  • Arnt
  • E2F-1
  • E2F
  • MIF-1
  • Evi-1
  • AP-2gamma
  • Cart-1
  • Max1
  • c-Myc
  • Pax-4a

Genomic Locations for CMTM8 Gene

Genomic Locations for CMTM8 Gene
131,647 bases
Plus strand
131,647 bases
Plus strand

Genomic View for CMTM8 Gene

Genes around CMTM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM8 Gene

Proteins for CMTM8 Gene

  • Protein details for CMTM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A5D6I7
    • Q8IW01

    Protein attributes for CMTM8 Gene

    173 amino acids
    Molecular mass:
    19572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM8 Gene


neXtProt entry for CMTM8 Gene

Post-translational modifications for CMTM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM8 Gene

No data available for DME Specific Peptides for CMTM8 Gene

Domains & Families for CMTM8 Gene

Gene Families for CMTM8 Gene

Protein Domains for CMTM8 Gene


Suggested Antigen Peptide Sequences for CMTM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chemokine-like factor family.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM8: view

Function for CMTM8 Gene

Phenotypes From GWAS Catalog for CMTM8 Gene

Gene Ontology (GO) - Molecular Function for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 16263120
GO:0019911 structural constituent of myelin sheath IBA --
genes like me logo Genes that share ontologies with CMTM8: view
genes like me logo Genes that share phenotypes with CMTM8: view

Animal Model Products

miRNA for CMTM8 Gene

miRTarBase miRNAs that target CMTM8

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM8 Gene

Localization for CMTM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM8 Gene

Isoform 1: Membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM8 gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CMTM8: view

Pathways & Interactions for CMTM8 Gene

SuperPathways for CMTM8 Gene

No Data Available

Interacting Proteins for CMTM8 Gene

Gene Ontology (GO) - Biological Process for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001766 membrane raft polarization IBA --
GO:0006935 chemotaxis IEA --
GO:0008104 protein localization IBA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0042552 myelination IBA --
genes like me logo Genes that share ontologies with CMTM8: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM8 Gene

Drugs & Compounds for CMTM8 Gene

(1) Drugs for CMTM8 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 387
genes like me logo Genes that share compounds with CMTM8: view

Transcripts for CMTM8 Gene

mRNA/cDNA for CMTM8 Gene

Unigene Clusters for CMTM8 Gene

CKLF-like MARVEL transmembrane domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM8 Gene

No ASD Table

Relevant External Links for CMTM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMTM8 Gene

This gene is overexpressed in Liver (x5.6) and Pancreas (x5.3).

Protein differential expression in normal tissues from HIPED for CMTM8 Gene

This gene is overexpressed in Spleen (51.4) and Islet of Langerhans (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CMTM8 Gene

Protein tissue co-expression partners for CMTM8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMTM8 Gene:


SOURCE GeneReport for Unigene cluster for CMTM8 Gene:


mRNA Expression by UniProt/SwissProt for CMTM8 Gene:

Tissue specificity: Highly expressed in liver and pancreas.

Evidence on tissue expression from TISSUES for CMTM8 Gene

  • Liver(4.2)
  • Blood(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CMTM8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTM8 Gene

Orthologs for CMTM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CMTM8 34 33
  • 99.81 (n)
(Canis familiaris)
Mammalia CMTM8 34 33
  • 94.03 (n)
(Bos Taurus)
Mammalia CMTM8 34 33
  • 91.91 (n)
(Rattus norvegicus)
Mammalia Cmtm8 33
  • 87.28 (n)
(Mus musculus)
Mammalia Cmtm8 16 34 33
  • 86.71 (n)
(Ornithorhynchus anatinus)
Mammalia CMTM8 34
  • 77 (a)
(Monodelphis domestica)
Mammalia CMTM8 34
  • 46 (a)
(Gallus gallus)
Aves CMTM8 34 33
  • 79 (n)
(Anolis carolinensis)
Reptilia CMTM8 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm8 33
  • 67.26 (n)
Str.18775 33
(Danio rerio)
Actinopterygii zgc:158657 33
  • 61.01 (n)
CMTM8 34
  • 47 (a)
Species where no ortholog for CMTM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM8 Gene

Gene Tree for CMTM8 (if available)
Gene Tree for CMTM8 (if available)
Evolutionary constrained regions (ECRs) for CMTM8: view image

Paralogs for CMTM8 Gene

Paralogs for CMTM8 Gene

(3) SIMAP similar genes for CMTM8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CMTM8: view

Variants for CMTM8 Gene

Sequence variations from dbSNP and Humsavar for CMTM8 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000017882 -- 32,293,985(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000026099 -- 32,352,631(+) G/A intron_variant
rs1000069770 -- 32,312,242(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000099266 -- 32,325,391(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000102847 -- 32,365,635(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM8 Gene

Variant ID Type Subtype PubMed ID
esv23045 CNV loss 19812545
esv2511457 CNV deletion 19546169
esv2676585 CNV deletion 23128226
esv3307004 CNV mobile element insertion 20981092
esv3365412 CNV insertion 20981092
esv3385139 CNV insertion 20981092
esv3561699 CNV deletion 23714750
esv3595770 CNV loss 21293372
nsv1003285 CNV gain 25217958
nsv1011573 CNV gain 25217958
nsv1131691 CNV deletion 24896259
nsv236546 CNV deletion 16902084
nsv474894 CNV novel sequence insertion 20440878
nsv526741 CNV loss 19592680
nsv590046 CNV loss 21841781
nsv979815 CNV duplication 23825009

Variation tolerance for CMTM8 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM8 Gene

Disorders for CMTM8 Gene

Additional Disease Information for CMTM8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CMTM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM8 Gene

Publications for CMTM8 Gene

  1. An alternative splice form of CMTM8 induces apoptosis. (PMID: 17681841) Li D … Wang Y (The international journal of biochemistry & cell biology 2007) 3 4 22 58
  2. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W … Ma D (Genomics 2003) 3 4 22 58
  3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 44 58
  4. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y … Zhang H (Genetic epidemiology 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CMTM8 Gene

Sources for CMTM8 Gene

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