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This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
CMTM6 (CKLF Like MARVEL Transmembrane Domain Containing 6) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 28813410 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005768 | endosome | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
GO:0016021 | integral component of membrane | IBA | 21873635 |
GO:0031901 | early endosome membrane | IEA,IDA | 28813417 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015031 | protein transport | IMP | 28813417 |
GO:0031647 | regulation of protein stability | IMP | 28813410 |
GO:0032456 | endocytic recycling | IMP | 28813417 |
GO:0043312 | neutrophil degranulation | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CMTM6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CMTM6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cmtm6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cmtm6 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CMTM6 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CMTM6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CMTM6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CMTM6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CMTM6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cmtm6 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cmtm6 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2454 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35574803 | - | p.Thr91Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3595776 | CNV | loss | 21293372 |
nsv1003285 | CNV | gain | 25217958 |
nsv834652 | CNV | loss | 17160897 |
No disorders were found for CMTM6 Gene.